Ecological network analysis reveals cancer-dependent chaperone-client interaction structure and robustness
Abstract Cancer cells alter the expression levels of metabolic enzymes to fuel proliferation. The mitochondrion is a central hub of metabolic reprogramming, where chaperones service hundreds of clients, forming chaperone-client interaction networks. How network structure affects its robustness to ch...
Main Authors: | Geut Galai, Xie He, Barak Rotblat, Shai Pilosof |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2023-10-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-023-41906-2 |
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