Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies
Background The association between common carotid artery intima‐media thickness (CCA‐IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA‐IMT and carotid plaque development. Methods and Results We undertook an indivi...
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-06-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.122.027657 |
| _version_ | 1827920982466101248 |
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| author | Lena Tschiderer Lisa Seekircher Raffaele Izzo Costantino Mancusi Maria V. Manzi Damiano Baldassarre Mauro Amato Elena Tremoli Fabrizio Veglia Tomi‐Pekka Tuomainen Jussi Kauhanen Ari Voutilainen Bernhard Iglseder Lars Lind Tatjana Rundek Moise Desvarieux Akihiko Kato Eric de Groot Gülay Aşçi Ercan Ok Stefan Agewall Joline W. J. Beulens Christopher D. Byrne Philip C. Calder Hertzel C. Gerstein Paolo Gresele Gerhard Klingenschmid Michiaki Nagai Michael H. Olsen Grace Parraga Maya S. Safarova Naveed Sattar Michael Skilton Coen D. A. Stehouwer Heiko Uthoff Michiel A. van Agtmael Amber A. van der Heijden Dorota A. Zozulińska‐Ziółkiewicz Hyun‐Woong Park Moo‐Sik Lee Jang‐Ho Bae Oscar Beloqui Manuel F. Landecho Matthieu Plichart Pierre Ducimetiere Jean Philippe Empana Lena Bokemark Göran Bergström Caroline Schmidt Samuela Castelnuovo Laura Calabresi Giuseppe D. Norata Liliana Grigore Alberico Catapano Dong Zhao Miao Wang Jing Liu M. Arfan Ikram Maryam Kavousi Michiel L. Bots Michael J. Sweeting Matthias W. Lorenz Peter Willeit |
| author_facet | Lena Tschiderer Lisa Seekircher Raffaele Izzo Costantino Mancusi Maria V. Manzi Damiano Baldassarre Mauro Amato Elena Tremoli Fabrizio Veglia Tomi‐Pekka Tuomainen Jussi Kauhanen Ari Voutilainen Bernhard Iglseder Lars Lind Tatjana Rundek Moise Desvarieux Akihiko Kato Eric de Groot Gülay Aşçi Ercan Ok Stefan Agewall Joline W. J. Beulens Christopher D. Byrne Philip C. Calder Hertzel C. Gerstein Paolo Gresele Gerhard Klingenschmid Michiaki Nagai Michael H. Olsen Grace Parraga Maya S. Safarova Naveed Sattar Michael Skilton Coen D. A. Stehouwer Heiko Uthoff Michiel A. van Agtmael Amber A. van der Heijden Dorota A. Zozulińska‐Ziółkiewicz Hyun‐Woong Park Moo‐Sik Lee Jang‐Ho Bae Oscar Beloqui Manuel F. Landecho Matthieu Plichart Pierre Ducimetiere Jean Philippe Empana Lena Bokemark Göran Bergström Caroline Schmidt Samuela Castelnuovo Laura Calabresi Giuseppe D. Norata Liliana Grigore Alberico Catapano Dong Zhao Miao Wang Jing Liu M. Arfan Ikram Maryam Kavousi Michiel L. Bots Michael J. Sweeting Matthias W. Lorenz Peter Willeit |
| author_sort | Lena Tschiderer |
| collection | DOAJ |
| description | Background The association between common carotid artery intima‐media thickness (CCA‐IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA‐IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta‐analysis of 20 prospective studies from the Proof‐ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA‐IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA‐IMT was 0.71 mm (SD, 0.17 mm). Over a median follow‐up of 5.9 years (5th–95th percentile, 1.9–19.0 years), 8278 individuals developed first‐ever carotid plaque. We combined study‐specific odds ratios (ORs) for incident carotid plaque using random‐effects meta‐analysis. Baseline CCA‐IMT was approximately log‐linearly associated with the odds of developing carotid plaque. The age‐, sex‐, and trial arm–adjusted OR for carotid plaque per SD higher baseline CCA‐IMT was 1.40 (95% CI, 1.31–1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low‐ and high‐density lipoprotein cholesterol, and lipid‐lowering and antihypertensive medication was 1.34 (95% CI, 1.24–1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29–1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large‐scale individual participant data meta‐analysis demonstrated that CCA‐IMT is associated with the long‐term risk of developing first‐ever carotid plaque, independent of traditional cardiovascular risk factors. |
