Bioengineered Ferritin Nanocarriers for Cancer Therapy
Ferritin naturally exists in most organisms and can specifically recognize the transferrin 1 receptor (TfR1), which is generally highly expressed on various types of tumor cells. The pH dependent reversible assembling and disassembling property of ferritin renders it as a suitable candidate for enca...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/13/7023 |
| _version_ | 1797411405513621504 |
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| author | Xuanrong Sun Yulu Hong Yubei Gong Shanshan Zheng Dehui Xie |
| author_facet | Xuanrong Sun Yulu Hong Yubei Gong Shanshan Zheng Dehui Xie |
| author_sort | Xuanrong Sun |
| collection | DOAJ |
| description | Ferritin naturally exists in most organisms and can specifically recognize the transferrin 1 receptor (TfR1), which is generally highly expressed on various types of tumor cells. The pH dependent reversible assembling and disassembling property of ferritin renders it as a suitable candidate for encapsulating a variety of anticancer drugs and imaging probes. Ferritins external surface is chemically and genetically modifiable which can serve as attachment site for tumor specific targeting peptides or moieties. Moreover, the biological origin of these protein cages makes it a biocompatible nanocarrier that stabilizes and protects the enclosed particles from the external environment without provoking any toxic or immunogenic responses. Recent studies, further establish ferritin as a multifunctional nanocarrier for targeted cancer chemotherapy and phototherapy. In this review, we introduce the favorable characteristics of ferritin drug carriers, the specific targeted surface modification and a multifunctional nanocarriers combined chemotherapy with phototherapy for tumor treatment. Taken together, ferritin is a potential ideal base of engineered nanoparticles for tumor therapy and still needs to explore more on its way. |
| first_indexed | 2024-03-09T04:45:39Z |
| format | Article |
| id | doaj.art-2350901ec17b46718de9b2aa8b5cc1b2 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T04:45:39Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2350901ec17b46718de9b2aa8b5cc1b22023-12-03T13:15:52ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-06-012213702310.3390/ijms22137023Bioengineered Ferritin Nanocarriers for Cancer TherapyXuanrong Sun0Yulu Hong1Yubei Gong2Shanshan Zheng3Dehui Xie4Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaCollaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, ChinaFerritin naturally exists in most organisms and can specifically recognize the transferrin 1 receptor (TfR1), which is generally highly expressed on various types of tumor cells. The pH dependent reversible assembling and disassembling property of ferritin renders it as a suitable candidate for encapsulating a variety of anticancer drugs and imaging probes. Ferritins external surface is chemically and genetically modifiable which can serve as attachment site for tumor specific targeting peptides or moieties. Moreover, the biological origin of these protein cages makes it a biocompatible nanocarrier that stabilizes and protects the enclosed particles from the external environment without provoking any toxic or immunogenic responses. Recent studies, further establish ferritin as a multifunctional nanocarrier for targeted cancer chemotherapy and phototherapy. In this review, we introduce the favorable characteristics of ferritin drug carriers, the specific targeted surface modification and a multifunctional nanocarriers combined chemotherapy with phototherapy for tumor treatment. Taken together, ferritin is a potential ideal base of engineered nanoparticles for tumor therapy and still needs to explore more on its way.https://www.mdpi.com/1422-0067/22/13/7023ferritintargeted drug deliverysurface modificationcancer therapyphototherapy |
| spellingShingle | Xuanrong Sun Yulu Hong Yubei Gong Shanshan Zheng Dehui Xie Bioengineered Ferritin Nanocarriers for Cancer Therapy International Journal of Molecular Sciences ferritin targeted drug delivery surface modification cancer therapy phototherapy |
| title | Bioengineered Ferritin Nanocarriers for Cancer Therapy |
| title_full | Bioengineered Ferritin Nanocarriers for Cancer Therapy |
| title_fullStr | Bioengineered Ferritin Nanocarriers for Cancer Therapy |
| title_full_unstemmed | Bioengineered Ferritin Nanocarriers for Cancer Therapy |
| title_short | Bioengineered Ferritin Nanocarriers for Cancer Therapy |
| title_sort | bioengineered ferritin nanocarriers for cancer therapy |
| topic | ferritin targeted drug delivery surface modification cancer therapy phototherapy |
| url | https://www.mdpi.com/1422-0067/22/13/7023 |
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