Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions
Generalized lymphatic anomaly (GLA) is an infrequent multiorgan disease characterized by the presence of abnormal proliferation of lymphatic vessels. The diagnosis requires histological confirmation, and the treatment is controversial. We are presenting a case of a 28-year-old male patient who was d...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Karger Publishers
2023-08-01
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| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/530897 |
| _version_ | 1797690702156529664 |
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| author | Greta Catani Federico Waisberg Diego Enrico Andrés Rodriguez Yanina Pflüger María Laura Galluzzo María del Valle Centeno Isabel Colmenero Mora Amat Lisandro Paganini Anna Frida García Herrmann Matías Chacón |
| author_facet | Greta Catani Federico Waisberg Diego Enrico Andrés Rodriguez Yanina Pflüger María Laura Galluzzo María del Valle Centeno Isabel Colmenero Mora Amat Lisandro Paganini Anna Frida García Herrmann Matías Chacón |
| author_sort | Greta Catani |
| collection | DOAJ |
| description | Generalized lymphatic anomaly (GLA) is an infrequent multiorgan disease characterized by the presence of abnormal proliferation of lymphatic vessels. The diagnosis requires histological confirmation, and the treatment is controversial. We are presenting a case of a 28-year-old male patient who was diagnosed with an extragonadal mediastinal nonseminomatous germ cell tumor. He underwent chemotherapy, and during this treatment, radiologic findings evidenced lytic lesions. Multiple biopsies were performed, which revealed the presence of abnormal lymphatic vessels, characteristic of GLA. There are different etiologies of osteolytic lesions, and on some occasions, they mimic a tumoral entity. The clinical suspicion of GLA is the first step in approaching the diagnosis, particularly in young adult patients. |
| first_indexed | 2024-03-12T02:03:59Z |
| format | Article |
| id | doaj.art-236ecbf4d97b472bb9a68ba7709526a9 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-12T02:03:59Z |
| publishDate | 2023-08-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-236ecbf4d97b472bb9a68ba7709526a92023-09-07T07:56:38ZengKarger PublishersCase Reports in Oncology1662-65752023-08-0116159760310.1159/000530897530897Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic LesionsGreta Catani0Federico Waisberg1https://orcid.org/0000-0003-4435-5068Diego Enrico2Andrés Rodriguez3https://orcid.org/0000-0002-0880-3153Yanina Pflüger4María Laura Galluzzo5https://orcid.org/0000-0001-8609-6856María del Valle Centeno6Isabel Colmenero7Mora Amat8Lisandro Paganini9https://orcid.org/0000-0002-8692-0347Anna Frida García Herrmann10Matías Chacón11Departament of Oncology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartament of Oncology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartament of Oncology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartament of Oncology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartament of Oncology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartment of Pediatric Pathology, Hospital Prof. Dr. Juan P. Garrahan, Buenos Aires, ArgentinaDepartment of Pediatric Pathology, Hospital Prof. Dr. Juan P. Garrahan, Buenos Aires, ArgentinaDepartment of Pediatric Pathology, Hospital Infantil Universitario Nino Jesús, Madrid, SpainDepartment of Oncology Pathology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartment of Radiology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartment of Radiology, Alexander Fleming Institute, Buenos Aires, ArgentinaDepartament of Oncology, Alexander Fleming Institute, Buenos Aires, ArgentinaGeneralized lymphatic anomaly (GLA) is an infrequent multiorgan disease characterized by the presence of abnormal proliferation of lymphatic vessels. The diagnosis requires histological confirmation, and the treatment is controversial. We are presenting a case of a 28-year-old male patient who was diagnosed with an extragonadal mediastinal nonseminomatous germ cell tumor. He underwent chemotherapy, and during this treatment, radiologic findings evidenced lytic lesions. Multiple biopsies were performed, which revealed the presence of abnormal lymphatic vessels, characteristic of GLA. There are different etiologies of osteolytic lesions, and on some occasions, they mimic a tumoral entity. The clinical suspicion of GLA is the first step in approaching the diagnosis, particularly in young adult patients.https://beta.karger.com/Article/FullText/530897generalized lymphatic anomalylymphatic malformationslytic lesion |
| spellingShingle | Greta Catani Federico Waisberg Diego Enrico Andrés Rodriguez Yanina Pflüger María Laura Galluzzo María del Valle Centeno Isabel Colmenero Mora Amat Lisandro Paganini Anna Frida García Herrmann Matías Chacón Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions Case Reports in Oncology generalized lymphatic anomaly lymphatic malformations lytic lesion |
| title | Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions |
| title_full | Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions |
| title_fullStr | Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions |
| title_full_unstemmed | Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions |
| title_short | Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions |
| title_sort | generalized lymphatic anomaly as a differential diagnosis of lytic lesions |
| topic | generalized lymphatic anomaly lymphatic malformations lytic lesion |
| url | https://beta.karger.com/Article/FullText/530897 |
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