Evaluation of diallelic STR markers with inter-population allelic database for their usefulness in paternity trios in the Central Indian population
Background Most of the forensic DNA laboratories have migrated to new generation STR kits of 6 dye chemistry with more than 20 autosomal STRs. The population-specific databases of such STR markers are lacking in many regions. Aim To evaluate the effect of the inter-population database in 100 paterni...
| Những tác giả chính: | , , , , , |
|---|---|
| Định dạng: | Bài viết |
| Ngôn ngữ: | English |
| Được phát hành: |
Taylor & Francis Group
2021-11-01
|
| Loạt: | Annals of Human Biology |
| Những chủ đề: | |
| Truy cập trực tuyến: | http://dx.doi.org/10.1080/03014460.2021.2014567 |
| Tóm tắt: | Background Most of the forensic DNA laboratories have migrated to new generation STR kits of 6 dye chemistry with more than 20 autosomal STRs. The population-specific databases of such STR markers are lacking in many regions. Aim To evaluate the effect of the inter-population database in 100 paternity trios with no inconsistencies at 23 STRs. Subjects and methods 100 paternity trios were evaluated considering inter-population allelic frequency values for calculation of Combined Paternity Index (CPI) and Probability of Paternity (POP). Results No significant variation (p < 0.05) among the allele frequencies at the interpopulation level was observed. The number of obligate alleles and the likelihood of transferring obligate alleles from the putative father showed a positive correlation (p < 0.005) with Power of Discrimination (PD), Polymorphic Information Content (PIC), Power of Exclusion (PE), Paternity Index (PI), Observed and Expected Heterozygosity (Ho and He), and a statistically significant negative correlation (p < 0.005) with Matching Probability (Pm). The average Combined Paternity Index (CPI) and Probability of Paternity (POP) did not show any statistically significant difference (p < 0.05) at the interpopulation level. Conclusion The allelic database showed no effect on the CPI and POP in 100 paternity trios. This suggests no urgent need for using population-specific databases for statistical evaluation of paternity trios without inconsistencies. |
|---|---|
| số ISSN: | 0301-4460 1464-5033 |