Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study
BackgroundWhereas the Montreal Cognitive Assessment (MoCA) and Addenbrooke’s cognitive examination-revised (ACE-R) are commonly used tests for the detection of post-stroke cognitive impairment (PSCI), these instruments take 10–30 min to administer and do not assess processing speed, which is a criti...
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1195220/full |
| _version_ | 1797778291979976704 |
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| author | Xiaoxiao Zhao Xiaoxiao Zhao Shujuan Dai Shujuan Dai Rong Zhang Xinjie Chen Mingjie Zhao Mingjie Zhao Michael F. Bergeron Xianbo Zhou Xianbo Zhou Junyan Zhang Junyan Zhang Lianmei Zhong Lianmei Zhong J. Wesson Ashford J. Wesson Ashford Xiaolei Liu Xiaolei Liu |
| author_facet | Xiaoxiao Zhao Xiaoxiao Zhao Shujuan Dai Shujuan Dai Rong Zhang Xinjie Chen Mingjie Zhao Mingjie Zhao Michael F. Bergeron Xianbo Zhou Xianbo Zhou Junyan Zhang Junyan Zhang Lianmei Zhong Lianmei Zhong J. Wesson Ashford J. Wesson Ashford Xiaolei Liu Xiaolei Liu |
| author_sort | Xiaoxiao Zhao |
| collection | DOAJ |
| description | BackgroundWhereas the Montreal Cognitive Assessment (MoCA) and Addenbrooke’s cognitive examination-revised (ACE-R) are commonly used tests for the detection of post-stroke cognitive impairment (PSCI), these instruments take 10–30 min to administer and do not assess processing speed, which is a critical impairment in PSCI. MemTrax (MTx) is a continuous recognition test, which evaluates complex information processing, accuracy, speed, and attention, in 2 min.AimTo evaluate whether MTx is an effective and practical tool for PSCI assessment.MethodsThis study enrolled acute ischemic stroke (AIS) patients who have assessed the cognitive status including MTx, clinical dementia rating (CDR), MoCA, Neuropsychiatric Inventory (NPI), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), the National Institute of Health Stroke Scale (NIHSS), modified Rankin scale (mRS), and Barthel Index of activity of daily living (BI) combined with the physical examinations of the neurologic system at the 90-day (D90) after the AIS. The primary endpoint of this study was establishing MTx cut-offs for distinguishing PSCI from AIS.ResultsOf the 104 participants, 60 were classified to the PSCI group. The optimized cut-off value of MTx-%C (percent correct) was 78%, with a sensitivity and specificity for detecting PSCI from Non-PSCI of 90.0 and 84.1%, respectively, and an AUC of 0.919. Regarding the MTx-Cp (Composite score = MTx-%C/MTx-RT), using 46.3 as a cut-off value, the sensitivity and specificity for detecting PSCI from Non-PSCI were 80.0 and 93.2%, with an AUC of 0.925. Multivariate linear regression showed that PSCI reduced the MTx-%C (Coef. −14.18, 95% CI −18.41∼−9.95, p < 0.001) and prolonged the MTx-RT (response time) (Coef. 0.29, 95% CI 0.16∼0.43, p < 0.001) and reduced the MTx-CP (Coef. −19.11, 95% CI −24.29∼−13.93, p < 0.001).ConclusionMemTrax (MTx) is valid and effective for screening for PSCI among target patients and is a potentially valuable and practical tool in the clinical follow-up, monitoring, and case management of PSCI. |
| first_indexed | 2024-03-12T23:15:10Z |
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| language | English |
| last_indexed | 2024-03-12T23:15:10Z |
| publishDate | 2023-07-01 |
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| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-234685981f8f4235ae1711d46bebd8c42023-07-17T09:45:24ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612023-07-011710.3389/fnhum.2023.11952201195220Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional studyXiaoxiao Zhao0Xiaoxiao Zhao1Shujuan Dai2Shujuan Dai3Rong Zhang4Xinjie Chen5Mingjie Zhao6Mingjie Zhao7Michael F. Bergeron8Xianbo Zhou9Xianbo Zhou10Junyan Zhang11Junyan Zhang12Lianmei Zhong13Lianmei Zhong14J. Wesson Ashford15J. Wesson Ashford16Xiaolei Liu17Xiaolei Liu18Department of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Province Clinical Research Center for Neurological Disease, Kunming, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Province Clinical Research Center for Neurological Disease, Kunming, ChinaDepartment of Neurology, Kunming Second People’s Hospital, Kunming, Yunnan, ChinaDepartment of Neurology, The First Affiliated Hospital of Dali University, Dali, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Province