GENETIC ASPECTS OF ENDOMETRIAL CANCER
Whether endometrial cancer (EC) is associated with different allele variants of genes of the detoxification system of xenobiotics has been studied and analyzed. The study has been conducted on a sufficient number of patients (102 and 149 women in the study and control groups, respectively). The meth...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-09-01
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| Series: | Опухоли женской репродуктивной системы |
| Subjects: | |
| Online Access: | https://ojrs.abvpress.ru/ojrs/article/view/295 |
| _version_ | 1797876055915102208 |
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| author | V. A. Pushkarev V. A. Kulavsky T. V. Viktorova G. M. Iskhakova E. V. Kulavsky |
| author_facet | V. A. Pushkarev V. A. Kulavsky T. V. Viktorova G. M. Iskhakova E. V. Kulavsky |
| author_sort | V. A. Pushkarev |
| collection | DOAJ |
| description | Whether endometrial cancer (EC) is associated with different allele variants of genes of the detoxification system of xenobiotics has been studied and analyzed. The study has been conducted on a sufficient number of patients (102 and 149 women in the study and control groups, respectively). The methods used have been quite adequate to solve the set task.There are significant differences in the distribution of the frequency of genomes of the GSTM1 gene between patients with EC and the controls (χ2 =3.9, p = 005).Homozygous carriers of GSTP1 gene mutation in EC patients are encountered more frequently in the control group (5.9 and 3.4%, respectively), which shows the increased probability of EC in women with this genotype; heterozygous carriers of mutation with Ile/Val genotype are also identified more frequently in EC patients (47.05 %) than those in the control group (33.5; p = 0.04); the odds ratio was 1.76, which suggests a high risk of EC. |
| first_indexed | 2024-04-10T01:57:16Z |
| format | Article |
| id | doaj.art-23650e9c80e549f397620ce2323f63f7 |
| institution | Directory Open Access Journal |
| issn | 1994-4098 1999-8627 |
| language | Russian |
| last_indexed | 2024-04-10T01:57:16Z |
| publishDate | 2014-09-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Опухоли женской репродуктивной системы |
| spelling | doaj.art-23650e9c80e549f397620ce2323f63f72023-03-13T08:44:34ZrusABV-pressОпухоли женской репродуктивной системы1994-40981999-86272014-09-0101-2727510.17650/1994-4098-2009-0-1-2-72-75311GENETIC ASPECTS OF ENDOMETRIAL CANCERV. A. Pushkarev0V. A. Kulavsky1T. V. Viktorova2G. M. Iskhakova3E. V. Kulavsky4Кафедры акушерства и гинекологии и биологии Башкирского государственного медицинского университета, Республиканский клинический онкологический диспансер МЗ Республики БашкортостанКафедры акушерства и гинекологии и биологии Башкирского государственного медицинского университета, Республиканский клинический онкологический диспансер МЗ Республики БашкортостанКафедры акушерства и гинекологии и биологии Башкирского государственного медицинского университета, Республиканский клинический онкологический диспансер МЗ Республики БашкортостанКафедры акушерства и гинекологии и биологии Башкирского государственного медицинского университета, Республиканский клинический онкологический диспансер МЗ Республики БашкортостанКафедры акушерства и гинекологии и биологии Башкирского государственного медицинского университета, Республиканский клинический онкологический диспансер МЗ Республики БашкортостанWhether endometrial cancer (EC) is associated with different allele variants of genes of the detoxification system of xenobiotics has been studied and analyzed. The study has been conducted on a sufficient number of patients (102 and 149 women in the study and control groups, respectively). The methods used have been quite adequate to solve the set task.There are significant differences in the distribution of the frequency of genomes of the GSTM1 gene between patients with EC and the controls (χ2 =3.9, p = 005).Homozygous carriers of GSTP1 gene mutation in EC patients are encountered more frequently in the control group (5.9 and 3.4%, respectively), which shows the increased probability of EC in women with this genotype; heterozygous carriers of mutation with Ile/Val genotype are also identified more frequently in EC patients (47.05 %) than those in the control group (33.5; p = 0.04); the odds ratio was 1.76, which suggests a high risk of EC.https://ojrs.abvpress.ru/ojrs/article/view/295рак эндометриядетоксикация ксенобиотиковмутации |
| spellingShingle | V. A. Pushkarev V. A. Kulavsky T. V. Viktorova G. M. Iskhakova E. V. Kulavsky GENETIC ASPECTS OF ENDOMETRIAL CANCER Опухоли женской репродуктивной системы рак эндометрия детоксикация ксенобиотиков мутации |
| title | GENETIC ASPECTS OF ENDOMETRIAL CANCER |
| title_full | GENETIC ASPECTS OF ENDOMETRIAL CANCER |
| title_fullStr | GENETIC ASPECTS OF ENDOMETRIAL CANCER |
| title_full_unstemmed | GENETIC ASPECTS OF ENDOMETRIAL CANCER |
| title_short | GENETIC ASPECTS OF ENDOMETRIAL CANCER |
| title_sort | genetic aspects of endometrial cancer |
| topic | рак эндометрия детоксикация ксенобиотиков мутации |
| url | https://ojrs.abvpress.ru/ojrs/article/view/295 |
| work_keys_str_mv | AT vapushkarev geneticaspectsofendometrialcancer AT vakulavsky geneticaspectsofendometrialcancer AT tvviktorova geneticaspectsofendometrialcancer AT gmiskhakova geneticaspectsofendometrialcancer AT evkulavsky geneticaspectsofendometrialcancer |