A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth
As is well known, plant products have been increasingly utilized in the pharmaceutical industry in recent years. By combining conventional techniques and modern methodology, the future of phytomedicines appears promising. <i>Pogostemon Cablin</i> (patchouli) is an important herb used fre...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/28/8/3469 |
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| author | Sehrish Fatima Iqra Farzeen Asma Ashraf Bilal Aslam Muhammad Umar Ijaz Sumreen Hayat Muhammad Hassan Sarfraz Saima Zafar Nimrah Zafar Jeremiah Oshiomame Unuofin Sogolo Lucky Lebelo Saima Muzammil |
| author_facet | Sehrish Fatima Iqra Farzeen Asma Ashraf Bilal Aslam Muhammad Umar Ijaz Sumreen Hayat Muhammad Hassan Sarfraz Saima Zafar Nimrah Zafar Jeremiah Oshiomame Unuofin Sogolo Lucky Lebelo Saima Muzammil |
| author_sort | Sehrish Fatima |
| collection | DOAJ |
| description | As is well known, plant products have been increasingly utilized in the pharmaceutical industry in recent years. By combining conventional techniques and modern methodology, the future of phytomedicines appears promising. <i>Pogostemon Cablin</i> (patchouli) is an important herb used frequently in the fragrance industries and has various therapeutic benefits. Traditional medicine has long used the essential oil of patchouli (<i>P. cablin</i>) as a flavoring agent recognized by the FDA. This is a gold mine for battling pathogens in China and India. In recent years, this plant has seen a significant surge in use, and approximately 90% of the world’s patchouli oil is produced by Indonesia. In traditional therapies, it is used for the treatment of colds, fever, vomiting, headaches, and stomachaches. Patchouli oil is used in curing many diseases and in aromatherapy to treat depression and stress, soothe nerves, regulate appetite, and enhance sexual attraction. More than 140 substances, including alcohols, terpenoids, flavonoids, organic acids, phytosterols, lignins, aldehydes, alkaloids, and glycosides, have been identified in <i>P. cablin</i>. Pachypodol (C18H16O7) is an important bioactive compound found in <i>P. cablin.</i> Pachypodol (C18H16O7) and many other biologically essential chemicals have been separated from the leaves of <i>P. cablin</i> and many other medicinally significant plants using repeated column chromatography on silica gel. Pachypodol’s bioactive potential has been shown by a variety of assays and methodologies. It has been found to have a number of biological activities, including anti-inflammatory, antioxidant, anti-mutagenic, antimicrobial, antidepressant, anticancer, antiemetic, antiviral, and cytotoxic ones. The current study, which is based on the currently available scientific literature, intends to close the knowledge gap regarding the pharmacological effects of patchouli essential oil and pachypodol, a key bioactive molecule found in this plant. |
| first_indexed | 2024-03-11T04:41:13Z |
| format | Article |
| id | doaj.art-233f8f9ed3c545ea92da25cc8eaf846b |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T04:41:13Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-233f8f9ed3c545ea92da25cc8eaf846b2023-11-17T20:39:25ZengMDPI AGMolecules1420-30492023-04-01288346910.3390/molecules28083469A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin BenthSehrish Fatima0Iqra Farzeen1Asma Ashraf2Bilal Aslam3Muhammad Umar Ijaz4Sumreen Hayat5Muhammad Hassan Sarfraz6Saima Zafar7Nimrah Zafar8Jeremiah Oshiomame Unuofin9Sogolo Lucky Lebelo10Saima Muzammil11Department of Zoology, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Government College University, Faisalabad 38000, PakistanInstitute of Microbiology, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Wildlife and Fisheries, University of Agriculture, Faisalabad 38040, PakistanInstitute of Microbiology, Government College University, Faisalabad 38000, PakistanInstitute of Microbiology, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Government College University, Faisalabad 38000, PakistanDepartment of Zoology, Government College University, Faisalabad 38000, PakistanDepartment of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Private Bag X06, Florida 1710, South AfricaDepartment of Life and Consumer Sciences, College of Agriculture and Environmental Sciences, Private Bag X06, Florida 1710, South AfricaInstitute of Microbiology, Government College University, Faisalabad 38000, PakistanAs is well known, plant products have been increasingly utilized in the pharmaceutical industry in recent years. By combining conventional techniques and modern methodology, the future of phytomedicines appears promising. <i>Pogostemon Cablin</i> (patchouli) is an important herb used frequently in the fragrance industries and has various therapeutic benefits. Traditional medicine has long used the essential oil of patchouli (<i>P. cablin</i>) as a flavoring agent recognized by the FDA. This is a gold mine for battling pathogens in China and India. In recent years, this plant has seen a significant surge in use, and approximately 90% of the world’s patchouli oil is produced by Indonesia. In traditional therapies, it is used for the treatment of colds, fever, vomiting, headaches, and stomachaches. Patchouli oil is used in curing many diseases and in aromatherapy to treat depression and stress, soothe nerves, regulate appetite, and enhance sexual attraction. More than 140 substances, including alcohols, terpenoids, flavonoids, organic acids, phytosterols, lignins, aldehydes, alkaloids, and glycosides, have been identified in <i>P. cablin</i>. Pachypodol (C18H16O7) is an important bioactive compound found in <i>P. cablin.</i> Pachypodol (C18H16O7) and many other biologically essential chemicals have been separated from the leaves of <i>P. cablin</i> and many other medicinally significant plants using repeated column chromatography on silica gel. Pachypodol’s bioactive potential has been shown by a variety of assays and methodologies. It has been found to have a number of biological activities, including anti-inflammatory, antioxidant, anti-mutagenic, antimicrobial, antidepressant, anticancer, antiemetic, antiviral, and cytotoxic ones. The current study, which is based on the currently available scientific literature, intends to close the knowledge gap regarding the pharmacological effects of patchouli essential oil and pachypodol, a key bioactive molecule found in this plant.https://www.mdpi.com/1420-3049/28/8/3469<i>Pogostemon cablin</i>anti-microbialanti-cancerousanti-inflammatoryflavonoidsessential oil |
| spellingShingle | Sehrish Fatima Iqra Farzeen Asma Ashraf Bilal Aslam Muhammad Umar Ijaz Sumreen Hayat Muhammad Hassan Sarfraz Saima Zafar Nimrah Zafar Jeremiah Oshiomame Unuofin Sogolo Lucky Lebelo Saima Muzammil A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth Molecules <i>Pogostemon cablin</i> anti-microbial anti-cancerous anti-inflammatory flavonoids essential oil |
| title | A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth |
| title_full | A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth |
| title_fullStr | A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth |
| title_full_unstemmed | A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth |
| title_short | A Comprehensive Review on Pharmacological Activities of Pachypodol: A Bioactive Compound of an Aromatic Medicinal Plant Pogostemon Cablin Benth |
| title_sort | comprehensive review on pharmacological activities of pachypodol a bioactive compound of an aromatic medicinal plant pogostemon cablin benth |
| topic | <i>Pogostemon cablin</i> anti-microbial anti-cancerous anti-inflammatory flavonoids essential oil |
| url | https://www.mdpi.com/1420-3049/28/8/3469 |
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