Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease
Celiac disease is a human leukocyte antigen-DQ2 (or DQ8) associated autoimmune disorder of the small intestine induced by dietary exposure to wheat gliadin, barley hordein, rye secalin and possibly oat avenis. It is characterized by mucosal damage, loss of absorptive villi and hyperplasia of the cr...
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| Language: | English |
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Dow University of Health Sciences
2015-04-01
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| Series: | Journal of the Dow University of Health Sciences |
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| Online Access: | https://www.jduhs.com/index.php/jduhs/article/view/1468 |
| _version_ | 1797817544247083008 |
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| author | Samreen Soomro Samina Baig Shaheen Sharafat Talat Mirza |
| author_facet | Samreen Soomro Samina Baig Shaheen Sharafat Talat Mirza |
| author_sort | Samreen Soomro |
| collection | DOAJ |
| description |
Celiac disease is a human leukocyte antigen-DQ2 (or DQ8) associated autoimmune disorder of the small intestine induced by dietary exposure to wheat gliadin, barley hordein, rye secalin and possibly oat avenis.
It is characterized by mucosal damage, loss of absorptive villi and hyperplasia of the crypts leading to malabsorption. In addition, to nutrient deficiencies and growth failure, prolonged untreated celiac disease is associated with an increased risk of malignancy, especially intestinal T cell lymphoma. Tissue transglutaminase antibody tTG antibodies of isotype IgA and IgG is a simple, sensitive and specific noninvasive screening test for diagnosis of celiac disease, particularly in developing countries like Pakistan. In current study from September 2010 to May 2014, samples from 3643 cases referred to Dow Diagnostic Research and Reference
lab were screened for serum IgA and IgG for tissue transglutaminase by ELISA. Results showed that about 1290 patients were anti TtG IgA positive including male and female with a ratio of 1:1.4 respectively, indicating an active stage of the disease. Children (age group between 0 to 16) showed a greater prevalence i.e 37% as compared to other age group. However IgG against tissue transglutaminase didn’t show any significant prevalence pattern.
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| first_indexed | 2024-03-13T08:55:05Z |
| format | Article |
| id | doaj.art-23606378f2dd45fa9ef3d3df2ba44aa2 |
| institution | Directory Open Access Journal |
| issn | 1995-2198 2410-2180 |
| language | English |
| last_indexed | 2024-03-13T08:55:05Z |
| publishDate | 2015-04-01 |
| publisher | Dow University of Health Sciences |
| record_format | Article |
| series | Journal of the Dow University of Health Sciences |
| spelling | doaj.art-23606378f2dd45fa9ef3d3df2ba44aa22023-05-29T03:10:38ZengDow University of Health SciencesJournal of the Dow University of Health Sciences1995-21982410-21802015-04-0191Prevalence of Tissue Transglutamase Antibodies in cases of Celiac DiseaseSamreen Soomro0Samina Baig1Shaheen Sharafat2Talat Mirza3dow university of health and sciences duhsDepartment of Pathology, Dow Diagnostic Reference and Research Lab, Dow University of Health Sciences, Karachi, Pakistan.Dow University of Heath Sciences, Karachi.Dow University of Heath Sciences, Karachi. Celiac disease is a human leukocyte antigen-DQ2 (or DQ8) associated autoimmune disorder of the small intestine induced by dietary exposure to wheat gliadin, barley hordein, rye secalin and possibly oat avenis. It is characterized by mucosal damage, loss of absorptive villi and hyperplasia of the crypts leading to malabsorption. In addition, to nutrient deficiencies and growth failure, prolonged untreated celiac disease is associated with an increased risk of malignancy, especially intestinal T cell lymphoma. Tissue transglutaminase antibody tTG antibodies of isotype IgA and IgG is a simple, sensitive and specific noninvasive screening test for diagnosis of celiac disease, particularly in developing countries like Pakistan. In current study from September 2010 to May 2014, samples from 3643 cases referred to Dow Diagnostic Research and Reference lab were screened for serum IgA and IgG for tissue transglutaminase by ELISA. Results showed that about 1290 patients were anti TtG IgA positive including male and female with a ratio of 1:1.4 respectively, indicating an active stage of the disease. Children (age group between 0 to 16) showed a greater prevalence i.e 37% as compared to other age group. However IgG against tissue transglutaminase didn’t show any significant prevalence pattern. https://www.jduhs.com/index.php/jduhs/article/view/1468Celiac diseaseanti-tissue transglutaminaseanti- glidingastroenteritis |
| spellingShingle | Samreen Soomro Samina Baig Shaheen Sharafat Talat Mirza Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease Journal of the Dow University of Health Sciences Celiac disease anti-tissue transglutaminase anti- glidin gastroenteritis |
| title | Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease |
| title_full | Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease |
| title_fullStr | Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease |
| title_full_unstemmed | Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease |
| title_short | Prevalence of Tissue Transglutamase Antibodies in cases of Celiac Disease |
| title_sort | prevalence of tissue transglutamase antibodies in cases of celiac disease |
| topic | Celiac disease anti-tissue transglutaminase anti- glidin gastroenteritis |
| url | https://www.jduhs.com/index.php/jduhs/article/view/1468 |
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