Micro-patterned cellulose films for flexible electrodes in medical implants
Neuromodulation treatments are based on the functional interface between the brain and man-made electrodes. Chronic inflammation around the implant, however, occurs as a result of mechanical mismatching between soft brain tissue and the stiff metallic electrode. After water uptake, cellulose films s...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2022-08-01
|
| Series: | Micro and Nano Engineering |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590007222000594 |
| _version_ | 1828422364951478272 |
|---|---|
| author | Mahyar Joodaki Bert Müller Helmut Schift Abinaya Nallathambi Bekim Osmani |
| author_facet | Mahyar Joodaki Bert Müller Helmut Schift Abinaya Nallathambi Bekim Osmani |
| author_sort | Mahyar Joodaki |
| collection | DOAJ |
| description | Neuromodulation treatments are based on the functional interface between the brain and man-made electrodes. Chronic inflammation around the implant, however, occurs as a result of mechanical mismatching between soft brain tissue and the stiff metallic electrode. After water uptake, cellulose films should prevent encapsulation of the electrode. In this work, we reinforced cellulose films with silk fibre networks, improving tear strength by a factor of four to seven and maintaining flexibility, characterised by an elastic modulus between 100 and 200 MPa. Whereas sputtered gold on flat films exhibited restricted adhesion, micro-patterning guaranteed reasonable adhesion of nanometre-thin gold to cellulose substrates. Micro-patterned cellulose films coated in 80 nm-thin gold retained conductivity for strains as large as 30%, while sheet resistance increased by a factor of about 30. Fabrication of the biocompatible electrodes is efficient and compatible with large-scale production. |
| first_indexed | 2024-12-10T15:46:23Z |
| format | Article |
| id | doaj.art-235cd00f717f4727b4df7c7bdd454981 |
| institution | Directory Open Access Journal |
| issn | 2590-0072 |
| language | English |
| last_indexed | 2024-12-10T15:46:23Z |
| publishDate | 2022-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Micro and Nano Engineering |
| spelling | doaj.art-235cd00f717f4727b4df7c7bdd4549812022-12-22T01:42:56ZengElsevierMicro and Nano Engineering2590-00722022-08-0116100162Micro-patterned cellulose films for flexible electrodes in medical implantsMahyar Joodaki0Bert Müller1Helmut Schift2Abinaya Nallathambi3Bekim Osmani4Biomaterials Science Center, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, SwitzerlandBiomaterials Science Center, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, Switzerland; Biomaterials Science Center, Department of Clinical Research, University of Basel, 4031 Basel, Switzerland; Corresponding author at: Biomaterials Science Center, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, Switzerland.Laboratory for Nano and Quantum Technologies, Paul Scherrer Institute (PSI), Forschungsstrasse 111, 5232 Villigen PSI, SwitzerlandBiomaterials Science Center, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, SwitzerlandBiomaterials Science Center, Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, 4123 Allschwil, SwitzerlandNeuromodulation treatments are based on the functional interface between the brain and man-made electrodes. Chronic inflammation around the implant, however, occurs as a result of mechanical mismatching between soft brain tissue and the stiff metallic electrode. After water uptake, cellulose films should prevent encapsulation of the electrode. In this work, we reinforced cellulose films with silk fibre networks, improving tear strength by a factor of four to seven and maintaining flexibility, characterised by an elastic modulus between 100 and 200 MPa. Whereas sputtered gold on flat films exhibited restricted adhesion, micro-patterning guaranteed reasonable adhesion of nanometre-thin gold to cellulose substrates. Micro-patterned cellulose films coated in 80 nm-thin gold retained conductivity for strains as large as 30%, while sheet resistance increased by a factor of about 30. Fabrication of the biocompatible electrodes is efficient and compatible with large-scale production.http://www.sciencedirect.com/science/article/pii/S2590007222000594Silk-reinforced cellulose filmGold adhesion via micro-patternMechanical properties of cellulose films in phosphate buffer salineConductivity after cyclic loading |
| spellingShingle | Mahyar Joodaki Bert Müller Helmut Schift Abinaya Nallathambi Bekim Osmani Micro-patterned cellulose films for flexible electrodes in medical implants Micro and Nano Engineering Silk-reinforced cellulose film Gold adhesion via micro-pattern Mechanical properties of cellulose films in phosphate buffer saline Conductivity after cyclic loading |
| title | Micro-patterned cellulose films for flexible electrodes in medical implants |
| title_full | Micro-patterned cellulose films for flexible electrodes in medical implants |
| title_fullStr | Micro-patterned cellulose films for flexible electrodes in medical implants |
| title_full_unstemmed | Micro-patterned cellulose films for flexible electrodes in medical implants |
| title_short | Micro-patterned cellulose films for flexible electrodes in medical implants |
| title_sort | micro patterned cellulose films for flexible electrodes in medical implants |
| topic | Silk-reinforced cellulose film Gold adhesion via micro-pattern Mechanical properties of cellulose films in phosphate buffer saline Conductivity after cyclic loading |
| url | http://www.sciencedirect.com/science/article/pii/S2590007222000594 |
| work_keys_str_mv | AT mahyarjoodaki micropatternedcellulosefilmsforflexibleelectrodesinmedicalimplants AT bertmuller micropatternedcellulosefilmsforflexibleelectrodesinmedicalimplants AT helmutschift micropatternedcellulosefilmsforflexibleelectrodesinmedicalimplants AT abinayanallathambi micropatternedcellulosefilmsforflexibleelectrodesinmedicalimplants AT bekimosmani micropatternedcellulosefilmsforflexibleelectrodesinmedicalimplants |