To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study
Background: Oral leukoplakia is a condition commonly associated with tobacco use. The literature also has documentation pertaining to likely cancerous transformation of leukoplakia. It is always a challenge to discover a therapeutic modality to prevent this transformation. Imiquimod is an immune res...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2021-01-01
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| Series: | Journal of Indian Academy of Oral Medicine and Radiology |
| Subjects: | |
| Online Access: | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2021;volume=33;issue=1;spage=27;epage=31;aulast=Mane |
| _version_ | 1819285164564414464 |
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| author | Swati Mane Bhakti Patilsoman Poorvi Bhate Deepa Das Pratik Malusare Nalini Tomar |
| author_facet | Swati Mane Bhakti Patilsoman Poorvi Bhate Deepa Das Pratik Malusare Nalini Tomar |
| author_sort | Swati Mane |
| collection | DOAJ |
| description | Background: Oral leukoplakia is a condition commonly associated with tobacco use. The literature also has documentation pertaining to likely cancerous transformation of leukoplakia. It is always a challenge to discover a therapeutic modality to prevent this transformation. Imiquimod is an immune response modifier possessing antiviral and anti-tumor activity which is being explored as an off label use in many cancerous conditions. Aim: To show any regression in oral leukoplakia and to test its safety and tolerability. Setting and Design: This is a randomized, open-label, single-centered clinical pilot study carried out with Imiquimod. Material and Methods: Two groups OPD of dental college with topical 5% Imiquimod and Topical Vitamin A (50,000 IU) were compared for their efficacy in the management of oral leukoplakia, pre- and post-treatment clinically and regression of oral dysplasia was observed histopathologically. Unit of improvement was noted for assessing the effectiveness of treatment. Statistical Analysis: Quantitative data were analyzed by Wilcoxon signed test. Results: Topical 5% Imiquimod application resulted in good clinical response +1, +2 unit of improvement with more regression of lesion noted in non-homogeneous leukoplakia and areas with less salivary contamination. Topical Imiquimod 5% is the best alternative to conservative management of moderate to severe dysplasia cases where we can offer more to the patient than just observation, and it is also better than a surgical option where surgery leads to more morbidity, in recurrent cases. |
| first_indexed | 2024-12-24T01:58:55Z |
| format | Article |
| id | doaj.art-2359e59aca694ae9a6c1432be1283cbc |
| institution | Directory Open Access Journal |
| issn | 0972-1363 |
| language | English |
| last_indexed | 2024-12-24T01:58:55Z |
| publishDate | 2021-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Indian Academy of Oral Medicine and Radiology |
| spelling | doaj.art-2359e59aca694ae9a6c1432be1283cbc2022-12-21T17:21:29ZengWolters Kluwer Medknow PublicationsJournal of Indian Academy of Oral Medicine and Radiology0972-13632021-01-01331273110.4103/jiaomr.jiaomr_147_20To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot studySwati ManeBhakti PatilsomanPoorvi BhateDeepa DasPratik MalusareNalini TomarBackground: Oral leukoplakia is a condition commonly associated with tobacco use. The literature also has documentation pertaining to likely cancerous transformation of leukoplakia. It is always a challenge to discover a therapeutic modality to prevent this transformation. Imiquimod is an immune response modifier possessing antiviral and anti-tumor activity which is being explored as an off label use in many cancerous conditions. Aim: To show any regression in oral leukoplakia and to test its safety and tolerability. Setting and Design: This is a randomized, open-label, single-centered clinical pilot study carried out with Imiquimod. Material and Methods: Two groups OPD of dental college with topical 5% Imiquimod and Topical Vitamin A (50,000 IU) were compared for their efficacy in the management of oral leukoplakia, pre- and post-treatment clinically and regression of oral dysplasia was observed histopathologically. Unit of improvement was noted for assessing the effectiveness of treatment. Statistical Analysis: Quantitative data were analyzed by Wilcoxon signed test. Results: Topical 5% Imiquimod application resulted in good clinical response +1, +2 unit of improvement with more regression of lesion noted in non-homogeneous leukoplakia and areas with less salivary contamination. Topical Imiquimod 5% is the best alternative to conservative management of moderate to severe dysplasia cases where we can offer more to the patient than just observation, and it is also better than a surgical option where surgery leads to more morbidity, in recurrent cases.http://www.jiaomr.in/article.asp?issn=0972-1363;year=2021;volume=33;issue=1;spage=27;epage=31;aulast=Maneimiquimodnonsurgical managementoral dysplasia |
| spellingShingle | Swati Mane Bhakti Patilsoman Poorvi Bhate Deepa Das Pratik Malusare Nalini Tomar To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study Journal of Indian Academy of Oral Medicine and Radiology imiquimod nonsurgical management oral dysplasia |
| title | To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study |
| title_full | To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study |
| title_fullStr | To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study |
| title_full_unstemmed | To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study |
| title_short | To evaluate the efficacy and tolerability of topical 5% imiquimod in cases of oral leukoplakia: A pilot study |
| title_sort | to evaluate the efficacy and tolerability of topical 5 imiquimod in cases of oral leukoplakia a pilot study |
| topic | imiquimod nonsurgical management oral dysplasia |
| url | http://www.jiaomr.in/article.asp?issn=0972-1363;year=2021;volume=33;issue=1;spage=27;epage=31;aulast=Mane |
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