Biomaterials are the key to unlock spheroid function and therapeutic potential
Spheroids are three-dimensional cell aggregates that mimic fundamental aspects of the native tissue microenvironment better than single cells, making them a promising platform for the study of tissue development and therapeutics. Spheroids have been investigated for decades as models in cancer resea...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-09-01
|
| Series: | Biomaterials and Biosystems |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666534423000090 |
| _version_ | 1827856065721532416 |
|---|---|
| author | David H. Ramos-Rodriguez J. Kent Leach |
| author_facet | David H. Ramos-Rodriguez J. Kent Leach |
| author_sort | David H. Ramos-Rodriguez |
| collection | DOAJ |
| description | Spheroids are three-dimensional cell aggregates that mimic fundamental aspects of the native tissue microenvironment better than single cells, making them a promising platform for the study of tissue development and therapeutics. Spheroids have been investigated for decades as models in cancer research, yet we have only just scratched the surface of their potential clinical utility in cell-based therapies. Like many cells, spheroids commonly exhibit a loss of key attributes upon implantation, motivating the need for strategies to regulate their function in situ. Biomaterials offer numerous opportunities to preserve spheroid function and guide spheroid behavior by tailoring the local microenvironment. |
| first_indexed | 2024-03-12T12:19:25Z |
| format | Article |
| id | doaj.art-234e883c034846269668bbb7b934c981 |
| institution | Directory Open Access Journal |
| issn | 2666-5344 |
| language | English |
| last_indexed | 2024-03-12T12:19:25Z |
| publishDate | 2023-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomaterials and Biosystems |
| spelling | doaj.art-234e883c034846269668bbb7b934c9812023-08-30T05:54:55ZengElsevierBiomaterials and Biosystems2666-53442023-09-0111100080Biomaterials are the key to unlock spheroid function and therapeutic potentialDavid H. Ramos-Rodriguez0J. Kent Leach1Department of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USADepartment of Orthopaedic Surgery, UC Davis Health, Sacramento, CA 95817, USA; Department of Biomedical Engineering, University of California, Davis, Davis, CA 95616, USA; Corresponding author.Spheroids are three-dimensional cell aggregates that mimic fundamental aspects of the native tissue microenvironment better than single cells, making them a promising platform for the study of tissue development and therapeutics. Spheroids have been investigated for decades as models in cancer research, yet we have only just scratched the surface of their potential clinical utility in cell-based therapies. Like many cells, spheroids commonly exhibit a loss of key attributes upon implantation, motivating the need for strategies to regulate their function in situ. Biomaterials offer numerous opportunities to preserve spheroid function and guide spheroid behavior by tailoring the local microenvironment.http://www.sciencedirect.com/science/article/pii/S2666534423000090HydrogelSpheroidAdhesionExtracellular matrixCell-based therapies |
| spellingShingle | David H. Ramos-Rodriguez J. Kent Leach Biomaterials are the key to unlock spheroid function and therapeutic potential Biomaterials and Biosystems Hydrogel Spheroid Adhesion Extracellular matrix Cell-based therapies |
| title | Biomaterials are the key to unlock spheroid function and therapeutic potential |
| title_full | Biomaterials are the key to unlock spheroid function and therapeutic potential |
| title_fullStr | Biomaterials are the key to unlock spheroid function and therapeutic potential |
| title_full_unstemmed | Biomaterials are the key to unlock spheroid function and therapeutic potential |
| title_short | Biomaterials are the key to unlock spheroid function and therapeutic potential |
| title_sort | biomaterials are the key to unlock spheroid function and therapeutic potential |
| topic | Hydrogel Spheroid Adhesion Extracellular matrix Cell-based therapies |
| url | http://www.sciencedirect.com/science/article/pii/S2666534423000090 |
| work_keys_str_mv | AT davidhramosrodriguez biomaterialsarethekeytounlockspheroidfunctionandtherapeuticpotential AT jkentleach biomaterialsarethekeytounlockspheroidfunctionandtherapeuticpotential |