Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.
Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the ao...
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC3583902?pdf=render |
| _version_ | 1798043609924108288 |
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| author | Hiroki Tanaka Nobuhiro Zaima Takeshi Sasaki Takahiro Hayasaka Naoko Goto-Inoue Kenji Onoue Koji Ikegami Yoshifumi Morita Naoto Yamamoto Yuuki Mano Masaki Sano Takaaki Saito Kohji Sato Hiroyuki Konno Mitsutoshi Setou Naoki Unno |
| author_facet | Hiroki Tanaka Nobuhiro Zaima Takeshi Sasaki Takahiro Hayasaka Naoko Goto-Inoue Kenji Onoue Koji Ikegami Yoshifumi Morita Naoto Yamamoto Yuuki Mano Masaki Sano Takaaki Saito Kohji Sato Hiroyuki Konno Mitsutoshi Setou Naoki Unno |
| author_sort | Hiroki Tanaka |
| collection | DOAJ |
| description | Abdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease. |
| first_indexed | 2024-04-11T22:51:30Z |
| format | Article |
| id | doaj.art-2340a9c9c9454d6f89a993f190bc7251 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-11T22:51:30Z |
| publishDate | 2013-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-2340a9c9c9454d6f89a993f190bc72512022-12-22T03:58:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0182e5739810.1371/journal.pone.0057398Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm.Hiroki TanakaNobuhiro ZaimaTakeshi SasakiTakahiro HayasakaNaoko Goto-InoueKenji OnoueKoji IkegamiYoshifumi MoritaNaoto YamamotoYuuki ManoMasaki SanoTakaaki SaitoKohji SatoHiroyuki KonnoMitsutoshi SetouNaoki UnnoAbdominal aortic aneurysm (AAA) is a common disease among elderly individuals. However, the precise pathophysiology of AAA remains unknown. In AAA, an intraluminal thrombus prevents luminal perfusion of oxygen, allowing only the adventitial vaso vasorum (VV) to deliver oxygen and nutrients to the aortic wall. In this study, we examined changes in the adventitial VV wall in AAA to clarify the histopathological mechanisms underlying AAA. We found marked intimal hyperplasia of the adventitial VV in the AAA sac; further, immunohistological studies revealed proliferation of smooth muscle cells, which caused luminal stenosis of the VV. We also found decreased HemeB signals in the aortic wall of the sac as compared with those in the aortic wall of the neck region in AAA. The stenosis of adventitial VV in the AAA sac and the malperfusion of the aortic wall observed in the present study are new aspects of AAA pathology that are expected to enhance our understanding of this disease.http://europepmc.org/articles/PMC3583902?pdf=render |
| spellingShingle | Hiroki Tanaka Nobuhiro Zaima Takeshi Sasaki Takahiro Hayasaka Naoko Goto-Inoue Kenji Onoue Koji Ikegami Yoshifumi Morita Naoto Yamamoto Yuuki Mano Masaki Sano Takaaki Saito Kohji Sato Hiroyuki Konno Mitsutoshi Setou Naoki Unno Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. PLoS ONE |
| title | Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. |
| title_full | Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. |
| title_fullStr | Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. |
| title_full_unstemmed | Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. |
| title_short | Adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm. |
| title_sort | adventitial vasa vasorum arteriosclerosis in abdominal aortic aneurysm |
| url | http://europepmc.org/articles/PMC3583902?pdf=render |
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