CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon.
The aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 20...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2017-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5667869?pdf=render |
| _version_ | 1818292920038457344 |
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| author | Luiz Fábio Magno Falcão Aline Semblano Carreira Falcão Rita Catarina Medeiros Sousa Waldônio de Brito Vieira Robson Tadachi Moraes de Oliveira Valéria Marques Ferreira Normando George Alberto da Silva Dias Marcio Clementino de Souza Santos Rodrigo Santiago Barbosa Rocha Gilberto Toshimitsu Yoshikawa Roberta Vilela Lopes Koyama Satomi Fujihara Víctor Augusto Cavaleiro Corrêa Hellen Thais Fuzii Juarez Antônio Simões Quaresma |
| author_facet | Luiz Fábio Magno Falcão Aline Semblano Carreira Falcão Rita Catarina Medeiros Sousa Waldônio de Brito Vieira Robson Tadachi Moraes de Oliveira Valéria Marques Ferreira Normando George Alberto da Silva Dias Marcio Clementino de Souza Santos Rodrigo Santiago Barbosa Rocha Gilberto Toshimitsu Yoshikawa Roberta Vilela Lopes Koyama Satomi Fujihara Víctor Augusto Cavaleiro Corrêa Hellen Thais Fuzii Juarez Antônio Simões Quaresma |
| author_sort | Luiz Fábio Magno Falcão |
| collection | DOAJ |
| description | The aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 2013 and June 2016, we included 48 patients with HAM/TSP (19 women and 11 men) and without HAM/TSP (12 women and 6 men). We compared CT findings and lung functions of these groups. Patients who had HAM/TSP had abnormal CT findings (P = 0.000), including more frequent bronchiectasis (P = 0.049), parenchymal bands (P = 0.007), interlobular septal thickening (P = 0.035), and pleural thickening (P = 0.009). In addition, neither patients with HAM/TSP (9/30; 30%) nor the controls (0/18; 0%) had obstructive or restrictive lung disease (P = 0.009). HTLV diagnosis should be considered in all patients with abnormal CT findings in whom no other cause is apparent. It is important to remember that lung disease increases the rates of morbidity and mortality in developing countries. |
| first_indexed | 2024-12-13T03:07:37Z |
| format | Article |
| id | doaj.art-236482434dd543508ccfa80cd727e946 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-13T03:07:37Z |
| publishDate | 2017-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-236482434dd543508ccfa80cd727e9462022-12-22T00:01:40ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011211e018605510.1371/journal.pone.0186055CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon.Luiz Fábio Magno FalcãoAline Semblano Carreira FalcãoRita Catarina Medeiros SousaWaldônio de Brito VieiraRobson Tadachi Moraes de OliveiraValéria Marques Ferreira NormandoGeorge Alberto da Silva DiasMarcio Clementino de Souza SantosRodrigo Santiago Barbosa RochaGilberto Toshimitsu YoshikawaRoberta Vilela Lopes KoyamaSatomi FujiharaVíctor Augusto Cavaleiro CorrêaHellen Thais FuziiJuarez Antônio Simões QuaresmaThe aim of this study was to compare computed tomography (CT) scans of chest and lung function among patients with Human T-Lymphotropic Virus Type 1 (HTLV) with and without HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). In this cross-sectional study performed between January 2013 and June 2016, we included 48 patients with HAM/TSP (19 women and 11 men) and without HAM/TSP (12 women and 6 men). We compared CT findings and lung functions of these groups. Patients who had HAM/TSP had abnormal CT findings (P = 0.000), including more frequent bronchiectasis (P = 0.049), parenchymal bands (P = 0.007), interlobular septal thickening (P = 0.035), and pleural thickening (P = 0.009). In addition, neither patients with HAM/TSP (9/30; 30%) nor the controls (0/18; 0%) had obstructive or restrictive lung disease (P = 0.009). HTLV diagnosis should be considered in all patients with abnormal CT findings in whom no other cause is apparent. It is important to remember that lung disease increases the rates of morbidity and mortality in developing countries.http://europepmc.org/articles/PMC5667869?pdf=render |
| spellingShingle | Luiz Fábio Magno Falcão Aline Semblano Carreira Falcão Rita Catarina Medeiros Sousa Waldônio de Brito Vieira Robson Tadachi Moraes de Oliveira Valéria Marques Ferreira Normando George Alberto da Silva Dias Marcio Clementino de Souza Santos Rodrigo Santiago Barbosa Rocha Gilberto Toshimitsu Yoshikawa Roberta Vilela Lopes Koyama Satomi Fujihara Víctor Augusto Cavaleiro Corrêa Hellen Thais Fuzii Juarez Antônio Simões Quaresma CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon. PLoS ONE |
| title | CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon. |
| title_full | CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon. |
| title_fullStr | CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon. |
| title_full_unstemmed | CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon. |
| title_short | CT Chest and pulmonary functional changes in patients with HTLV-associated myelopathy in the Eastern Brazilian Amazon. |
| title_sort | ct chest and pulmonary functional changes in patients with htlv associated myelopathy in the eastern brazilian amazon |
| url | http://europepmc.org/articles/PMC5667869?pdf=render |
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