Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study
Objective:To compare efficacy and safety of recombinant follicule stimulating hormone (r-FSH) and highly purified urinary FSH (HPuFSH) in polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI).Method:This was a prospective randomized study conducted at Kocaeli U...
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| Format: | Article |
| Language: | English |
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Galenos Yayinevi
2022-03-01
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| Series: | Bagcilar Medical Bulletin |
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http://behmedicalbulletin.org/archives/archive-detail/article-preview/recombinant-fsh-versus-highly-purified-urinary-fsh/51250
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| _version_ | 1797912629195309056 |
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| author | Öner Aynıoğlu Yasin Ceylan Bertan Akar Sebiha Özdemir Özkan Eray Çalışkan Emek Doğer Yiğit Çakıroğlu |
| author_facet | Öner Aynıoğlu Yasin Ceylan Bertan Akar Sebiha Özdemir Özkan Eray Çalışkan Emek Doğer Yiğit Çakıroğlu |
| author_sort | Öner Aynıoğlu |
| collection | DOAJ |
| description | Objective:To compare efficacy and safety of recombinant follicule stimulating hormone (r-FSH) and highly purified urinary FSH (HPuFSH) in polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI).Method:This was a prospective randomized study conducted at Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology, in vitro fertizilization (IVF) Unit. A total of 91 PCOS patients undergoing ICSI were randomly assigned to receive either r-FSH (n=46) or HPuFSH (n=45) with a gonadotropin releasing hormone (GnRH) antagonist protocol. The main outcome measures were the number of mature oocytes retrieved, embryo quality, pregnancy rates, implantation rates.Results:The number of mature oocytes retrieved, fertilization rates, the number of cryopreserved embryos were significantly higher in r-FSH group (p=0.024, p=0.023, p=0.026 respectively) while the total dose of FSH used was significantly lower in the same group (p=0.023). Pregnancy rates, clinical pregnancy rates were higher in r-FSH group although not statistically significant (52.2% versus 35.6%, p=0.11, 37% versus 28.9%, p=0.41 respectively). Overall therapy costs per clinical pregnancy were associated with a 9.94% increase in r-FSH group whereas costs per pregnancy were not different between groups.Conclusion:r-FSH is superior than HP-uFSH in PCOS regarding fertilization rates, the number of mature oocytes retrieved and cryopreserved embryos, pregnancy rates although overall therapy costs per clinical pregnancy are higher. |
| first_indexed | 2024-04-10T12:00:03Z |
| format | Article |
| id | doaj.art-23659af0074e415a893d837137969f1f |
| institution | Directory Open Access Journal |
| issn | 2547-9431 |
| language | English |
| last_indexed | 2024-04-10T12:00:03Z |
| publishDate | 2022-03-01 |
| publisher | Galenos Yayinevi |
| record_format | Article |
| series | Bagcilar Medical Bulletin |
| spelling | doaj.art-23659af0074e415a893d837137969f1f2023-02-15T16:16:40ZengGalenos YayineviBagcilar Medical Bulletin2547-94312022-03-0171636910.4274/BMB.galenos.2022.2021-05-05713049054Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized StudyÖner Aynıoğlu0Yasin Ceylan1Bertan Akar2Sebiha Özdemir Özkan3Eray Çalışkan4Emek Doğer5Yiğit Çakıroğlu6 Private Kocaeli Hospital, Clinic of Obstetrics and Gynecology, Kocaeli, Turkey University of Health Sciences Turkey, İstanbul Bağcılar Training and Research Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey İstinye University Faculty of Medicine; Private Kocaeli Hospital, Clinic of Obstetrics and Gynecology, Kocaeli, Turkey Medicalpark Kocaeli Hospital, Clinic of Obstetrics and Gynecology, Kocaeli, Turkey Okan University Faculty of Medicine, Department of Obstetrics and Gynecology, İstanbul, Turkey Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology, Kocaeli, Turkey Acıbadem Maslak Hospital, Clinic of Obstetrics and Gynecology, İstanbul, Turkey Objective:To compare efficacy and safety of recombinant follicule stimulating hormone (r-FSH) and highly purified urinary FSH (HPuFSH) in polycystic ovary syndrome (PCOS) patients undergoing intracytoplasmic sperm injection (ICSI).Method:This was a prospective randomized study conducted at Kocaeli University Faculty of Medicine, Department of Obstetrics and Gynecology, in vitro fertizilization (IVF) Unit. A total of 91 PCOS patients undergoing ICSI were randomly assigned to receive either r-FSH (n=46) or HPuFSH (n=45) with a gonadotropin releasing hormone (GnRH) antagonist protocol. The main outcome measures were the number of mature oocytes retrieved, embryo quality, pregnancy rates, implantation rates.Results:The number of mature oocytes retrieved, fertilization rates, the number of cryopreserved embryos were significantly higher in r-FSH group (p=0.024, p=0.023, p=0.026 respectively) while the total dose of FSH used was significantly lower in the same group (p=0.023). Pregnancy rates, clinical pregnancy rates were higher in r-FSH group although not statistically significant (52.2% versus 35.6%, p=0.11, 37% versus 28.9%, p=0.41 respectively). Overall therapy costs per clinical pregnancy were associated with a 9.94% increase in r-FSH group whereas costs per pregnancy were not different between groups.Conclusion:r-FSH is superior than HP-uFSH in PCOS regarding fertilization rates, the number of mature oocytes retrieved and cryopreserved embryos, pregnancy rates although overall therapy costs per clinical pregnancy are higher. http://behmedicalbulletin.org/archives/archive-detail/article-preview/recombinant-fsh-versus-highly-purified-urinary-fsh/51250 arthp-ufshpcosrec-fsh |
| spellingShingle | Öner Aynıoğlu Yasin Ceylan Bertan Akar Sebiha Özdemir Özkan Eray Çalışkan Emek Doğer Yiğit Çakıroğlu Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study Bagcilar Medical Bulletin art hp-ufsh pcos rec-fsh |
| title | Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study |
| title_full | Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study |
| title_fullStr | Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study |
| title_full_unstemmed | Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study |
| title_short | Recombinant FSH Versus Highly Purified Urinary FSH in Patients with Polycystic Ovary Syndrome Undergoing ICSI Cycles: A Prospective Randomized Study |
| title_sort | recombinant fsh versus highly purified urinary fsh in patients with polycystic ovary syndrome undergoing icsi cycles a prospective randomized study |
| topic | art hp-ufsh pcos rec-fsh |
| url |
http://behmedicalbulletin.org/archives/archive-detail/article-preview/recombinant-fsh-versus-highly-purified-urinary-fsh/51250
|
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