Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression
Although mammals possess roughly the same number of protein-coding genes as worms, it is evident that the non-coding transcriptome content has become far broader and more sophisticated during evolution. Indeed, the vital regulatory importance of both short and long non-coding RNAs (lncRNAs) has been...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-09-01
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| Series: | Non-Coding RNA |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2311-553X/6/3/40 |
| _version_ | 1797553362882789376 |
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| author | Paola Briata Roberto Gherzi |
| author_facet | Paola Briata Roberto Gherzi |
| author_sort | Paola Briata |
| collection | DOAJ |
| description | Although mammals possess roughly the same number of protein-coding genes as worms, it is evident that the non-coding transcriptome content has become far broader and more sophisticated during evolution. Indeed, the vital regulatory importance of both short and long non-coding RNAs (lncRNAs) has been demonstrated during the last two decades. RNA binding proteins (RBPs) represent approximately 7.5% of all proteins and regulate the fate and function of a huge number of transcripts thus contributing to ensure cellular homeostasis. Transcriptomic and proteomic studies revealed that RBP-based complexes often include lncRNAs. This review will describe examples of how lncRNA-RBP networks can virtually control all the post-transcriptional events in the cell. |
| first_indexed | 2024-03-10T16:15:20Z |
| format | Article |
| id | doaj.art-237298bde564494fbc4bc1d6df411938 |
| institution | Directory Open Access Journal |
| issn | 2311-553X |
| language | English |
| last_indexed | 2024-03-10T16:15:20Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Non-Coding RNA |
| spelling | doaj.art-237298bde564494fbc4bc1d6df4119382023-11-20T14:06:36ZengMDPI AGNon-Coding RNA2311-553X2020-09-01634010.3390/ncrna6030040Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene ExpressionPaola Briata0Roberto Gherzi1Gene Expression Regulation Laboratory, Ospedale Policlinico San Martino IRCCS, 16132 Genova, ItalyGene Expression Regulation Laboratory, Ospedale Policlinico San Martino IRCCS, 16132 Genova, ItalyAlthough mammals possess roughly the same number of protein-coding genes as worms, it is evident that the non-coding transcriptome content has become far broader and more sophisticated during evolution. Indeed, the vital regulatory importance of both short and long non-coding RNAs (lncRNAs) has been demonstrated during the last two decades. RNA binding proteins (RBPs) represent approximately 7.5% of all proteins and regulate the fate and function of a huge number of transcripts thus contributing to ensure cellular homeostasis. Transcriptomic and proteomic studies revealed that RBP-based complexes often include lncRNAs. This review will describe examples of how lncRNA-RBP networks can virtually control all the post-transcriptional events in the cell.https://www.mdpi.com/2311-553X/6/3/40long non-coding RNA 1RNA binding protein 2post-transcriptional regulation |
| spellingShingle | Paola Briata Roberto Gherzi Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression Non-Coding RNA long non-coding RNA 1 RNA binding protein 2 post-transcriptional regulation |
| title | Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression |
| title_full | Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression |
| title_fullStr | Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression |
| title_full_unstemmed | Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression |
| title_short | Long Non-Coding RNA-Ribonucleoprotein Networks in the Post-Transcriptional Control of Gene Expression |
| title_sort | long non coding rna ribonucleoprotein networks in the post transcriptional control of gene expression |
| topic | long non-coding RNA 1 RNA binding protein 2 post-transcriptional regulation |
| url | https://www.mdpi.com/2311-553X/6/3/40 |
| work_keys_str_mv | AT paolabriata longnoncodingrnaribonucleoproteinnetworksintheposttranscriptionalcontrolofgeneexpression AT robertogherzi longnoncodingrnaribonucleoproteinnetworksintheposttranscriptionalcontrolofgeneexpression |