Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia
Background: Positive effectiveness of antiemetic drugs was approved in reduction of post-operative nausea and vomiting (PONV). The purpose of this study was comparison of dexamethazone, ondansetron and metoclopramide in prevention of post-operative nausea and vomiting. Methods: 210 women candidates...
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| Format: | Article |
| Language: | fas |
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Isfahan University of Medical Sciences
2015-06-01
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| Series: | مجله دانشکده پزشکی اصفهان |
| Subjects: | |
| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/4639 |
| _version_ | 1797718656397869056 |
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| author | Hamidreza Bahmani Seyed Ebrahim Sadeghi Ladan Hosseinipanah |
| author_facet | Hamidreza Bahmani Seyed Ebrahim Sadeghi Ladan Hosseinipanah |
| author_sort | Hamidreza Bahmani |
| collection | DOAJ |
| description | Background: Positive effectiveness of antiemetic drugs was approved in reduction of post-operative nausea and vomiting (PONV). The purpose of this study was comparison of dexamethazone, ondansetron and metoclopramide in prevention of post-operative nausea and vomiting.
Methods: 210 women candidates for elective cesarean section under general anesthesia were divided in to three groups of 70. The groups received ondansetron, dexamethazone or metoclopramide near the end of the surgery. Post-operative nausea and vomiting was evaluated at 0, 2, 4 and 8 hours after the operation. The results were analyzed using Kruskal-Wallis test.
Findings: Injection of all three drugs, ondansetron, metoclopramide and dexamethazane reduced post-operative nausea and vomiting. The rate of reduction of nausea and vomiting was significant in all 3 groups at 4 hours after the surgery. At this time, the dexamethazane group had the highest nausea and vomiting (P = 0.007).
Conclusion: Ondansetron and metoclopramide can be used in the patients with elective cesarean section under general anesthesia for reduction of post-operative nausea and vomiting; the drugs showed more effectiveness with longer duration compared to dexamethasone. |
| first_indexed | 2024-03-12T08:54:33Z |
| format | Article |
| id | doaj.art-236332dd17184860a7160e5e0357f33f |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T08:54:33Z |
| publishDate | 2015-06-01 |
| publisher | Isfahan University of Medical Sciences |
| record_format | Article |
| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-236332dd17184860a7160e5e0357f33f2023-09-02T16:09:49ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2015-06-01333305055141854Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General AnesthesiaHamidreza Bahmani0Seyed Ebrahim Sadeghi1Ladan Hosseinipanah2Assistant Professor, Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranAssistant Professor, Department of Anesthesiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranStudent of Medicine, School of Medicine, International Branch, Shiraz University of Medical Sciences, Shiraz, IranBackground: Positive effectiveness of antiemetic drugs was approved in reduction of post-operative nausea and vomiting (PONV). The purpose of this study was comparison of dexamethazone, ondansetron and metoclopramide in prevention of post-operative nausea and vomiting. Methods: 210 women candidates for elective cesarean section under general anesthesia were divided in to three groups of 70. The groups received ondansetron, dexamethazone or metoclopramide near the end of the surgery. Post-operative nausea and vomiting was evaluated at 0, 2, 4 and 8 hours after the operation. The results were analyzed using Kruskal-Wallis test. Findings: Injection of all three drugs, ondansetron, metoclopramide and dexamethazane reduced post-operative nausea and vomiting. The rate of reduction of nausea and vomiting was significant in all 3 groups at 4 hours after the surgery. At this time, the dexamethazane group had the highest nausea and vomiting (P = 0.007). Conclusion: Ondansetron and metoclopramide can be used in the patients with elective cesarean section under general anesthesia for reduction of post-operative nausea and vomiting; the drugs showed more effectiveness with longer duration compared to dexamethasone.http://jims.mui.ac.ir/index.php/jims/article/view/4639Cesarean sectionDexamethasoneOndansetronMetoclopramideNausea and vomiting |
| spellingShingle | Hamidreza Bahmani Seyed Ebrahim Sadeghi Ladan Hosseinipanah Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia مجله دانشکده پزشکی اصفهان Cesarean section Dexamethasone Ondansetron Metoclopramide Nausea and vomiting |
| title | Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia |
| title_full | Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia |
| title_fullStr | Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia |
| title_full_unstemmed | Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia |
| title_short | Comparison of Prophylactic Antiemetic Effect of Ondansetron, Dexamethasone and Metoclopramide in Cesarean Delivery under General Anesthesia |
| title_sort | comparison of prophylactic antiemetic effect of ondansetron dexamethasone and metoclopramide in cesarean delivery under general anesthesia |
| topic | Cesarean section Dexamethasone Ondansetron Metoclopramide Nausea and vomiting |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/4639 |
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