Clinical Research Center for Neurological Disease, Kunming, ChinaDepartment of Health Sciences, University of Hartford, West Hartford, CT, United StatesZhongze Therapeutics, Shanghai, ChinaCenter for Alzheimer’s Research, Washington Institute of Clinical Research, Vienna, VA, United StatesDepartment of Clinical Epidemiology and Evidence-based Medicine, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan, ChinaBothwin Clinical Study Consultant, Shanghai, ChinaDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Province Clinical Research Center for Neurological Disease, Kunming, China0War Related Illness and Injury Study Center, VA Palo Alto Health Care System (HCS), Palo Alto, CA, United States1Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, United StatesDepartment of Neurology, The First Affiliated Hospital of Kunming Medical University, Kunming, ChinaYunnan Province Clinical Research Center for Neurological Disease, Kunming, ChinaBackgroundWhereas the Montreal Cognitive Assessment (MoCA) and Addenbrooke’s cognitive examination-revised (ACE-R) are commonly used tests for the detection of post-stroke cognitive impairment (PSCI), these instruments take 10–30 min to administer and do not assess processing speed, which is a critical impairment in PSCI. MemTrax (MTx) is a continuous recognition test, which evaluates complex information processing, accuracy, speed, and attention, in 2 min.AimTo evaluate whether MTx is an effective and practical tool for PSCI assessment.MethodsThis study enrolled acute ischemic stroke (AIS) patients who have assessed the cognitive status including MTx, clinical dementia rating (CDR), MoCA, Neuropsychiatric Inventory (NPI), Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), the National Institute of Health Stroke Scale (NIHSS), modified Rankin scale (mRS), and Barthel Index of activity of daily living (BI) combined with the physical examinations of the neurologic system at the 90-day (D90) after the AIS. The primary endpoint of this study was establishing MTx cut-offs for distinguishing PSCI from AIS.ResultsOf the 104 participants, 60 were classified to the PSCI group. The optimized cut-off value of MTx-%C (percent correct) was 78%, with a sensitivity and specificity for detecting PSCI from Non-PSCI of 90.0 and 84.1%, respectively, and an AUC of 0.919. Regarding the MTx-Cp (Composite score = MTx-%C/MTx-RT), using 46.3 as a cut-off value, the sensitivity and specificity for detecting PSCI from Non-PSCI were 80.0 and 93.2%, with an AUC of 0.925. Multivariate linear regression showed that PSCI reduced the MTx-%C (Coef. −14.18, 95% CI −18.41∼−9.95, p < 0.001) and prolonged the MTx-RT (response time) (Coef. 0.29, 95% CI 0.16∼0.43, p < 0.001) and reduced the MTx-CP (Coef. −19.11, 95% CI −24.29∼−13.93, p < 0.001).ConclusionMemTrax (MTx) is valid and effective for screening for PSCI among target patients and is a potentially valuable and practical tool in the clinical follow-up, monitoring, and case management of PSCI.https://www.frontiersin.org/articles/10.3389/fnhum.2023.1195220/fullstrokecognitive impairmentanalysescross-sectionalexecutive functionassessment |
| spellingShingle | Xiaoxiao Zhao Xiaoxiao Zhao Shujuan Dai Shujuan Dai Rong Zhang Xinjie Chen Mingjie Zhao Mingjie Zhao Michael F. Bergeron Xianbo Zhou Xianbo Zhou Junyan Zhang Junyan Zhang Lianmei Zhong Lianmei Zhong J. Wesson Ashford J. Wesson Ashford Xiaolei Liu Xiaolei Liu Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study Frontiers in Human Neuroscience stroke cognitive impairment analyses cross-sectional executive function assessment |
| title | Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study |
| title_full | Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study |
| title_fullStr | Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study |
| title_full_unstemmed | Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study |
| title_short | Using MemTrax memory test to screen for post-stroke cognitive impairment after ischemic stroke: a cross-sectional study |
| title_sort | using memtrax memory test to screen for post stroke cognitive impairment after ischemic stroke a cross sectional study |
| topic | stroke cognitive impairment analyses cross-sectional executive function assessment |
| url | https://www.frontiersin.org/articles/10.3389/fnhum.2023.1195220/full |
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