Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan
Several genetic variants have been identified that cause variation among different populations and even within individuals of a similar descent. This leads to interindividual variations in the optimal dose of the drug that is required to sustain the treatment efficiency. In this study, 56 single nuc...
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| Format: | Article |
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MDPI AG
2020-01-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/10/1/2 |
| _version_ | 1797758213345509376 |
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| author | Laith N. AL-Eitan Doaa M. Rababa’h Nancy M. Hakooz Mansour A. Alghamdi Rana B. Dajani |
| author_facet | Laith N. AL-Eitan Doaa M. Rababa’h Nancy M. Hakooz Mansour A. Alghamdi Rana B. Dajani |
| author_sort | Laith N. AL-Eitan |
| collection | DOAJ |
| description | Several genetic variants have been identified that cause variation among different populations and even within individuals of a similar descent. This leads to interindividual variations in the optimal dose of the drug that is required to sustain the treatment efficiency. In this study, 56 single nucleotide polymorphisms (SNPs) within several pharmacogenes were analyzed in 128 unrelated subjects from a genetically isolated group of Circassian people living in Jordan. We also compared these variant distributions to other ethnic groups that are available at two databases (Genome 1000 and eXAC). Our results revealed that the distribution of allele frequencies within genes among Circassians in Jordan showed similarities and disparities when compared to other populations. This study provides a powerful base for clinically relevant SNPs to enhance medical research and future pharmacogenomic studies. Rare variants detected in isolated populations can significantly guide to novel loci involved in the development of clinically relevant traits. |
| first_indexed | 2024-03-12T18:26:48Z |
| format | Article |
| id | doaj.art-2369a66cc8394b359aa3e4f340f71174 |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-12T18:26:48Z |
| publishDate | 2020-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-2369a66cc8394b359aa3e4f340f711742023-08-02T08:29:52ZengMDPI AGJournal of Personalized Medicine2075-44262020-01-01101210.3390/jpm10010002jpm10010002Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from JordanLaith N. AL-Eitan0Doaa M. Rababa’h1Nancy M. Hakooz2Mansour A. Alghamdi3Rana B. Dajani4Department of Applied Biological Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, JordanDepartment of Applied Biological Sciences, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, JordanDepartment of Biopharmaceutics and Clinical Pharmacy, School of Pharmacy, University of Jordan, Amman 11942, JordanCollege of Medicine, King Khalid University, Abha 61421, Saudi ArabiaDepartment of Biology and Biotechnology, Hashemite University, Zarqa 13133, JordanSeveral genetic variants have been identified that cause variation among different populations and even within individuals of a similar descent. This leads to interindividual variations in the optimal dose of the drug that is required to sustain the treatment efficiency. In this study, 56 single nucleotide polymorphisms (SNPs) within several pharmacogenes were analyzed in 128 unrelated subjects from a genetically isolated group of Circassian people living in Jordan. We also compared these variant distributions to other ethnic groups that are available at two databases (Genome 1000 and eXAC). Our results revealed that the distribution of allele frequencies within genes among Circassians in Jordan showed similarities and disparities when compared to other populations. This study provides a powerful base for clinically relevant SNPs to enhance medical research and future pharmacogenomic studies. Rare variants detected in isolated populations can significantly guide to novel loci involved in the development of clinically relevant traits.https://www.mdpi.com/2075-4426/10/1/2pharmacogenomicsvip polymorphismphase i enzymesphase ii enzymesmetabolizing |
| spellingShingle | Laith N. AL-Eitan Doaa M. Rababa’h Nancy M. Hakooz Mansour A. Alghamdi Rana B. Dajani Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan Journal of Personalized Medicine pharmacogenomics vip polymorphism phase i enzymes phase ii enzymes metabolizing |
| title | Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan |
| title_full | Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan |
| title_fullStr | Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan |
| title_full_unstemmed | Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan |
| title_short | Genetic Polymorphisms of Pharmacogenes among the Genetically Isolated Circassian Subpopulation from Jordan |
| title_sort | genetic polymorphisms of pharmacogenes among the genetically isolated circassian subpopulation from jordan |
| topic | pharmacogenomics vip polymorphism phase i enzymes phase ii enzymes metabolizing |
| url | https://www.mdpi.com/2075-4426/10/1/2 |
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