Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases
ABSTRACT Background: Meningiomas are the most frequent primary central nervous system (CNS) tumors. Their geographical and ethnic characteristics need to be known, in order to enable rational treatment. Objective: To investigate clinical and epidemiological aspects in a series of patients with men...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Academia Brasileira de Neurologia (ABNEURO)
2021-09-01
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| Series: | Arquivos de Neuro-Psiquiatria |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705&tlng=en |
| _version_ | 1819259159157145600 |
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| author | Benedicto Oscar Colli Hélio Rubens Machado Carlos Gilberto Carlotti Jr João Alberto Assirati Jr Ricardo Santos De Oliveira Guilherme Gozzoli Podolsky Gondim Antonio Carlos Dos Santos Luciano Neder |
| author_facet | Benedicto Oscar Colli Hélio Rubens Machado Carlos Gilberto Carlotti Jr João Alberto Assirati Jr Ricardo Santos De Oliveira Guilherme Gozzoli Podolsky Gondim Antonio Carlos Dos Santos Luciano Neder |
| author_sort | Benedicto Oscar Colli |
| collection | DOAJ |
| description | ABSTRACT Background: Meningiomas are the most frequent primary central nervous system (CNS) tumors. Their geographical and ethnic characteristics need to be known, in order to enable rational treatment. Objective: To investigate clinical and epidemiological aspects in a series of patients with meningiomas. Methods: Retrospective analysis on the demographic profile, location and histopathology of 993 patients with meningiomas (768 operated and 225 not operated). Results: Meningiomas represented 43.8% of the primary CNS tumors; 6.8% were multiple tumors (14.7% with neurofibromatosis 2) and 0.6% were radiation-induced tumors. The mean ages were 53.0 and 63.9 years for operated and non-operated patients and the female/male ratios were 3.2:1 and 6.3:1. Diagnosis was made later among females. The peak incidences were in the 6th and 7th decades respectively for operated and non-operated patients. The incidence was low at early ages and higher among patients aged 70+ years. The meningiomas were intracranial in 96.5% and most were WHO grade I (88.9%) and transitional. In the spinal canal (3.5%), they occurred mainly in the dorsal region (all grade I; mostly transitional). The racial distribution was 1.0% in Asian-Brazilians, 87% in Caucasians and 12% in African-Brazilians. 83.4% and 51.6% of the patients were estimated to be recurrence-free at 10 and 20 years, and the mortality rate was 3%. Conclusions: Most of the demographic data were similar to what has been observed in other western centers. Differences were higher incidence of meningiomas, female and older predominance in non-operated patients, predominance in Caucasian, and higher association with neurofibromatosis 2. |
| first_indexed | 2024-12-23T19:05:34Z |
| format | Article |
| id | doaj.art-236467acf99b4878bdbb64960991da33 |
| institution | Directory Open Access Journal |
| issn | 1678-4227 |
| language | English |
| last_indexed | 2024-12-23T19:05:34Z |
| publishDate | 2021-09-01 |
| publisher | Academia Brasileira de Neurologia (ABNEURO) |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj.art-236467acf99b4878bdbb64960991da332022-12-21T17:34:36ZengAcademia Brasileira de Neurologia (ABNEURO)Arquivos de Neuro-Psiquiatria1678-42272021-09-0179870571510.1590/0004-282x-anp-2020-0441Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 casesBenedicto Oscar Collihttps://orcid.org/0000-0002-0222-6770Hélio Rubens Machadohttps://orcid.org/0000-0002-1069-7804Carlos Gilberto Carlotti Jrhttps://orcid.org/0000-0002-7055-0564João Alberto Assirati Jrhttps://orcid.org/0000-0001-6772-2129Ricardo Santos De Oliveirahttps://orcid.org/0000-0003-0390-5553Guilherme Gozzoli Podolsky Gondimhttps://orcid.org/0000-0002-9608-2607Antonio Carlos Dos Santoshttps://orcid.org/0000-0002-5502-4734Luciano Nederhttps://orcid.org/0000-0003-3790-3476ABSTRACT Background: Meningiomas are the most frequent primary central nervous system (CNS) tumors. Their geographical and ethnic characteristics need to be known, in order to enable rational treatment. Objective: To investigate clinical and epidemiological aspects in a series of patients with meningiomas. Methods: Retrospective analysis on the demographic profile, location and histopathology of 993 patients with meningiomas (768 operated and 225 not operated). Results: Meningiomas represented 43.8% of the primary CNS tumors; 6.8% were multiple tumors (14.7% with neurofibromatosis 2) and 0.6% were radiation-induced tumors. The mean ages were 53.0 and 63.9 years for operated and non-operated patients and the female/male ratios were 3.2:1 and 6.3:1. Diagnosis was made later among females. The peak incidences were in the 6th and 7th decades respectively for operated and non-operated patients. The incidence was low at early ages and higher among patients aged 70+ years. The meningiomas were intracranial in 96.5% and most were WHO grade I (88.9%) and transitional. In the spinal canal (3.5%), they occurred mainly in the dorsal region (all grade I; mostly transitional). The racial distribution was 1.0% in Asian-Brazilians, 87% in Caucasians and 12% in African-Brazilians. 83.4% and 51.6% of the patients were estimated to be recurrence-free at 10 and 20 years, and the mortality rate was 3%. Conclusions: Most of the demographic data were similar to what has been observed in other western centers. Differences were higher incidence of meningiomas, female and older predominance in non-operated patients, predominance in Caucasian, and higher association with neurofibromatosis 2.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705&tlng=enMeningiomaDemographic DataPathologyGeneral SurgeryRisk FactorsNeoplasm Recurrence, Local |
| spellingShingle | Benedicto Oscar Colli Hélio Rubens Machado Carlos Gilberto Carlotti Jr João Alberto Assirati Jr Ricardo Santos De Oliveira Guilherme Gozzoli Podolsky Gondim Antonio Carlos Dos Santos Luciano Neder Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases Arquivos de Neuro-Psiquiatria Meningioma Demographic Data Pathology General Surgery Risk Factors Neoplasm Recurrence, Local |
| title | Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
| title_full | Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
| title_fullStr | Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
| title_full_unstemmed | Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
| title_short | Epidemiological features of meningiomas: a single Brazilian center’s experience with 993 cases |
| title_sort | epidemiological features of meningiomas a single brazilian center s experience with 993 cases |
| topic | Meningioma Demographic Data Pathology General Surgery Risk Factors Neoplasm Recurrence, Local |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2021000800705&tlng=en |
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