Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection
Background: Both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. Little is known about the relations of serum uric acid (UA) level to regional arterial stiffness and wave reflection. The aim of the study was to investigate the gender-specific associ...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2012-08-01
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| Series: | Iranian Journal of Public Health |
| Subjects: | |
| Online Access: | http://journals.tums.ac.ir/upload_files/pdf/_/21665.pdf |
| _version_ | 1818778319157460992 |
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| author | Suyan Bian Hongyang Guo Ping Ye Leiming Luo Hongmei Wu Wenkai Xiao |
| author_facet | Suyan Bian Hongyang Guo Ping Ye Leiming Luo Hongmei Wu Wenkai Xiao |
| author_sort | Suyan Bian |
| collection | DOAJ |
| description | Background: Both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. Little is known about the relations of serum uric acid (UA) level to regional arterial stiffness and wave reflection. The aim of the study was to investigate the gender-specific association of serum UA and indices of arterial function in a community-based investigation in China.Methods: Cross-sectional data from 2374 adults (mean age 58.24 years) who underwent routine laboratory tests, regional pulse wave velocity (PWV) and pulse wave analysis measurements were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, chronic renal failure, systemic inflammatory disease, gout, or were under treatment which would affect serum UA level.Results: Men had higher serum UA level than women. Subjects with hyperuricaemia had significantly higher carotid-ankle PWV in both genders (P< 0.05), and the carotid-femoral PWV (PWVc-f) was higher in women (P< 0.001) while the augmentation index was marginally lower in men (P = 0.049). Multiple regression analysis showed that serum UA was an independent determinant only for PWVc-f in women (β = 0.104, P = 0.027) when adjusted for atherogenic confounders. No other independent relationship was found between UA level and other surrogates of arterial stiffness.Conclusions: Serum UA levels are associated with alterations in systemic arterial stiffness that differ in men and women. Women might be more susceptible to large vascular damage associated with hyperuricaemia. |
| first_indexed | 2024-12-18T11:42:50Z |
| format | Article |
| id | doaj.art-2358af36679349539b45069ea671eb7d |
| institution | Directory Open Access Journal |
| issn | 2251-6085 |
| language | English |
| last_indexed | 2024-12-18T11:42:50Z |
| publishDate | 2012-08-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Public Health |
| spelling | doaj.art-2358af36679349539b45069ea671eb7d2022-12-21T21:09:23ZengTehran University of Medical SciencesIranian Journal of Public Health2251-60852012-08-014183341Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave ReflectionSuyan BianHongyang GuoPing YeLeiming LuoHongmei WuWenkai XiaoBackground: Both increased arterial stiffness and hyperuricaemia are associated with elevated cardiovascular risks. Little is known about the relations of serum uric acid (UA) level to regional arterial stiffness and wave reflection. The aim of the study was to investigate the gender-specific association of serum UA and indices of arterial function in a community-based investigation in China.Methods: Cross-sectional data from 2374 adults (mean age 58.24 years) who underwent routine laboratory tests, regional pulse wave velocity (PWV) and pulse wave analysis measurements were analyzed in a gender-specific manner. None of the participants had atherosclerotic cardiovascular disease, chronic renal failure, systemic inflammatory disease, gout, or were under treatment which would affect serum UA level.Results: Men had higher serum UA level than women. Subjects with hyperuricaemia had significantly higher carotid-ankle PWV in both genders (P< 0.05), and the carotid-femoral PWV (PWVc-f) was higher in women (P< 0.001) while the augmentation index was marginally lower in men (P = 0.049). Multiple regression analysis showed that serum UA was an independent determinant only for PWVc-f in women (β = 0.104, P = 0.027) when adjusted for atherogenic confounders. No other independent relationship was found between UA level and other surrogates of arterial stiffness.Conclusions: Serum UA levels are associated with alterations in systemic arterial stiffness that differ in men and women. Women might be more susceptible to large vascular damage associated with hyperuricaemia.http://journals.tums.ac.ir/upload_files/pdf/_/21665.pdfArterial StiffnessGenderPublic HealthPulse Wave VelocityUric AcidWave Reflection |
| spellingShingle | Suyan Bian Hongyang Guo Ping Ye Leiming Luo Hongmei Wu Wenkai Xiao Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection Iranian Journal of Public Health Arterial Stiffness Gender Public Health Pulse Wave Velocity Uric Acid Wave Reflection |
| title | Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection |
| title_full | Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection |
| title_fullStr | Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection |
| title_full_unstemmed | Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection |
| title_short | Serum Uric Acid Level and Diverse Impacts on Regional Arterial Stiffness and Wave Reflection |
| title_sort | serum uric acid level and diverse impacts on regional arterial stiffness and wave reflection |
| topic | Arterial Stiffness Gender Public Health Pulse Wave Velocity Uric Acid Wave Reflection |
| url | http://journals.tums.ac.ir/upload_files/pdf/_/21665.pdf |
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