Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice

Polaprezinc attenuates cyclophosphamide-induced cystitis and related bladder pain in mice

Cav3.2 T-type Ca2+ channels targeted by H2S, a gasotransmitter, participate in cyclophosphamide-induced cystitis and bladder pain. Given that zinc selectively inhibits Cav3.2 among T-channel isoforms and also exhibits antioxidant activity, we examined whether polaprezinc (zinc-l-carnosine), a medici...

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Bibliographic Details
Main Authors:	Masahiro Murakami-Nakayama, Maho Tsubota, Saki Hiruma, Fumiko Sekiguchi, Kenji Matsuyama, Takeshi Kimura, Masahiro Moriyama, Atsufumi Kawabata
Format:	Article
Language:	English
Published:	Elsevier 2015-02-01
Series:	Journal of Pharmacological Sciences
Subjects:	Polaprezinc Cyclophosphamide-induced cystitis Bladder pain T-type Ca2+ channel Antioxidant activity
Online Access:	http://www.sciencedirect.com/science/article/pii/S1347861315000079

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