Wnt/beta-catenin pathway: modulating anticancer immune response
Abstract Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical path...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-05-01
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| Series: | Journal of Hematology & Oncology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13045-017-0471-6 |
| _version_ | 1818525222379192320 |
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| author | Sachin Gopalkrishna Pai Benedito A. Carneiro Jose Mauricio Mota Ricardo Costa Caio Abner Leite Romualdo Barroso-Sousa Jason Benjamin Kaplan Young Kwang Chae Francis Joseph Giles |
| author_facet | Sachin Gopalkrishna Pai Benedito A. Carneiro Jose Mauricio Mota Ricardo Costa Caio Abner Leite Romualdo Barroso-Sousa Jason Benjamin Kaplan Young Kwang Chae Francis Joseph Giles |
| author_sort | Sachin Gopalkrishna Pai |
| collection | DOAJ |
| description | Abstract Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway. |
| first_indexed | 2024-12-11T06:06:40Z |
| format | Article |
| id | doaj.art-2359c3182b9b43cfbccf5b6bbbadd951 |
| institution | Directory Open Access Journal |
| issn | 1756-8722 |
| language | English |
| last_indexed | 2024-12-11T06:06:40Z |
| publishDate | 2017-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Hematology & Oncology |
| spelling | doaj.art-2359c3182b9b43cfbccf5b6bbbadd9512022-12-22T01:18:16ZengBMCJournal of Hematology & Oncology1756-87222017-05-0110111210.1186/s13045-017-0471-6Wnt/beta-catenin pathway: modulating anticancer immune responseSachin Gopalkrishna Pai0Benedito A. Carneiro1Jose Mauricio Mota2Ricardo Costa3Caio Abner Leite4Romualdo Barroso-Sousa5Jason Benjamin Kaplan6Young Kwang Chae7Francis Joseph Giles8Developmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of MedicineDevelopmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of MedicineInstituto do Câncer do Estado de São Paulo, University of São PauloDevelopmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of MedicineA.C. Camargo Cancer CenterDepartment of Medical Oncology, Dana-Farber Cancer InstituteDevelopmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of MedicineDevelopmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of MedicineDevelopmental Therapeutics Program, Division of Hematology/Oncology, Feinberg School of MedicineAbstract Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal. The Wnt pathway mediates biological processes by a canonical or noncanonical pathway, depending on the involvement of β-catenin in signal transduction. β-catenin is a core component of the cadherin protein complex, whose stabilization is essential for the activation of Wnt/β-catenin signaling. As multiple aberrations in this pathway occur in numerous cancers, WNT-directed therapy represents an area of significant developmental therapeutics focus. The recently described role of Wnt/β-catenin pathway in regulating immune cell infiltration of the tumor microenvironment renewed the interest, given its potential impact on responses to immunotherapy treatments. This article summarizes the role of Wnt/β-catenin pathway in cancer and ongoing therapeutic strategies involving this pathway.http://link.springer.com/article/10.1186/s13045-017-0471-6Wntβ-cateninImmunotherapyCancer immune regulationImmune exclusion |
| spellingShingle | Sachin Gopalkrishna Pai Benedito A. Carneiro Jose Mauricio Mota Ricardo Costa Caio Abner Leite Romualdo Barroso-Sousa Jason Benjamin Kaplan Young Kwang Chae Francis Joseph Giles Wnt/beta-catenin pathway: modulating anticancer immune response Journal of Hematology & Oncology Wnt β-catenin Immunotherapy Cancer immune regulation Immune exclusion |
| title | Wnt/beta-catenin pathway: modulating anticancer immune response |
| title_full | Wnt/beta-catenin pathway: modulating anticancer immune response |
| title_fullStr | Wnt/beta-catenin pathway: modulating anticancer immune response |
| title_full_unstemmed | Wnt/beta-catenin pathway: modulating anticancer immune response |
| title_short | Wnt/beta-catenin pathway: modulating anticancer immune response |
| title_sort | wnt beta catenin pathway modulating anticancer immune response |
| topic | Wnt β-catenin Immunotherapy Cancer immune regulation Immune exclusion |
| url | http://link.springer.com/article/10.1186/s13045-017-0471-6 |
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