Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats

Umbilical mesenchymal stem cell-derived exosomes promote spinal cord functional recovery through the miR-146b/TLR4 -mediated NF-κB p65 signaling pathway in rats

Spinal cord injury (SCI) is an incurable central nervous system impairment that lack of efficient treatment. Exosomes derived from mesenchymal stem cells (MSCs) are widely applied in disease treatment. This work aimed to determine the promising therapeutic effects of MSC-derived exosomal miRNA146b o...

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Bibliographic Details
Main Authors: Xiujuan Wang, Ying Yang, Wei Li, MingYuan Hao, YongSheng Xu
Format: Article
Language:English
Published: Elsevier 2023-09-01
Series:Biochemistry and Biophysics Reports
Subjects:
Spinal cord injury
Mesenchymal stem cell
Exosomes
miR-146b
Toll-like receptor 4
Online Access:http://www.sciencedirect.com/science/article/pii/S240558082300078X

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