| first_indexed | 2024-03-13T04:20:27Z |
| format | Article |
| id | doaj.art-23529eb502664afe812ac7bfbd51a9b2 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-03-13T04:20:27Z |
| publishDate | 2023-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-23529eb502664afe812ac7bfbd51a9b22023-06-20T10:12:26ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802023-06-01121210.1161/JAHA.122.027657Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective StudiesLena Tschiderer0Lisa Seekircher1Raffaele Izzo2Costantino Mancusi3Maria V. Manzi4Damiano Baldassarre5Mauro Amato6Elena Tremoli7Fabrizio Veglia8Tomi‐Pekka Tuomainen9Jussi Kauhanen10Ari Voutilainen11Bernhard Iglseder12Lars Lind13Tatjana Rundek14Moise Desvarieux15Akihiko Kato16Eric de Groot17Gülay Aşçi18Ercan Ok19Stefan Agewall20Joline W. J. Beulens21Christopher D. Byrne22Philip C. Calder23Hertzel C. Gerstein24Paolo Gresele25Gerhard Klingenschmid26Michiaki Nagai27Michael H. Olsen28Grace Parraga29Maya S. Safarova30Naveed Sattar31Michael Skilton32Coen D. A. Stehouwer33Heiko Uthoff34Michiel A. van Agtmael35Amber A. van der Heijden36Dorota A. Zozulińska‐Ziółkiewicz37Hyun‐Woong Park38Moo‐Sik Lee39Jang‐Ho Bae40Oscar Beloqui41Manuel F. Landecho42Matthieu Plichart43Pierre Ducimetiere44Jean Philippe Empana45Lena Bokemark46Göran Bergström47Caroline Schmidt48Samuela Castelnuovo49Laura Calabresi50Giuseppe D. Norata51Liliana Grigore52Alberico Catapano53Dong Zhao54Miao Wang55Jing Liu56M. Arfan Ikram57Maryam Kavousi58Michiel L. Bots59Michael J. Sweeting60Matthias W. Lorenz61Peter Willeit62Institute of Health Economics Medical University of Innsbruck Innsbruck AustriaInstitute of Health Economics Medical University of Innsbruck Innsbruck AustriaDepartment of Advanced Biomedical Sciences Federico II University Naples ItalyDepartment of Advanced Biomedical Sciences Federico II University Naples ItalyDepartment of Advanced Biomedical Sciences Federico II University Naples ItalyDepartment of Medical Biotechnology and Translational Medicine University of Milan Milan ItalyCentro Cardiologico Monzino Stituto di Ricovero e Cura a Carattere Scientifico Milan ItalyMaria Cecilia Hospital Cotignola (Ravenna) ItalyMaria Cecilia Hospital Cotignola (Ravenna) ItalyInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio FinlandInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio FinlandInstitute of Public Health and Clinical Nutrition University of Eastern Finland Kuopio FinlandDepartment of Geriatric Medicine Gemeinnützige Salzburger Landeskliniken Betriebsgesellschaft GmbH Christian‐Doppler‐Klinik Salzburg AustriaDepartment of Medicine Uppsala University Uppsala SwedenDepartment of Neurology University of Miami Miller School of Medicine Miami FLDepartment of Epidemiology, Mailman School of Public Health Columbia University New York NYBlood Purification Unit Hamamatsu University Hospital Hamamatsu JapanImagelabonline and Cardiovascular Erichem the NetherlandsNephrology Department Ege University School of Medicine Bornova‐Izmir TurkeyNephrology Department Ege University School of Medicine Bornova‐Izmir TurkeyDepartment of Clinical Sciences, Danderyd Hospital Division of Cardiology Karolinska Institutet Stockholm SwedenDepartment of Epidemiology and Data Science, Amsterdam University Medical Center–Location Vrije Universiteit Medical Center Amsterdam the NetherlandsSchool of Human Development and Health, Faculty of Medicine University of Southampton Southampton UKSchool of Human Development and Health, Faculty of Medicine University of Southampton Southampton UKDepartment of Medicine and Population Health Research Institute McMaster University Hamilton Ontario CanadaDivision of Internal and Cardiovascular Medicine, Department