Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition
<i>Quercus mongolica</i> (QM)—a member of the Fagaceae family—has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition...
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MDPI AG
2020-05-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/25/9/2154 |
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| author | Min Kim Jun Yin In Hyeok Hwang Dong Hui Park Eun Kyeong Lee Min Ji Kim Min Won Lee |
| author_facet | Min Kim Jun Yin In Hyeok Hwang Dong Hui Park Eun Kyeong Lee Min Ji Kim Min Won Lee |
| author_sort | Min Kim |
| collection | DOAJ |
| description | <i>Quercus mongolica</i> (QM)—a member of the Fagaceae family—has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5α-reductase type 1 inhibitory activities compared with the PC, dutasteride. |
| first_indexed | 2024-03-10T20:02:10Z |
| format | Article |
| id | doaj.art-236c9a6ebc9b4b148a09cc415861b36a |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T20:02:10Z |
| publishDate | 2020-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-236c9a6ebc9b4b148a09cc415861b36a2023-11-19T23:30:14ZengMDPI AGMolecules1420-30492020-05-01259215410.3390/molecules25092154Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase InhibitionMin Kim0Jun Yin1In Hyeok Hwang2Dong Hui Park3Eun Kyeong Lee4Min Ji Kim5Min Won Lee6Department of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, KoreaDepartment of Pharmacognosy and Natural product-derived Medicine, College of Pharmacy, Chung-Ang University, Seoul 156–756, Korea<i>Quercus mongolica</i> (QM)—a member of the Fagaceae family—has been used as traditional medicine in Korea, China and Mongolia as a treatment for inflammation of oral, genital or anal mucosa and for external inflammation of skin. To treat acne vulgaris (AV), we evaluated the inhibition of inflammatory cytokines (IL-6 and IL-8) of QM leaf extract (QML) and its main compound, pedunculagin (PD) in vitro and 5α-reductase inhibitory activity by western blotting. As results, QML and PD showed potent NO production inhibitory activity compared with the positive control (PC), NG-monomethyl-L-arginine (L-NMMA). QML and PD was also showed the decreases of IL-6 and IL-8 compared with the PC, EGCG and exhibited potent 5α-reductase type 1 inhibitory activities compared with the PC, dutasteride.https://www.mdpi.com/1420-3049/25/9/2154<i>Quercus mongolica</i>pedunculaginanti-acne vulgaris |
| spellingShingle | Min Kim Jun Yin In Hyeok Hwang Dong Hui Park Eun Kyeong Lee Min Ji Kim Min Won Lee Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition Molecules <i>Quercus mongolica</i> pedunculagin anti-acne vulgaris |
| title | Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition |
| title_full | Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition |
| title_fullStr | Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition |
| title_full_unstemmed | Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition |
| title_short | Anti-Acne Vulgaris Effects of Pedunculagin from the Leaves of <i>Quercus mongolica</i> by Anti-Inflammatory Activity and 5α-Reductase Inhibition |
| title_sort | anti acne vulgaris effects of pedunculagin from the leaves of i quercus mongolica i by anti inflammatory activity and 5α reductase inhibition |
| topic | <i>Quercus mongolica</i> pedunculagin anti-acne vulgaris |
| url | https://www.mdpi.com/1420-3049/25/9/2154 |
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