Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism
This study intends to explore the antihyperglycemic effect and the possible hypoglycemic mechanism of garlic (Allium sativum L.) polysaccharide (GP) using an animal model. Kunming mice were fed with GP (1.25, 2.5, 5.0 g/kg‧bw) for five weeks after insulin resistance (IR) engendering by a high-oil-hi...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | NFS Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352364623000068 |
| _version_ | 1797803912583970816 |
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| author | Chanyuan Xie Wei Gao Xue Li Shuangshuang Luo Di Wu Fook Yee Chye |
| author_facet | Chanyuan Xie Wei Gao Xue Li Shuangshuang Luo Di Wu Fook Yee Chye |
| author_sort | Chanyuan Xie |
| collection | DOAJ |
| description | This study intends to explore the antihyperglycemic effect and the possible hypoglycemic mechanism of garlic (Allium sativum L.) polysaccharide (GP) using an animal model. Kunming mice were fed with GP (1.25, 2.5, 5.0 g/kg‧bw) for five weeks after insulin resistance (IR) engendering by a high-oil-high-sugar diet and streptozotocin (STZ). Intragastric administration of GP effectively improved the disease of polyphagia and polydipsia in diabetic mice. The fasting blood glucose (FBG) in the high-dose GP (DGH) group was meaningfully 42% lower than that in the diabetic model (DC) group showing its hypoglycemic effect. GP might manipulate hepatic glycogen metabolism by regulating the content of glucokinase (GK), glycogen synthase (GS), and phosphoenolpyruvate carboxykinase (PEPCK). Results showed that GP with a low relative molecular weight (MW) of 2.0 kDa consisted predominately of a 2,1-β-D-Fruf backbone with 20.7% side chains owning the structure-effect on hypoglycemia indicating it could be a potential supplement for the intervention and management of hyperglycemia. |
| first_indexed | 2024-03-13T05:28:10Z |
| format | Article |
| id | doaj.art-234896eca0f741488769a45df1503b6b |
| institution | Directory Open Access Journal |
| issn | 2352-3646 |
| language | English |
| last_indexed | 2024-03-13T05:28:10Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NFS Journal |
| spelling | doaj.art-234896eca0f741488769a45df1503b6b2023-06-15T04:56:24ZengElsevierNFS Journal2352-36462023-06-01311927Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolismChanyuan Xie0Wei Gao1Xue Li2Shuangshuang Luo3Di Wu4Fook Yee Chye5Food Quality and Safety Research Group, Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia; School of Life Sciences and Food Engineering, Hebei University of Engineering, 056038 Handan, Hebei, PR China; Key Laboratory of Natural Products and Functional Food Development in Handan City, School of Life Sciences and Food Engineering, Hebei University of Engineering, 056038 Handan, Hebei, PR ChinaKey Laboratory of Comprehensive Utilization of Plant Resources in Hebei Province, Chenguang Biotech Group CO., LTD, 057250 Handan, Hebei, PR China; Chenguang Biotech Group CO., LTD, 057250 Handan, Hebei, PR China; Corresponding author at: Key Laboratory of Comprehensive Utilization of Plant Resources in Hebei Province, Chenguang Biotech Group CO., LTD, 057250 Handan, Hebei, PR China.Chenguang Biotech Group CO., LTD, 057250 Handan, Hebei, PR ChinaChenguang Biotech Group CO., LTD, 057250 Handan, Hebei, PR ChinaChenguang Biotech Group CO., LTD, 057250 Handan, Hebei, PR ChinaFood Quality and Safety Research Group, Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia; Corresponding author at: Food Quality and Safety Research Group, Faculty of Food Science and Nutrition, Universiti Malaysia Sabah, 88400 Kota Kinabalu, Sabah, Malaysia.This study intends to explore the antihyperglycemic effect and the possible hypoglycemic mechanism of garlic (Allium sativum L.) polysaccharide (GP) using an animal model. Kunming mice were fed with GP (1.25, 2.5, 5.0 g/kg‧bw) for five weeks after insulin resistance (IR) engendering by a high-oil-high-sugar diet and streptozotocin (STZ). Intragastric administration of GP effectively improved the disease of polyphagia and polydipsia in diabetic mice. The fasting blood glucose (FBG) in the high-dose GP (DGH) group was meaningfully 42% lower than that in the diabetic model (DC) group showing its hypoglycemic effect. GP might manipulate hepatic glycogen metabolism by regulating the content of glucokinase (GK), glycogen synthase (GS), and phosphoenolpyruvate carboxykinase (PEPCK). Results showed that GP with a low relative molecular weight (MW) of 2.0 kDa consisted predominately of a 2,1-β-D-Fruf backbone with 20.7% side chains owning the structure-effect on hypoglycemia indicating it could be a potential supplement for the intervention and management of hyperglycemia.http://www.sciencedirect.com/science/article/pii/S2352364623000068Garlic polysaccharideStructural characterizationGlucose metabolismType 2 diabetesHypoglycemic |
| spellingShingle | Chanyuan Xie Wei Gao Xue Li Shuangshuang Luo Di Wu Fook Yee Chye Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism NFS Journal Garlic polysaccharide Structural characterization Glucose metabolism Type 2 diabetes Hypoglycemic |
| title | Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism |
| title_full | Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism |
| title_fullStr | Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism |
| title_full_unstemmed | Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism |
| title_short | Garlic (Allium sativum L.) polysaccharide ameliorates type 2 diabetes mellitus (T2DM) via the regulation of hepatic glycogen metabolism |
| title_sort | garlic allium sativum l polysaccharide ameliorates type 2 diabetes mellitus t2dm via the regulation of hepatic glycogen metabolism |
| topic | Garlic polysaccharide Structural characterization Glucose metabolism Type 2 diabetes Hypoglycemic |
| url | http://www.sciencedirect.com/science/article/pii/S2352364623000068 |
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