Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma
Objective This study aimed to identify the effects of beamlet width on dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and determine the optimal parameters for the most effective radiotherapy plan. Methods This study evaluated 20 patients with NPC were selecte...
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| Format: | Article |
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PeerJ Inc.
2022-08-01
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| Online Access: | https://peerj.com/articles/13748.pdf |
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| author | Manya Wu Jinhui Jin Zhenghuan Li Fantu Kong Yadi He Lijiang Liu Wei Yang Xiangying Xu |
| author_facet | Manya Wu Jinhui Jin Zhenghuan Li Fantu Kong Yadi He Lijiang Liu Wei Yang Xiangying Xu |
| author_sort | Manya Wu |
| collection | DOAJ |
| description | Objective This study aimed to identify the effects of beamlet width on dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and determine the optimal parameters for the most effective radiotherapy plan. Methods This study evaluated 20 patients with NPC were selected for dynamic IMRT. Only the beamlet width in the optimization parameters was changed (set to 2, 4, 6, 8, and 10 mm that were named BL02, BL04, BL06, BL08, and BL10, respectively) to optimize the results of the five groups of plans. Using the plan quality scoring system, the dose results of the planning target volumes (PTVs) and organs at risks (OARs) were analyzed objectively and comprehensively. The lower the quality score, the better the quality of the plan. The efficiency and accuracy of plan execution were evaluated using monitor units (MUs) and plan delivery time (PDT). Results The BL04 mm group had the lowest quality score for the targets and OARs (0.087), while the BL10 mm group had the highest total score (1.249). The BL04 mm group had the highest MUs (837 MUs) and longest PDT (358 s). However, the MUs range of each group plan was below 100 MUs, and the PDT range was within 30 s. In the BL02, BL04, BL06, BL08, and BL10 plans, <5 MUs segments accounted for 33%, 16%, 24%, 33%, and 40% of total segments, respectively, with which the lowest was in the BL04 mm group. Conclusion Smaller beamlet widths have not only reduced OARs dose while maintaining high dose coverage to the PTVs, but also lead to more MUs that would produce greater PDT. Considering the quality and efficiency of dynamic IMRT, the beamlet width value of the Monaco treatment planning system set to 4 mm would be optimal for NPC. |
| first_indexed | 2024-03-09T07:11:05Z |
| format | Article |
| id | doaj.art-2363010fd0d5472e82ceedd5b8ac8465 |
| institution | Directory Open Access Journal |
| issn | 2167-8359 |
| language | English |
| last_indexed | 2024-03-09T07:11:05Z |
| publishDate | 2022-08-01 |
| publisher | PeerJ Inc. |
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| series | PeerJ |
| spelling | doaj.art-2363010fd0d5472e82ceedd5b8ac84652023-12-03T09:07:14ZengPeerJ Inc.PeerJ2167-83592022-08-0110e1374810.7717/peerj.13748Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinomaManya Wu0Jinhui Jin1Zhenghuan Li2Fantu Kong3Yadi He4Lijiang Liu5Wei Yang6Xiangying Xu7Department of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, ChinaSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, ChinaDepartment of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, ChinaSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, ChinaSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, ChinaSchool of Biomedical Engineering, Southern Medical University, Guangzhou, Guangdong, ChinaDepartment of Radiation Oncology, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, ChinaObjective This study aimed to identify the effects of beamlet width on dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC) and determine the optimal parameters for the most effective radiotherapy plan. Methods This study evaluated 20 patients with NPC were selected for dynamic IMRT. Only the beamlet width in the optimization parameters was changed (set to 2, 4, 6, 8, and 10 mm that were named BL02, BL04, BL06, BL08, and BL10, respectively) to optimize the results of the five groups of plans. Using the plan quality scoring system, the dose results of the planning target volumes (PTVs) and organs at risks (OARs) were analyzed objectively and comprehensively. The lower the quality score, the better the quality of the plan. The efficiency and accuracy of plan execution were evaluated using monitor units (MUs) and plan delivery time (PDT). Results The BL04 mm group had the lowest quality score for the targets and OARs (0.087), while the BL10 mm group had the highest total score (1.249). The BL04 mm group had the highest MUs (837 MUs) and longest PDT (358 s). However, the MUs range of each group plan was below 100 MUs, and the PDT range was within 30 s. In the BL02, BL04, BL06, BL08, and BL10 plans, <5 MUs segments accounted for 33%, 16%, 24%, 33%, and 40% of total segments, respectively, with which the lowest was in the BL04 mm group. Conclusion Smaller beamlet widths have not only reduced OARs dose while maintaining high dose coverage to the PTVs, but also lead to more MUs that would produce greater PDT. Considering the quality and efficiency of dynamic IMRT, the beamlet width value of the Monaco treatment planning system set to 4 mm would be optimal for NPC.https://peerj.com/articles/13748.pdfIMRTBeamlet widthPlan qualityDelivery efficiencyNPC |
| spellingShingle | Manya Wu Jinhui Jin Zhenghuan Li Fantu Kong Yadi He Lijiang Liu Wei Yang Xiangying Xu Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma PeerJ IMRT Beamlet width Plan quality Delivery efficiency NPC |
| title | Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma |
| title_full | Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma |
| title_fullStr | Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma |
| title_full_unstemmed | Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma |
| title_short | Influence of beamlet width on dynamic IMRT plan quality in nasopharyngeal carcinoma |
| title_sort | influence of beamlet width on dynamic imrt plan quality in nasopharyngeal carcinoma |
| topic | IMRT Beamlet width Plan quality Delivery efficiency NPC |
| url | https://peerj.com/articles/13748.pdf |
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