Association of the TNF-α -308G/A polymorphism with lipid profile changes in response to aerobic training program
Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesityrelated traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine w...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Termedia Publishing House
2019-08-01
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| Series: | Biology of Sport |
| Subjects: | |
| Online Access: | https://www.termedia.pl/Association-of-the-TNF-308G-A-polymorphism-with-lipid-profile-r-nchanges-in-response-to-aerobic-training-program,78,36770,1,1.html |
| Summary: | Promoter polymorphism of the tumor necrosis factor-α (TNF-α) gene is associated with obesityrelated traits, although the role of its potential modifying effect on changes in obesity-related parameters achieved through a training program is still unknown. The aim of the present study was to examine whether the TNF-α-308G/A polymorphism (rs1800629) influences the effects of a training program. Accordingly, we studied the alleles and genotypes distribution in a group of 168 Polish Caucasian women measured for selected body mass and composition, as well as biochemical parameters before and after the realization of a 12-week aerobic training program. Our results showed that TNF-α genotypes can modulate training-induced biochemical parameter changes such as lipid profile. We demonstrated that carriers of the GG genotype are associated with decreases in post-training high-density lipoprotein cholesterol (HDL-C) levels (p<0.001). Additionally, we revealed that participants with the GG genotype had a higher low-density lipoprotein cholesterol (LDL-C) level (p=0.046) during the entire study period. It could be concluded that harboring the GG genotype of rs1800629 may be considered to be a disadvantageous factor in the context of training-induced effects on lipid profile changes in young female participants. |
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| ISSN: | 0860-021X 2083-1862 |