Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women
Non-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disease characterized by hepatic steatosis, inflammation, and fibrosis that seriously endangers global public health. Epidemiological studies have shown that the incidence of non-alcoholic fatty liver disease in postmenopausal wome...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2023.1237845/full |
| _version_ | 1827855693656358912 |
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| author | ChenLu Zhao JunHao Shi DongFang Shang Min Guo Cheng Zhou WenXia Zhao |
| author_facet | ChenLu Zhao JunHao Shi DongFang Shang Min Guo Cheng Zhou WenXia Zhao |
| author_sort | ChenLu Zhao |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disease characterized by hepatic steatosis, inflammation, and fibrosis that seriously endangers global public health. Epidemiological studies have shown that the incidence of non-alcoholic fatty liver disease in postmenopausal women has significantly increased. Studies have shown that estrogen deficiency is the main reason for this situation, and supplementing estrogen has become a new direction for preventing the occurrence of postmenopausal fatty liver. However, although classical estrogen replacement therapy can reduce the incidence of postmenopausal NAFLD, it has the risk of increasing stroke and cardiovascular diseases, so it is not suitable for the treatment of postmenopausal NAFLD. More and more recent studies have provided evidence that phytoestrogens are a promising method for the treatment of postmenopausal NAFLD. However, the mechanism of phytoestrogens in preventing and treating postmenopausal NAFLD is still unclear. This paper summarizes the clinical and basic research evidence of phytoestrogens and reviews the potential therapeutic effects of phytoestrogens in postmenopausal NAFLD from six angles: enhancing lipid metabolism in liver and adipose tissue, enhancing glucose metabolism, reducing oxidative stress, reducing the inflammatory response, regulating intestinal flora, and blocking liver fibrosis (Graphical Abstract). |
| first_indexed | 2024-03-12T11:54:58Z |
| format | Article |
| id | doaj.art-2372f2c6aaa64cbe89b5f06816f03f6d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-03-12T11:54:58Z |
| publishDate | 2023-08-01 |
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| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-2372f2c6aaa64cbe89b5f06816f03f6d2023-08-31T04:52:09ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-08-011410.3389/fphar.2023.12378451237845Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal womenChenLu Zhao0JunHao Shi1DongFang Shang2Min Guo3Cheng Zhou4WenXia Zhao5First Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaFirst Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaDepartment of Digestive Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaDepartment of Digestive Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaFirst Clinical Medical College, Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaDepartment of Digestive Diseases, The First Affiliated Hospital of Henan University of Traditional Chinese Medicine, Zhengzhou, ChinaNon-alcoholic fatty liver disease (NAFLD) is a progressive metabolic disease characterized by hepatic steatosis, inflammation, and fibrosis that seriously endangers global public health. Epidemiological studies have shown that the incidence of non-alcoholic fatty liver disease in postmenopausal women has significantly increased. Studies have shown that estrogen deficiency is the main reason for this situation, and supplementing estrogen has become a new direction for preventing the occurrence of postmenopausal fatty liver. However, although classical estrogen replacement therapy can reduce the incidence of postmenopausal NAFLD, it has the risk of increasing stroke and cardiovascular diseases, so it is not suitable for the treatment of postmenopausal NAFLD. More and more recent studies have provided evidence that phytoestrogens are a promising method for the treatment of postmenopausal NAFLD. However, the mechanism of phytoestrogens in preventing and treating postmenopausal NAFLD is still unclear. This paper summarizes the clinical and basic research evidence of phytoestrogens and reviews the potential therapeutic effects of phytoestrogens in postmenopausal NAFLD from six angles: enhancing lipid metabolism in liver and adipose tissue, enhancing glucose metabolism, reducing oxidative stress, reducing the inflammatory response, regulating intestinal flora, and blocking liver fibrosis (Graphical Abstract).https://www.frontiersin.org/articles/10.3389/fphar.2023.1237845/fullphytoestrogens(PEs)postmenopausal womennon-alcoholic fatty liver diseaselipid metabolismglucose metabolismoxidative stress |
| spellingShingle | ChenLu Zhao JunHao Shi DongFang Shang Min Guo Cheng Zhou WenXia Zhao Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women Frontiers in Pharmacology phytoestrogens(PEs) postmenopausal women non-alcoholic fatty liver disease lipid metabolism glucose metabolism oxidative stress |
| title | Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women |
| title_full | Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women |
| title_fullStr | Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women |
| title_full_unstemmed | Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women |
| title_short | Protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women |
| title_sort | protective effect of phytoestrogens on nonalcoholic fatty liver disease in postmenopausal women |
| topic | phytoestrogens(PEs) postmenopausal women non-alcoholic fatty liver disease lipid metabolism glucose metabolism oxidative stress |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2023.1237845/full |
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