of Medicine and Surgery University of Perugia Perugia ItalyDepartment of Neurology Medical University of Innsbruck Innsbruck AustriaDepartment of Internal Medicine General Medicine and Cardiology, Hiroshima City Asa Hospital Hiroshima JapanDepartment of Internal Medicine, Holbaek Hospital University of Southern Denmark Odense DenmarkDepartment of Medical Biophysics, Robarts Research Institute Western University London ON CanadaDepartment of Cardiovascular Medicine University of Kansas Medical Center Kansas City KSBritish Heart Foundation Glasgow Cardiovascular Research Centre University of Glasgow Glasgow UKCharles Perkins Centre, Faculty of Medicine and Health University of Sydney Sydney NSW AustraliaDepartment of Internal Medicine and Cardiovascular Research Institute Maastricht Maastricht University Medical Centre Maastricht the NetherlandsDepartment of Angiology University Hospital Basel Basel SwitzerlandDepartment of Internal Medicine Amsterdam University Medical Center, Vrije Universiteit Amsterdam the NetherlandsDepartment of General Practice, Amsterdam University Medical Center–Location Vrije Universiteit Medical Center Amsterdam the NetherlandsDepartment of Internal Medicine and Diabetology Poznan University of Medical Sciences Poznan PolandDivision of Cardiology, Department of Internal Medicine Chungnam National University Sejong Hospital Sejong‐si South KoreaDepartment of Preventive Medicine, College of Medicine Konyang University Daejeon South KoreaHeart Center, Konyang University Hospital Daejeon South KoreaDepartment of Internal Medicine University Clinic of Navarra Navarra SpainDepartment of Internal Medicine University Clinic of Navarra Navarra SpainParis Cardiovascular Research Centre University Paris Descartes Paris FranceFaculty of Medicine University Paris Descartes Paris FranceParis Cardiovascular Research Centre University Paris Descartes Paris FranceWallenberg Laboratory for Cardiovascular Research University of Gothenburg Gothenburg SwedenDepartment of Molecular and Clinical Medicine, Institute of Medicine, Sahlgrenska Academy University of Gothenburg Gothenburg SwedenWallenberg Laboratory for Cardiovascular Research University of Gothenburg Gothenburg SwedenCentro Dislipidemie, Aziende Socio Sanitarie Territoriali Grande Ospedale Metropolitano Niguarda Milan ItalyDepartment of Pharmacological and Biomolecular Sciences University of Milan Milan ItalyDepartment of Pharmacological and Biomolecular Sciences University of Milan Milan ItalyStituto di Ricovero e Cura a Carattere Scientifico Multimedica Milan ItalyDepartment of Pharmacological and Biomolecular Sciences University of Milan Milan ItalyDepartment of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing ChinaDepartment of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing ChinaDepartment of Epidemiology, Beijing Anzhen Hospital Capital Medical University Beijing ChinaDepartment of Epidemiology Erasmus University Medical Center Rotterdam the NetherlandsDepartment of Epidemiology Erasmus University Medical Center Rotterdam the NetherlandsJulius Center for Health Sciences and Primary Care University Medical Center Utrecht Utrecht the NetherlandsDepartment of Health Sciences University of Leicester Leicester UKKlinik für Neurologie Krankenhaus Nordwest Frankfurt am Main GermanyInstitute of Health Economics Medical University of Innsbruck Innsbruck AustriaBackground The association between common carotid artery intima‐media thickness (CCA‐IMT) and incident carotid plaque has not been characterized fully. We therefore aimed to precisely quantify the relationship between CCA‐IMT and carotid plaque development. Methods and Results We undertook an individual participant data meta‐analysis of 20 prospective studies from the Proof‐ATHERO (Prospective Studies of Atherosclerosis) consortium that recorded baseline CCA‐IMT and