Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study
Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed mic...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Associação Neurologia Cognitiva e do Comportamento
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| Series: | Dementia & Neuropsychologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352&lng=en&tlng=en |
| _version_ | 1818151003061485568 |
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| author | Leonel Tadao Takada Paulo Camiz Lea T. Grinberg Claudia da Costa Leite |
| author_facet | Leonel Tadao Takada Paulo Camiz Lea T. Grinberg Claudia da Costa Leite |
| author_sort | Leonel Tadao Takada |
| collection | DOAJ |
| description | Abstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation. |
| first_indexed | 2024-12-11T13:31:54Z |
| format | Article |
| id | doaj.art-23489490627446a1a74a189513c656b7 |
| institution | Directory Open Access Journal |
| issn | 1980-5764 |
| language | English |
| last_indexed | 2024-12-11T13:31:54Z |
| publisher | Associação Neurologia Cognitiva e do Comportamento |
| record_format | Article |
| series | Dementia & Neuropsychologia |
| spelling | doaj.art-23489490627446a1a74a189513c656b72022-12-22T01:05:14ZengAssociação Neurologia Cognitiva e do ComportamentoDementia & Neuropsychologia1980-57643435235710.1590/S1980-57642009DN30400015S1980-57642009000400352Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case studyLeonel Tadao TakadaPaulo CamizLea T. GrinbergClaudia da Costa LeiteAbstract A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-b peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352&lng=en&tlng=endementiacerebral amyloid angiopathyvascular dementia. |
| spellingShingle | Leonel Tadao Takada Paulo Camiz Lea T. Grinberg Claudia da Costa Leite Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study Dementia & Neuropsychologia dementia cerebral amyloid angiopathy vascular dementia. |
| title | Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
| title_full | Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
| title_fullStr | Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
| title_full_unstemmed | Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
| title_short | Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study |
| title_sort | non inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia a case study |
| topic | dementia cerebral amyloid angiopathy vascular dementia. |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1980-57642009000400352&lng=en&tlng=en |
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