Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger
Cardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recovery in CVD patients. Nevertheless, elusive and multifactorial p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2021.767488/full |
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| author | Anshul S. Jadli Anshul S. Jadli Ananya Parasor Ananya Parasor Karina P. Gomes Karina P. Gomes Ruchita Shandilya Ruchita Shandilya Vaibhav B. Patel Vaibhav B. Patel |
| author_facet | Anshul S. Jadli Anshul S. Jadli Ananya Parasor Ananya Parasor Karina P. Gomes Karina P. Gomes Ruchita Shandilya Ruchita Shandilya Vaibhav B. Patel Vaibhav B. Patel |
| author_sort | Anshul S. Jadli |
| collection | DOAJ |
| description | Cardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recovery in CVD patients. Nevertheless, elusive and multifactorial pathophysiological mechanisms of CVD development perplexed researchers in identifying efficacious therapeutic interventions. Search for novel and effective strategies for diagnosis, prevention, and intervention for CVD has shifted research focus on extracellular vesicles (EVs) in recent years. By transporting molecular cargo from donor to recipient cells, EVs modulate gene expression and influence the phenotype of recipient cells, thus EVs prove to be an imperative component of intercellular signaling. Elucidation of the role of EVs in intercellular communications under physiological conditions implied the enormous potential of EVs in monitoring and treatment of CVD. The EVs secreted from the myriad of cells in the cardiovascular system such as cardiomyocytes, cardiac fibroblasts, cardiac progenitor cells, endothelial cells, inflammatory cells may facilitate the communication in physiological and pathological conditions. Understanding EVs-mediated cellular communication may delineate the mechanism of origin and progression of cardiovascular diseases. The current review summarizes exosome-mediated paracrine signaling leading to cardiovascular disease. The mechanistic role of exosomes in cardiovascular disease will provide novel avenues in designing diagnosis and therapeutic interventions. |
| first_indexed | 2024-12-14T06:59:34Z |
| format | Article |
| id | doaj.art-236635b768df498189eb94d788c86f61 |
| institution | Directory Open Access Journal |
| issn | 2297-055X |
| language | English |
| last_indexed | 2024-12-14T06:59:34Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj.art-236635b768df498189eb94d788c86f612022-12-21T23:12:28ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2021-11-01810.3389/fcvm.2021.767488767488Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-MessengerAnshul S. Jadli0Anshul S. Jadli1Ananya Parasor2Ananya Parasor3Karina P. Gomes4Karina P. Gomes5Ruchita Shandilya6Ruchita Shandilya7Vaibhav B. Patel8Vaibhav B. Patel9Department of Physiology and Pharmacology, Cumming School of Medicine, Calgary, AB, CanadaLibin Cardiovascular Institute, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Cumming School of Medicine, Calgary, AB, CanadaLibin Cardiovascular Institute, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Cumming School of Medicine, Calgary, AB, CanadaLibin Cardiovascular Institute, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Cumming School of Medicine, Calgary, AB, CanadaLibin Cardiovascular Institute, University of Calgary, Calgary, AB, CanadaDepartment of Physiology and Pharmacology, Cumming School of Medicine, Calgary, AB, CanadaLibin Cardiovascular Institute, University of Calgary, Calgary, AB, CanadaCardiovascular diseases (CVDs) represent a major global health problem, due to their continued high incidences and mortality. The last few decades have witnessed new advances in clinical research which led to increased survival and recovery in CVD patients. Nevertheless, elusive and multifactorial pathophysiological mechanisms of CVD development perplexed researchers in identifying efficacious therapeutic interventions. Search for novel and effective strategies for diagnosis, prevention, and intervention for CVD has shifted research focus on extracellular vesicles (EVs) in recent years. By transporting molecular cargo from donor to recipient cells, EVs modulate gene expression and influence the phenotype of recipient cells, thus EVs prove to be an imperative component of intercellular signaling. Elucidation of the role of EVs in intercellular communications under physiological conditions implied the enormous potential of EVs in monitoring and treatment of CVD. The EVs secreted from the myriad of cells in the cardiovascular system such as cardiomyocytes, cardiac fibroblasts, cardiac progenitor cells, endothelial cells, inflammatory cells may facilitate the communication in physiological and pathological conditions. Understanding EVs-mediated cellular communication may delineate the mechanism of origin and progression of cardiovascular diseases. The current review summarizes exosome-mediated paracrine signaling leading to cardiovascular disease. The mechanistic role of exosomes in cardiovascular disease will provide novel avenues in designing diagnosis and therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fcvm.2021.767488/fullextracellular vesiclesexosomescardiovascular diseaseheart failureatherosclerosis |
| spellingShingle | Anshul S. Jadli Anshul S. Jadli Ananya Parasor Ananya Parasor Karina P. Gomes Karina P. Gomes Ruchita Shandilya Ruchita Shandilya Vaibhav B. Patel Vaibhav B. Patel Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger Frontiers in Cardiovascular Medicine extracellular vesicles exosomes cardiovascular disease heart failure atherosclerosis |
| title | Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger |
| title_full | Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger |
| title_fullStr | Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger |
| title_full_unstemmed | Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger |
| title_short | Exosomes in Cardiovascular Diseases: Pathological Potential of Nano-Messenger |
| title_sort | exosomes in cardiovascular diseases pathological potential of nano messenger |
| topic | extracellular vesicles exosomes cardiovascular disease heart failure atherosclerosis |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2021.767488/full |
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