Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship?
Introduction: The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin´s lymphoma followed i...
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2015-09-01
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| Series: | Acta Médica Portuguesa |
| Subjects: | |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207 |
| _version_ | 1811242346744905728 |
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| author | Mónica Jerónimo Sónia Silva Manuela Benedito Manuel João Brito |
| author_facet | Mónica Jerónimo Sónia Silva Manuela Benedito Manuel João Brito |
| author_sort | Mónica Jerónimo |
| collection | DOAJ |
| description |
Introduction: The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin´s lymphoma followed in a Pediatric Oncology Unit.
Material and Methods: By reviewing Hodgkin’s lymphomas data from the past 16 years (collected prospectively), an apparently large incidence of autoimmune diseases, mostly in female patients, was noted. We decided to do this retrospective study with an update on follow-up. Data analyzed: age, gender, autoimmune disease, temporal relation with lymphoma, lymphoma´s stage, histologic subtype and treatment.
Results: Fifty-two cases were included, 7 (13.5%) of which, all female, had an autoimmune disease diagnosed previously, simultaneously or after lymphoma. Autoimmune diseases were: juvenile idiopathic arthritis, inflammatory bowel disease, Behçet´s disease, autoimmune hepatitis, systemic erythematosus lupus, Hashimoto´s thyroiditis and idiopathic thrombocytopenic purpura. The diagnosis was made after lymphoma in 4 patients, before in 2 and simultaneously in 1 patient. All cases, except the one with simultaneous diagnosis, are out of treatment and without oncologic disease relapse. No deaths were registered.
Discussion: There was an important prevalence of autoimmune diseases in girls with Hodgkin´s lymphoma. We present data and discuss the possible causes based on a literature review.
Conclusions: This relationship should be invoked, requiring more studies, especially in pediatric age.
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| first_indexed | 2024-04-12T13:50:07Z |
| format | Article |
| id | doaj.art-234a176c225e47f8a56d9edb8ea327fd |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-12T13:50:07Z |
| publishDate | 2015-09-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-234a176c225e47f8a56d9edb8ea327fd2022-12-22T03:30:33ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582015-09-0128610.20344/amp.6207Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship?Mónica Jerónimo0Sónia Silva1Manuela Benedito2Manuel João Brito3Serviço de Oncologia Pediátrica. Hospital Pediátrico de Coimbra. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Oncologia Pediátrica. Hospital Pediátrico de Coimbra. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Hematologia. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal.Serviço de Oncologia Pediátrica. Hospital Pediátrico de Coimbra. Centro Hospitalar e Universitário de Coimbra. Coimbra. Portugal. Introduction: The relationship between lymphomas and autoimmune diseases has been reported as bi-directional, however there is a few data in pediatric population. The aim of this work is to evaluate the prevalence of autoimmune diseases in children and adolescents with Hodgkin´s lymphoma followed in a Pediatric Oncology Unit. Material and Methods: By reviewing Hodgkin’s lymphomas data from the past 16 years (collected prospectively), an apparently large incidence of autoimmune diseases, mostly in female patients, was noted. We decided to do this retrospective study with an update on follow-up. Data analyzed: age, gender, autoimmune disease, temporal relation with lymphoma, lymphoma´s stage, histologic subtype and treatment. Results: Fifty-two cases were included, 7 (13.5%) of which, all female, had an autoimmune disease diagnosed previously, simultaneously or after lymphoma. Autoimmune diseases were: juvenile idiopathic arthritis, inflammatory bowel disease, Behçet´s disease, autoimmune hepatitis, systemic erythematosus lupus, Hashimoto´s thyroiditis and idiopathic thrombocytopenic purpura. The diagnosis was made after lymphoma in 4 patients, before in 2 and simultaneously in 1 patient. All cases, except the one with simultaneous diagnosis, are out of treatment and without oncologic disease relapse. No deaths were registered. Discussion: There was an important prevalence of autoimmune diseases in girls with Hodgkin´s lymphoma. We present data and discuss the possible causes based on a literature review. Conclusions: This relationship should be invoked, requiring more studies, especially in pediatric age. https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207Autoimmune DiseasesChildHodgkin Disease. |
| spellingShingle | Mónica Jerónimo Sónia Silva Manuela Benedito Manuel João Brito Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? Acta Médica Portuguesa Autoimmune Diseases Child Hodgkin Disease. |
| title | Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
| title_full | Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
| title_fullStr | Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
| title_full_unstemmed | Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
| title_short | Hodgkin´s Lymphoma and Autoimmunity: Is There a Relationship? |
| title_sort | hodgkin´s lymphoma and autoimmunity is there a relationship |
| topic | Autoimmune Diseases Child Hodgkin Disease. |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/6207 |
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