Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine
Platelet-rich plasma (PRP) has seen increased interest and utilization over the past decade, particularly in the field of musculoskeletal disease. This growth has been accompanied by the development of medical devices to realize PRP preparation which includes blood collection, centrifugation, and PR...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-02-01
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| Series: | Platelets |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/09537104.2020.1832653 |
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| author | Jeremy Magalon Thibault Brandin Pauline Francois Clara Degioanni Lucille De Maria Fanny Grimaud Julie Veran Francoise Dignat-George Florence Sabatier |
| author_facet | Jeremy Magalon Thibault Brandin Pauline Francois Clara Degioanni Lucille De Maria Fanny Grimaud Julie Veran Francoise Dignat-George Florence Sabatier |
| author_sort | Jeremy Magalon |
| collection | DOAJ |
| description | Platelet-rich plasma (PRP) has seen increased interest and utilization over the past decade, particularly in the field of musculoskeletal disease. This growth has been accompanied by the development of medical devices to realize PRP preparation which includes blood collection, centrifugation, and PRP isolation. The final PRP composition is directly influenced by this preparation step and absence of biological quality control led to a lack of comparability between PRP products that could explain the large variability in the clinical benefit of PRP reported in literature. To circumvent this issue, the scientific community developed different PRP classifications but none of them have been adopted. The goal of this review is to furnish both technical and biological characteristics from PRP commercial systems. On review of 1379 studies, 105 studies were selected according to inclusion criteria for technical analysis and led to the identification of 50 commercial systems that have been classified in three technical categories based on the blood harvesting technique (tubes, syringes or bags). Twelve studies were selected and sufficiently describe biological characteristics from only 14 commercial systems from the 50 identified in the technical analysis. Inclusion of duplicates characterization from a same PRP system lead to the final analysis of 36 PRP preparations that met the inclusion criteria of the biological analysis. All these PRP preparations have been classified among the seven existing classifications. Comparison from all biological parameters and classifications revealed a large heterogeneity among the available current PRP commercial systems. Index of biological sensitivity of classifications to distinguish PRP preparations were also variable. Although these findings should help clinicians in selecting a system that meets their specific needs, this also raises the question to standardize the parameters to biologically define PRP preparation among users and to systematically performed PRP qualification when used. |
| first_indexed | 2024-03-12T00:25:57Z |
| format | Article |
| id | doaj.art-2356b1d8fbdf45059420ce2bf9a51a39 |
| institution | Directory Open Access Journal |
| issn | 0953-7104 1369-1635 |
| language | English |
| last_indexed | 2024-03-12T00:25:57Z |
| publishDate | 2021-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Platelets |
| spelling | doaj.art-2356b1d8fbdf45059420ce2bf9a51a392023-09-15T10:38:08ZengTaylor & Francis GroupPlatelets0953-71041369-16352021-02-0132220020810.1080/09537104.2020.18326531832653Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicineJeremy Magalon0Thibault Brandin1Pauline Francois2Clara Degioanni3Lucille De Maria4Fanny Grimaud5Julie Veran6Francoise Dignat-George7Florence Sabatier8Cell Therapy Laboratory, Hôpital De La Conception, AP-HMCell Therapy Laboratory, Hôpital De La Conception, AP-HMCell Therapy Laboratory, Hôpital De La Conception, AP-HMCell Therapy Laboratory, Hôpital De La Conception, AP-HMCell Therapy Laboratory, Hôpital De La Conception, AP-HMCell Therapy Laboratory, Hôpital De La Conception, AP-HMCell Therapy Laboratory, Hôpital De La Conception, AP-HMAix Marseille UnivCell Therapy Laboratory, Hôpital De La Conception, AP-HMPlatelet-rich plasma (PRP) has seen increased interest and utilization over the past decade, particularly in the field of musculoskeletal disease. This growth has been accompanied by the development of medical devices to realize PRP preparation which includes blood collection, centrifugation, and PRP isolation. The final PRP composition is directly influenced by this preparation step and absence of biological quality control led to a lack of comparability between PRP products that could explain the large variability in the clinical benefit of PRP reported in literature. To circumvent this issue, the scientific community developed different PRP classifications but none of them have been adopted. The goal of this review is to furnish both technical and biological characteristics from PRP commercial systems. On review of 1379 studies, 105 studies were selected according to inclusion criteria for technical analysis and led to the identification of 50 commercial systems that have been classified in three technical categories based on the blood harvesting technique (tubes, syringes or bags). Twelve studies were selected and sufficiently describe biological characteristics from only 14 commercial systems from the 50 identified in the technical analysis. Inclusion of duplicates characterization from a same PRP system lead to the final analysis of 36 PRP preparations that met the inclusion criteria of the biological analysis. All these PRP preparations have been classified among the seven existing classifications. Comparison from all biological parameters and classifications revealed a large heterogeneity among the available current PRP commercial systems. Index of biological sensitivity of classifications to distinguish PRP preparations were also variable. Although these findings should help clinicians in selecting a system that meets their specific needs, this also raises the question to standardize the parameters to biologically define PRP preparation among users and to systematically performed PRP qualification when used.http://dx.doi.org/10.1080/09537104.2020.1832653regenerative medecineplatelet-rich-plasma (prp)plateletsquality controlclassification |
| spellingShingle | Jeremy Magalon Thibault Brandin Pauline Francois Clara Degioanni Lucille De Maria Fanny Grimaud Julie Veran Francoise Dignat-George Florence Sabatier Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine Platelets regenerative medecine platelet-rich-plasma (prp) platelets quality control classification |
| title | Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine |
| title_full | Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine |
| title_fullStr | Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine |
| title_full_unstemmed | Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine |
| title_short | Technical and biological review of authorized medical devices for platelets-rich plasma preparation in the field of regenerative medicine |
| title_sort | technical and biological review of authorized medical devices for platelets rich plasma preparation in the field of regenerative medicine |
| topic | regenerative medecine platelet-rich-plasma (prp) platelets quality control classification |
| url | http://dx.doi.org/10.1080/09537104.2020.1832653 |
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