The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR)
Primary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment of aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone / direct reni...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publications
2015-12-01
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| Series: | Journal of the Renin-Angiotensin-Aldosterone System |
| Online Access: | https://doi.org/10.1177/1470320313519487 |
| _version_ | 1797282273709522944 |
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| author | Piotr Glinicki Wojciech Jeske Lucyna Bednarek-Papierska Aleksandra Kruszyńska Małgorzata Gietka-Czernel Elżbieta Rosłonowska Jadwiga Słowińska-Srzednicka Anna Kasperlik-Załuska Wojciech Zgliczyński |
| author_facet | Piotr Glinicki Wojciech Jeske Lucyna Bednarek-Papierska Aleksandra Kruszyńska Małgorzata Gietka-Czernel Elżbieta Rosłonowska Jadwiga Słowińska-Srzednicka Anna Kasperlik-Załuska Wojciech Zgliczyński |
| author_sort | Piotr Glinicki |
| collection | DOAJ |
| description | Primary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment of aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone / direct renin concentration ratio (ADRR) could be similarly useful for screening patients suspected of PA. The study included 62 patients with indication for evaluation of the renin-angiotensin-aldosterone system and 35 healthy volunteers. In all participants we measured concentrations of serum aldosterone, plasma direct renin, and PRA after a night’s rest and again after walking for two hours. The concentrations of aldosterone, direct renin, and PRA were measured by isotopic methods (radioimmunoassay (RIA) / immunoradiometric assay (IRMA)). Correlations of ARR with ADRR in the supine position were r = 0.9162, r 2 = 0.8165 ( p < 0.01); and in the up-right position were r = 0.7765, r 2 = 0.9153 ( p < 0.01). The cut-off values of ARR and ADRR ≥ 100 presented highest specificity (99%) for the diagnosis of PA; however, quite acceptable specificity and sensitivity (> 80% and 100%, respectively) appeared for the ratios ≥ 30. We suggest that for practical and economic reasons ARR can be replaced by ADRR. |
| first_indexed | 2024-03-07T17:10:28Z |
| format | Article |
| id | doaj.art-236b2a60bd2241abb4f169657fcaac6f |
| institution | Directory Open Access Journal |
| issn | 1470-3203 1752-8976 |
| language | English |
| last_indexed | 2024-03-07T17:10:28Z |
| publishDate | 2015-12-01 |
| publisher | SAGE Publications |
| record_format | Article |
| series | Journal of the Renin-Angiotensin-Aldosterone System |
| spelling | doaj.art-236b2a60bd2241abb4f169657fcaac6f2024-03-03T01:17:32ZengSAGE PublicationsJournal of the Renin-Angiotensin-Aldosterone System1470-32031752-89762015-12-011610.1177/1470320313519487The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR)Piotr GlinickiWojciech JeskeLucyna Bednarek-PapierskaAleksandra KruszyńskaMałgorzata Gietka-CzernelElżbieta RosłonowskaJadwiga Słowińska-SrzednickaAnna Kasperlik-ZałuskaWojciech ZgliczyńskiPrimary aldosteronism (PA) is estimated to occur in 5–12% of patients with hypertension. Assessment of aldosterone / plasma renin activity (PRA) ratio (ARR) has been used as a screening test in patients suspected of PA. Direct determination of renin (DRC) and calculation of aldosterone / direct renin concentration ratio (ADRR) could be similarly useful for screening patients suspected of PA. The study included 62 patients with indication for evaluation of the renin-angiotensin-aldosterone system and 35 healthy volunteers. In all participants we measured concentrations of serum aldosterone, plasma direct renin, and PRA after a night’s rest and again after walking for two hours. The concentrations of aldosterone, direct renin, and PRA were measured by isotopic methods (radioimmunoassay (RIA) / immunoradiometric assay (IRMA)). Correlations of ARR with ADRR in the supine position were r = 0.9162, r 2 = 0.8165 ( p < 0.01); and in the up-right position were r = 0.7765, r 2 = 0.9153 ( p < 0.01). The cut-off values of ARR and ADRR ≥ 100 presented highest specificity (99%) for the diagnosis of PA; however, quite acceptable specificity and sensitivity (> 80% and 100%, respectively) appeared for the ratios ≥ 30. We suggest that for practical and economic reasons ARR can be replaced by ADRR.https://doi.org/10.1177/1470320313519487 |
| spellingShingle | Piotr Glinicki Wojciech Jeske Lucyna Bednarek-Papierska Aleksandra Kruszyńska Małgorzata Gietka-Czernel Elżbieta Rosłonowska Jadwiga Słowińska-Srzednicka Anna Kasperlik-Załuska Wojciech Zgliczyński The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) Journal of the Renin-Angiotensin-Aldosterone System |
| title | The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
| title_full | The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
| title_fullStr | The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
| title_full_unstemmed | The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
| title_short | The ratios of aldosterone / plasma renin activity (ARR) versus aldosterone / direct renin concentration (ADRR) |
| title_sort | ratios of aldosterone plasma renin activity arr versus aldosterone direct renin concentration adrr |
| url | https://doi.org/10.1177/1470320313519487 |
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