<i>BAP1</i> Malignant Pleural Mesothelioma Mutations in <i>Caenorhabditis elegans</i> Reveal Synthetic Lethality between <i>ubh-4</i>/<i>BAP1</i> and the Proteasome Subunit <i>rpn-9</i>/<i>PSMD13</i>

<i>BAP1</i> Malignant Pleural Mesothelioma Mutations in <i>Caenorhabditis elegans</i> Reveal Synthetic Lethality between <i>ubh-4</i>/<i>BAP1</i> and the Proteasome Subunit <i>rpn-9</i>/<i>PSMD13</i>

The deubiquitinase BAP1 (BRCA1-associated protein 1) is associated with <i>BAP1</i> tumor predisposition syndrome (TPDS). <i>BAP1</i> is a tumor suppressor gene whose alterations in cancer are commonly caused by gene mutations leading to protein loss of function. By CRISPR-Ca...

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Bibliographic Details
Main Authors: Carmen Martínez-Fernández, Sweta Jha, Elisabet Aliagas, Carina I. Holmberg, Ernest Nadal, Julián Cerón
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Cells
Subjects:
<i>C. elegans</i>
<i>ubh-4</i>
BAP1
<i>rpn-9</i>
PSMD13
Malignant Pleural Mesothelioma
Online Access:https://www.mdpi.com/2073-4409/12/6/929

Internet

https://www.mdpi.com/2073-4409/12/6/929

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