18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes
Abstract Background Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM. Purpose We evaluated 18F-FDG muscle uptake in patients with PM/DM c...
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| Format: | Article |
| Language: | English |
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SpringerOpen
2020-08-01
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| Series: | European Journal of Hybrid Imaging |
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| Online Access: | http://link.springer.com/article/10.1186/s41824-020-00084-w |
| _version_ | 1830373865983836160 |
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| author | Hanae Arai-Okuda Takashi Norikane Yuka Yamamoto Katsuya Mitamura Kengo Fujimoto Yasukage Takami Risa Wakiya Shusaku Nakashima Hiroaki Dobashi Yoshihiro Nishiyama |
| author_facet | Hanae Arai-Okuda Takashi Norikane Yuka Yamamoto Katsuya Mitamura Kengo Fujimoto Yasukage Takami Risa Wakiya Shusaku Nakashima Hiroaki Dobashi Yoshihiro Nishiyama |
| author_sort | Hanae Arai-Okuda |
| collection | DOAJ |
| description | Abstract Background Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM. Purpose We evaluated 18F-FDG muscle uptake in patients with PM/DM compared with non-muscular diseases and correlated the results with serum muscle enzymes. Methods A total of 28 patients with untreated PM/DM and 28 control patients with non-muscular diseases were examined with 18F-FDG PET/CT. 18F-FDG uptake was evaluated in 9 proximal skeletal muscle regions bilaterally. The uptake was scored as follows: 0 = less than that of the mediastinal blood vessels, 1 = greater than or equal to that of the mediastinal blood vessels, and 2 = greater than or equal to that of the liver. A score 1 or 2 was considered positive. The mean and maximum standardized uptake values (SUV) were calculated in each muscle and were averaged for all muscle regions. PET findings were correlated with serum muscle enzymes. Results 18F-FDG uptake was observed in 82% of patients with PM/DM and 7% of control patients. The number of positive regions, total score, mean SUVmean, and mean SUVmax in patients with PM/DM were significantly higher than those in the control patients (all P < 0.001). The total score of 2 was the best cut-off value that could discriminate patients with PM/DM from control patients. The total score, mean SUVmean, and mean SUVmax showed significant correlations with creatine kinase (P = 0.047, 0.002, 0.010, respectively) and aldolase (P = 0.036, 0.005, 0.038, respectively). Conclusion 18F-FDG PET/CT using visual and SUV methods demonstrated its usefulness by discriminating PM/DM from non-muscular diseases and correlating with serum muscle enzymes in patients with PM/DM. |
| first_indexed | 2024-12-20T07:26:23Z |
| format | Article |
| id | doaj.art-2366484297514c75b34de1c8cddc5c21 |
| institution | Directory Open Access Journal |
| issn | 2510-3636 |
| language | English |
| last_indexed | 2024-12-20T07:26:23Z |
| publishDate | 2020-08-01 |
| publisher | SpringerOpen |
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| series | European Journal of Hybrid Imaging |
| spelling | doaj.art-2366484297514c75b34de1c8cddc5c212022-12-21T19:48:31ZengSpringerOpenEuropean Journal of Hybrid Imaging2510-36362020-08-014111010.1186/s41824-020-00084-w18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymesHanae Arai-Okuda0Takashi Norikane1Yuka Yamamoto2Katsuya Mitamura3Kengo Fujimoto4Yasukage Takami5Risa Wakiya6Shusaku Nakashima7Hiroaki Dobashi8Yoshihiro Nishiyama9Department of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityDivision of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa UniversityDivision of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa UniversityDivision of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa UniversityDepartment of Radiology, Faculty of Medicine, Kagawa UniversityAbstract Background Muscle enzymes are the major noninvasive diagnostic parameters useful in polymyositis/dermatomyositis (PM/DM). Few studies have yet correlated findings on 18F-FDG PET with disease activity in patients with PM/DM. Purpose We evaluated 18F-FDG muscle uptake in patients with PM/DM compared with non-muscular diseases and correlated the results with serum muscle enzymes. Methods A total of 28 patients with untreated PM/DM and 28 control patients with non-muscular diseases were examined with 18F-FDG PET/CT. 18F-FDG uptake was evaluated in 9 proximal skeletal muscle regions bilaterally. The uptake was scored as follows: 0 = less than that of the mediastinal blood vessels, 1 = greater than or equal to that of the mediastinal blood vessels, and 2 = greater than or equal to that of the liver. A score 1 or 2 was considered positive. The mean and maximum standardized uptake values (SUV) were calculated in each muscle and were averaged for all muscle regions. PET findings were correlated with serum muscle enzymes. Results 18F-FDG uptake was observed in 82% of patients with PM/DM and 7% of control patients. The number of positive regions, total score, mean SUVmean, and mean SUVmax in patients with PM/DM were significantly higher than those in the control patients (all P < 0.001). The total score of 2 was the best cut-off value that could discriminate patients with PM/DM from control patients. The total score, mean SUVmean, and mean SUVmax showed significant correlations with creatine kinase (P = 0.047, 0.002, 0.010, respectively) and aldolase (P = 0.036, 0.005, 0.038, respectively). Conclusion 18F-FDG PET/CT using visual and SUV methods demonstrated its usefulness by discriminating PM/DM from non-muscular diseases and correlating with serum muscle enzymes in patients with PM/DM.http://link.springer.com/article/10.1186/s41824-020-00084-w18F-FDGPETPolymyositisDermatomyositis |
| spellingShingle | Hanae Arai-Okuda Takashi Norikane Yuka Yamamoto Katsuya Mitamura Kengo Fujimoto Yasukage Takami Risa Wakiya Shusaku Nakashima Hiroaki Dobashi Yoshihiro Nishiyama 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes European Journal of Hybrid Imaging 18F-FDG PET Polymyositis Dermatomyositis |
| title | 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes |
| title_full | 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes |
| title_fullStr | 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes |
| title_full_unstemmed | 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes |
| title_short | 18F-FDG PET/CT in patients with polymyositis/dermatomyositis: correlation with serum muscle enzymes |
| title_sort | 18f fdg pet ct in patients with polymyositis dermatomyositis correlation with serum muscle enzymes |
| topic | 18F-FDG PET Polymyositis Dermatomyositis |
| url | http://link.springer.com/article/10.1186/s41824-020-00084-w |
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