An enhanced antioxidant strategy of astaxanthin encapsulated in ROS-responsive nanoparticles for combating cisplatin-induced ototoxicity

An enhanced antioxidant strategy of astaxanthin encapsulated in ROS-responsive nanoparticles for combating cisplatin-induced ototoxicity

Abstract Background Excessive accumulation of reactive oxygen species (ROS) has been documented as the crucial cellular mechanism of cisplatin-induced ototoxicity. However, numerous antioxidants have failed in clinical studies partly due to inefficient drug delivery to the cochlea. A drug delivery s...

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Bibliographic Details
Main Authors: Jiayi Gu, Xueling Wang, Yuming Chen, Ke Xu, Dehong Yu, Hao Wu
Format: Article
Language:English
Published: BMC 2022-06-01
Series:Journal of Nanobiotechnology
Subjects:
ROS-responsive
Poly(propylene sulfide)
Astaxanthin
Cisplatin-induced ototoxicity
Online Access:https://doi.org/10.1186/s12951-022-01485-8

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