Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases
The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a critical player in gut homeostasis maintenance as it ensures the complex crosstalk between gut microbes (both commensals and pathogens) and the host immune system. Highly specialized epithelial cells co...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-01-01
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| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/10/2/289 |
| _version_ | 1827656739024011264 |
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| author | Carmine Stolfi Claudia Maresca Giovanni Monteleone Federica Laudisi |
| author_facet | Carmine Stolfi Claudia Maresca Giovanni Monteleone Federica Laudisi |
| author_sort | Carmine Stolfi |
| collection | DOAJ |
| description | The intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a critical player in gut homeostasis maintenance as it ensures the complex crosstalk between gut microbes (both commensals and pathogens) and the host immune system. Highly specialized epithelial cells constantly cope with several protective and harmful agents to maintain the multiple physiological functions of the barrier as well as its integrity. However, both genetic defects and environmental factors can break such equilibrium, thus promoting gut dysbiosis, dysregulated immune-inflammatory responses, and even the development of chronic pathological conditions. Here, we review and discuss the molecular and cellular pathways underlying intestinal barrier structural and functional homeostasis, focusing on potential alterations that may undermine this fine balance. |
| first_indexed | 2024-03-09T22:32:35Z |
| format | Article |
| id | doaj.art-234d654718404493a9b2888892cf0082 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-09T22:32:35Z |
| publishDate | 2022-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-234d654718404493a9b2888892cf00822023-11-23T18:53:18ZengMDPI AGBiomedicines2227-90592022-01-0110228910.3390/biomedicines10020289Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and DiseasesCarmine Stolfi0Claudia Maresca1Giovanni Monteleone2Federica Laudisi3Department of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyDepartment of Systems Medicine, University of Rome “Tor Vergata”, 00133 Rome, ItalyThe intestinal mucosal barrier, also referred to as intestinal barrier, is widely recognized as a critical player in gut homeostasis maintenance as it ensures the complex crosstalk between gut microbes (both commensals and pathogens) and the host immune system. Highly specialized epithelial cells constantly cope with several protective and harmful agents to maintain the multiple physiological functions of the barrier as well as its integrity. However, both genetic defects and environmental factors can break such equilibrium, thus promoting gut dysbiosis, dysregulated immune-inflammatory responses, and even the development of chronic pathological conditions. Here, we review and discuss the molecular and cellular pathways underlying intestinal barrier structural and functional homeostasis, focusing on potential alterations that may undermine this fine balance.https://www.mdpi.com/2227-9059/10/2/289intestinal epithelial cellsmucosal barriermicrobiotainflammatory bowel diseasesdietmucus layer |
| spellingShingle | Carmine Stolfi Claudia Maresca Giovanni Monteleone Federica Laudisi Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases Biomedicines intestinal epithelial cells mucosal barrier microbiota inflammatory bowel diseases diet mucus layer |
| title | Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases |
| title_full | Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases |
| title_fullStr | Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases |
| title_full_unstemmed | Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases |
| title_short | Implication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases |
| title_sort | implication of intestinal barrier dysfunction in gut dysbiosis and diseases |
| topic | intestinal epithelial cells mucosal barrier microbiota inflammatory bowel diseases diet mucus layer |
| url | https://www.mdpi.com/2227-9059/10/2/289 |
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