Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology
Snakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America, <i>B...
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| Format: | Article |
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MDPI AG
2023-07-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/14/11508 |
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| author | Joeliton S. Cavalcante Denis Emanuel Garcia de Almeida Norival A. Santos-Filho Marco Aurélio Sartim Amanda de Almeida Baldo Lisele Brasileiro Polianna L. Albuquerque Sâmella S. Oliveira Jacqueline Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Rui Seabra Ferreira |
| author_facet | Joeliton S. Cavalcante Denis Emanuel Garcia de Almeida Norival A. Santos-Filho Marco Aurélio Sartim Amanda de Almeida Baldo Lisele Brasileiro Polianna L. Albuquerque Sâmella S. Oliveira Jacqueline Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Rui Seabra Ferreira |
| author_sort | Joeliton S. Cavalcante |
| collection | DOAJ |
| description | Snakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America, <i>Bothrops</i> genus snakes are mainly responsible for snakebites in humans, whose pathophysiology is characterized by local and systemic inflammatory and degradative processes, triggering prothrombotic and hemorrhagic events, which lead to various complications, organ damage, tissue loss, amputations, and death. The activation of the multicellular blood system, hemostatic alterations, and activation of the inflammatory response are all well-documented in <i>Bothrops</i> envenomings. However, the interface between inflammation and coagulation is still a neglected issue in the toxinology field. Thromboinflammatory pathways can play a significant role in some of the major complications of snakebite envenoming, such as stroke, venous thromboembolism, and acute kidney injury. In addition to exacerbating inflammation and cell interactions that trigger vaso-occlusion, ischemia–reperfusion processes, and, eventually, organic damage and necrosis. In this review, we discuss the role of inflammatory pathways in modulating coagulation and inducing platelet and leukocyte activation, as well as the inflammatory production mediators and induction of innate immune responses, among other mechanisms that are altered by <i>Bothrops</i> venoms. |
| first_indexed | 2024-03-11T01:00:22Z |
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| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T01:00:22Z |
| publishDate | 2023-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-2363077e0666440c9a6f6c1444b784bc2023-11-18T19:40:45ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-07-0124141150810.3390/ijms241411508Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and PathophysiologyJoeliton S. Cavalcante0Denis Emanuel Garcia de Almeida1Norival A. Santos-Filho2Marco Aurélio Sartim3Amanda de Almeida Baldo4Lisele Brasileiro5Polianna L. Albuquerque6Sâmella S. Oliveira7Jacqueline Almeida Gonçalves Sachett8Wuelton Marcelo Monteiro9Rui Seabra Ferreira10Graduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu 18618-687, São Paulo, BrazilDepartment of Bioprocess and Biotechnology, School of Agriculture, Agronomic Sciences School, São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu 18618-687, São Paulo, BrazilInstitute of Chemistry, São Paulo State University (UNESP—Univ Estadual Paulista), Araraquara 14800-900, São Paulo, BrazilLaboratory of Bioprospection, University Nilton Lins, Manaus 69058-030, Amazonas, BrazilInstitute of Biosciences, São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu 18618-687, São Paulo, BrazilGraduate Program in Tropical Medicine, Department of Research at Fundação de Medicina Tropical Dr. Heitor Vieira Dourado, Amazonas State University, Manaus 69850-000, Amazonas, BrazilToxicological Information and Assistance Center, Instituto Doutor Jose Frota Hospital, Fortaleza 60025-061, Ceará, BrazilResearch Management, Hospital Foundation of Hematology and Hemotherapy of Amazonas, Manaus 69050-001, Amazonas, BrazilResearch & Development Department, Nilton Lins Foundation, Manaus 69058-030, Amazonas, BrazilResearch & Development Department, Nilton Lins Foundation, Manaus 69058-030, Amazonas, BrazilGraduate Program in Tropical Diseases, Botucatu Medical School (FMB), São Paulo State University (UNESP—Univ Estadual Paulista), Botucatu 18618-687, São Paulo, BrazilSnakebite envenoming represents a major health problem in tropical and subtropical countries. Considering the elevated number of accidents and high morbidity and mortality rates, the World Health Organization reclassified this disease to category A of neglected diseases. In Latin America, <i>Bothrops</i> genus snakes are mainly responsible for snakebites in humans, whose pathophysiology is characterized by local and systemic inflammatory and degradative processes, triggering prothrombotic and hemorrhagic events, which lead to various complications, organ damage, tissue loss, amputations, and death. The activation of the multicellular blood system, hemostatic alterations, and activation of the inflammatory response are all well-documented in <i>Bothrops</i> envenomings. However, the interface between inflammation and coagulation is still a neglected issue in the toxinology field. Thromboinflammatory pathways can play a significant role in some of the major complications of snakebite envenoming, such as stroke, venous thromboembolism, and acute kidney injury. In addition to exacerbating inflammation and cell interactions that trigger vaso-occlusion, ischemia–reperfusion processes, and, eventually, organic damage and necrosis. In this review, we discuss the role of inflammatory pathways in modulating coagulation and inducing platelet and leukocyte activation, as well as the inflammatory production mediators and induction of innate immune responses, among other mechanisms that are altered by <i>Bothrops</i> venoms.https://www.mdpi.com/1422-0067/24/14/11508complementhemostasisinflammationneutrophilplateletsnake venom |
| spellingShingle | Joeliton S. Cavalcante Denis Emanuel Garcia de Almeida Norival A. Santos-Filho Marco Aurélio Sartim Amanda de Almeida Baldo Lisele Brasileiro Polianna L. Albuquerque Sâmella S. Oliveira Jacqueline Almeida Gonçalves Sachett Wuelton Marcelo Monteiro Rui Seabra Ferreira Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology International Journal of Molecular Sciences complement hemostasis inflammation neutrophil platelet snake venom |
| title | Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology |
| title_full | Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology |
| title_fullStr | Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology |
| title_full_unstemmed | Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology |
| title_short | Crosstalk of Inflammation and Coagulation in <i>Bothrops</i> Snakebite Envenoming: Endogenous Signaling Pathways and Pathophysiology |
| title_sort | crosstalk of inflammation and coagulation in i bothrops i snakebite envenoming endogenous signaling pathways and pathophysiology |
| topic | complement hemostasis inflammation neutrophil platelet snake venom |
| url | https://www.mdpi.com/1422-0067/24/14/11508 |
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