incident carotid plaque involving 21 494 individuals without a history of cardiovascular disease and without preexisting carotid plaque at baseline. Mean baseline age was 56 years (SD, 9 years), 55% were women, and mean baseline CCA‐IMT was 0.71 mm (SD, 0.17 mm). Over a median follow‐up of 5.9 years (5th–95th percentile, 1.9–19.0 years), 8278 individuals developed first‐ever carotid plaque. We combined study‐specific odds ratios (ORs) for incident carotid plaque using random‐effects meta‐analysis. Baseline CCA‐IMT was approximately log‐linearly associated with the odds of developing carotid plaque. The age‐, sex‐, and trial arm–adjusted OR for carotid plaque per SD higher baseline CCA‐IMT was 1.40 (95% CI, 1.31–1.50; I2=63.9%). The corresponding OR that was further adjusted for ethnicity, smoking, diabetes, body mass index, systolic blood pressure, low‐ and high‐density lipoprotein cholesterol, and lipid‐lowering and antihypertensive medication was 1.34 (95% CI, 1.24–1.45; I2=59.4%; 14 studies; 16 297 participants; 6381 incident plaques). We observed no significant effect modification across clinically relevant subgroups. Sensitivity analysis restricted to studies defining plaque as focal thickening yielded a comparable OR (1.38 [95% CI, 1.29–1.47]; I2=57.1%; 14 studies; 17 352 participants; 6991 incident plaques). Conclusions Our large‐scale individual participant data meta‐analysis demonstrated that CCA‐IMT is associated with the long‐term risk of developing first‐ever carotid plaque, independent of traditional cardiovascular risk factors.https://www.ahajournals.org/doi/10.1161/JAHA.122.027657carotid intima‐media thicknesscarotid plaqueindividual participant data meta‐analysisprospective studies |
| spellingShingle | Lena Tschiderer Lisa Seekircher Raffaele Izzo Costantino Mancusi Maria V. Manzi Damiano Baldassarre Mauro Amato Elena Tremoli Fabrizio Veglia Tomi‐Pekka Tuomainen Jussi Kauhanen Ari Voutilainen Bernhard Iglseder Lars Lind Tatjana Rundek Moise Desvarieux Akihiko Kato Eric de Groot Gülay Aşçi Ercan Ok Stefan Agewall Joline W. J. Beulens Christopher D. Byrne Philip C. Calder Hertzel C. Gerstein Paolo Gresele Gerhard Klingenschmid Michiaki Nagai Michael H. Olsen Grace Parraga Maya S. Safarova Naveed Sattar Michael Skilton Coen D. A. Stehouwer Heiko Uthoff Michiel A. van Agtmael Amber A. van der Heijden Dorota A. Zozulińska‐Ziółkiewicz Hyun‐Woong Park Moo‐Sik Lee Jang‐Ho Bae Oscar Beloqui Manuel F. Landecho Matthieu Plichart Pierre Ducimetiere Jean Philippe Empana Lena Bokemark Göran Bergström Caroline Schmidt Samuela Castelnuovo Laura Calabresi Giuseppe D. Norata Liliana Grigore Alberico Catapano Dong Zhao Miao Wang Jing Liu M. Arfan Ikram Maryam Kavousi Michiel L. Bots Michael J. Sweeting Matthias W. Lorenz Peter Willeit Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease carotid intima‐media thickness carotid plaque individual participant data meta‐analysis prospective studies |
| title | Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies |
| title_full | Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies |
| title_fullStr | Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies |
| title_full_unstemmed | Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies |
| title_short | Association of Intima‐Media Thickness Measured at the Common Carotid Artery With Incident Carotid Plaque: Individual Participant Data Meta‐Analysis of 20 Prospective Studies |
| title_sort | association of intima media thickness measured at the common carotid artery with incident carotid plaque individual participant data meta analysis of 20 prospective studies |
| topic | carotid intima‐media thickness carotid plaque individual participant data meta‐analysis prospective studies |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.122.027657 |
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