Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis
Objective: To analyze the expression of hypoxia-inducible factor-1α (HIF-1α) and survivin in breast cancer, and different molecular subtypes of breast cancer and to assess their relationship with recurrence and prognosis. Methods: The expression levels of HIF-1α and survivin genes in breast cancer w...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-03-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023013397 |
| _version_ | 1827972592165715968 |
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| author | Qian Cao Munire Mushajiang Cheng-qiong Tang Xiu-qing Ai |
| author_facet | Qian Cao Munire Mushajiang Cheng-qiong Tang Xiu-qing Ai |
| author_sort | Qian Cao |
| collection | DOAJ |
| description | Objective: To analyze the expression of hypoxia-inducible factor-1α (HIF-1α) and survivin in breast cancer, and different molecular subtypes of breast cancer and to assess their relationship with recurrence and prognosis. Methods: The expression levels of HIF-1α and survivin genes in breast cancer were investigated using bioinformatics. Their protein expression levels were then verified through immunohistochemistry (IHC), and their relationship with recurrence and prognosis was assessed. Results: Expression levels of HIF-1α and survivin genes and proteins were increased in breast cancer tissues compared with normal tissues. Both were associated with clinical features of breast cancer and differentially expressed in different molecular subtypes of breast cancer, and both are related to the signal pathway of breast cancer growth and invasion. HIF-1α and survivin gene and protein expression levels were correlated, and both were associated with breast cancer recurrence (R = 0.380, P < 0.05; R = 0.673, P < 0.05, respectively). According to The Cancer Genome Atlas (TCGA) database, HIF1A and BIRC5 gene were not associated with breast cancer prognosis (P ≥ 0.05); however, HIF-1α and survivin protein were associated with recurrence patient's overall survival (OS) (P < 0.05). Conclusion: HIF-1α and survivin are highly expressed in breast cancer and can be used as potential biomarkers to predict recurrence and assess prognosis. |
| first_indexed | 2024-04-09T19:24:11Z |
| format | Article |
| id | doaj.art-23516617200848f4bbdb82be8f45f278 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-09T19:24:11Z |
| publishDate | 2023-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-23516617200848f4bbdb82be8f45f2782023-04-05T08:20:55ZengElsevierHeliyon2405-84402023-03-0193e14132Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosisQian Cao0Munire Mushajiang1Cheng-qiong Tang2Xiu-qing Ai3Department of Breast Radiotherapy, The Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, Xinjiang, ChinaDepartment of Breast Radiotherapy, The Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, Xinjiang, ChinaDepartment of Radiological Physics and Technology, The Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, Xinjiang, ChinaDepartment of Breast Radiotherapy, The Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Urumqi, 830011, Xinjiang, China; Corresponding author. Department of Breast Radiotherapy, The Third Affiliated Teaching Hospital of Xinjiang Medical University(Affiliated Cancer Hospital), No. 789, Suzhou East Street, Xinshi District, Urumqi, 830011 Xinjiang, ChinaObjective: To analyze the expression of hypoxia-inducible factor-1α (HIF-1α) and survivin in breast cancer, and different molecular subtypes of breast cancer and to assess their relationship with recurrence and prognosis. Methods: The expression levels of HIF-1α and survivin genes in breast cancer were investigated using bioinformatics. Their protein expression levels were then verified through immunohistochemistry (IHC), and their relationship with recurrence and prognosis was assessed. Results: Expression levels of HIF-1α and survivin genes and proteins were increased in breast cancer tissues compared with normal tissues. Both were associated with clinical features of breast cancer and differentially expressed in different molecular subtypes of breast cancer, and both are related to the signal pathway of breast cancer growth and invasion. HIF-1α and survivin gene and protein expression levels were correlated, and both were associated with breast cancer recurrence (R = 0.380, P < 0.05; R = 0.673, P < 0.05, respectively). According to The Cancer Genome Atlas (TCGA) database, HIF1A and BIRC5 gene were not associated with breast cancer prognosis (P ≥ 0.05); however, HIF-1α and survivin protein were associated with recurrence patient's overall survival (OS) (P < 0.05). Conclusion: HIF-1α and survivin are highly expressed in breast cancer and can be used as potential biomarkers to predict recurrence and assess prognosis.http://www.sciencedirect.com/science/article/pii/S2405844023013397Breast cancerHIF-1αSurvivinRecurrencePrognosis |
| spellingShingle | Qian Cao Munire Mushajiang Cheng-qiong Tang Xiu-qing Ai Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis Heliyon Breast cancer HIF-1α Survivin Recurrence Prognosis |
| title | Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis |
| title_full | Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis |
| title_fullStr | Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis |
| title_full_unstemmed | Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis |
| title_short | Role of hypoxia-inducible factor-1α and survivin in breast cancer recurrence and prognosis |
| title_sort | role of hypoxia inducible factor 1α and survivin in breast cancer recurrence and prognosis |
| topic | Breast cancer HIF-1α Survivin Recurrence Prognosis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023013397 |
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