The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study
Tualang honey (蜂蜜 Fēng Mì) is known to have anti-inflammatory property, but its antinociceptive property has not been extensively investigated. In this study, we examined the preemptive effects on administering different doses of Tualang honey and prednisolone on the nociceptive response in male Spr...
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| Format: | Article |
| Language: | English |
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Elsevier
2014-10-01
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| Series: | Journal of Traditional and Complementary Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2225411016302498 |
| _version_ | 1818119607255302144 |
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| author | Che Badariah Abd Aziz Che Aishah Nazariah Ismail Che Maraina Che Hussin Mahaneem Mohamed |
| author_facet | Che Badariah Abd Aziz Che Aishah Nazariah Ismail Che Maraina Che Hussin Mahaneem Mohamed |
| author_sort | Che Badariah Abd Aziz |
| collection | DOAJ |
| description | Tualang honey (蜂蜜 Fēng Mì) is known to have anti-inflammatory property, but its antinociceptive property has not been extensively investigated. In this study, we examined the preemptive effects on administering different doses of Tualang honey and prednisolone on the nociceptive response in male Sprague-Dawley rats. Thirty-five male Sprague-Dawley rats were randomized into five groups (n=7) and each group received either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days. The response to noxious thermal stimulus was assessed using tail flick test on Day 10. The well-being of the rats was also assessed by monitoring their food intake and body weight. Data were analyzed using one-way Analysis of Variance (ANOVA) with post-hoc Scheffe's test and P value less than 0.05 was considered significant. In tail flick test, the tail flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group (P<0.05). There was significant reduction in the total food pellet intake in the groups receiving prednisolone and Tualang honey (1.2 g/kg and 2.4 g/kg) compared to controls; however, the body weight gain was only significantly reduced in the prednisolone group. All the parameters were not significantly affected in the group receiving 0.2 g/kg of Tualang honey. In conclusion, preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses. The reduced weight gain in the prednisolone group is an unwanted effect due to its metabolic and central actions. Further studies are required to confirm the antinociceptive effects and elucidate the mechanism of antinociceptive action of Tualang honey in the rats. |
| first_indexed | 2024-12-11T05:12:53Z |
| format | Article |
| id | doaj.art-2365e76e257740a4b202bad600f89962 |
| institution | Directory Open Access Journal |
| issn | 2225-4110 |
| language | English |
| last_indexed | 2024-12-11T05:12:53Z |
| publishDate | 2014-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Traditional and Complementary Medicine |
| spelling | doaj.art-2365e76e257740a4b202bad600f899622022-12-22T01:19:52ZengElsevierJournal of Traditional and Complementary Medicine2225-41102014-10-014429830210.4103/2225-4110.139115The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary StudyChe Badariah Abd Aziz0Che Aishah Nazariah Ismail1Che Maraina Che Hussin2Mahaneem Mohamed3Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.Department of Immunology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia, 16150 Kubang Kerian, Kota Bharu, Kelantan, Malaysia.Tualang honey (蜂蜜 Fēng Mì) is known to have anti-inflammatory property, but its antinociceptive property has not been extensively investigated. In this study, we examined the preemptive effects on administering different doses of Tualang honey and prednisolone on the nociceptive response in male Sprague-Dawley rats. Thirty-five male Sprague-Dawley rats were randomized into five groups (n=7) and each group received either distilled water, Tualang honey (0.2, 1.2 or 2.4 g/kg) or prednisolone (10 mg/kg) for 10 days. The response to noxious thermal stimulus was assessed using tail flick test on Day 10. The well-being of the rats was also assessed by monitoring their food intake and body weight. Data were analyzed using one-way Analysis of Variance (ANOVA) with post-hoc Scheffe's test and P value less than 0.05 was considered significant. In tail flick test, the tail flick latency time was significantly higher in the groups that received 1.2 g/kg and 2.4 g/kg of Tualang honey and 10 mg/kg of prednisolone, compared to the control group (P<0.05). There was significant reduction in the total food pellet intake in the groups receiving prednisolone and Tualang honey (1.2 g/kg and 2.4 g/kg) compared to controls; however, the body weight gain was only significantly reduced in the prednisolone group. All the parameters were not significantly affected in the group receiving 0.2 g/kg of Tualang honey. In conclusion, preemptive administration of Tualang honey (1.2 g/kg and 2.4 g/kg) and prednisolone (10 mg/kg) had reduced the pain responses. The reduced weight gain in the prednisolone group is an unwanted effect due to its metabolic and central actions. Further studies are required to confirm the antinociceptive effects and elucidate the mechanism of antinociceptive action of Tualang honey in the rats.http://www.sciencedirect.com/science/article/pii/S2225411016302498Body weightFood intakePrednisoloneTail flick testTualang honey |
| spellingShingle | Che Badariah Abd Aziz Che Aishah Nazariah Ismail Che Maraina Che Hussin Mahaneem Mohamed The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study Journal of Traditional and Complementary Medicine Body weight Food intake Prednisolone Tail flick test Tualang honey |
| title | The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study |
| title_full | The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study |
| title_fullStr | The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study |
| title_full_unstemmed | The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study |
| title_short | The Antinociceptive Effects of Tualang Honey in Male Sprague-Dawley Rats: A Preliminary Study |
| title_sort | antinociceptive effects of tualang honey in male sprague dawley rats a preliminary study |
| topic | Body weight Food intake Prednisolone Tail flick test Tualang honey |
| url | http://www.sciencedirect.com/science/article/pii/S2225411016302498 |
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