Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis
Purpose: Thyroid nodules classified as indeterminate in previous fine-needle aspiration cytology often necessitate additional evaluation to determine their histology, while shear wave elastography (SWE) offers an alternative option in this regard. The objective of this study was to assess the diagno...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023078623 |
| _version_ | 1827780282557661184 |
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| author | Yuxuan Qiu Zhichao Xing Qianru Yang Yan Luo Buyun Ma |
| author_facet | Yuxuan Qiu Zhichao Xing Qianru Yang Yan Luo Buyun Ma |
| author_sort | Yuxuan Qiu |
| collection | DOAJ |
| description | Purpose: Thyroid nodules classified as indeterminate in previous fine-needle aspiration cytology often necessitate additional evaluation to determine their histology, while shear wave elastography (SWE) offers an alternative option in this regard. The objective of this study was to assess the diagnostic effectiveness of SWE in evaluating indeterminate nodules. Methods: The PubMed, EMBASE, and Web of Science databases were searched from 1st January 1970 to 1st March 2023. The studies were reviewed and the data was extracted by two separate reviewers. A Bayesian bivariate model was utilized to quantitatively synthesize the diagnostic accuracy and yield of the studies in R. Results: A total of seven studies, involving indeterminate thyroid nodules undergoing SWE were included, and the overall malignancy rate was 34.1% (307/900). The summarized estimates of sensitivity and specificity were 0.792 (95% credible interval [CI], 0.727–0.850) and 0.845 (95% CI, 0.797–0.887), respectively. The summarized estimate for the diagnostic odds ratio (DOR) was 17.8 (95% CI, 14.0–22.6). Summarized receiver operating characteristic (SROC) plots indicated a trade-off between sensitivity and specificity, and the estimate of AUC was 0.866 (95% CI, 0.834–0.895). The summary estimates for positive and negative likelihood ratios were 4.67 (95% CI, 3.98–5.85) and 0.26 (95% CI, 0.23–0.28), respectively. Conclusions: The overall accuracy of SWE remains satisfactory in indeterminate thyroid nodules. However, it should be noted that the available data are still extremely limited, and more studies or guidelines are required to provide further insights. |
| first_indexed | 2024-03-11T15:02:30Z |
| format | Article |
| id | doaj.art-2375d18c203547c7bd4dc7f26696f696 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T15:02:30Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-2375d18c203547c7bd4dc7f26696f6962023-10-30T06:06:54ZengElsevierHeliyon2405-84402023-10-01910e20654Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysisYuxuan Qiu0Zhichao Xing1Qianru Yang2Yan Luo3Buyun Ma4Department of Ultrasound, West China Hospital, Sichuan University, Chengdu, China; Department of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Thyroid & Parathyroid Surgery, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Ultrasound, West China Hospital, Sichuan University, Chengdu, China; Corresponding author. Department of Ultrasound, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, Sichuan Province, China.Purpose: Thyroid nodules classified as indeterminate in previous fine-needle aspiration cytology often necessitate additional evaluation to determine their histology, while shear wave elastography (SWE) offers an alternative option in this regard. The objective of this study was to assess the diagnostic effectiveness of SWE in evaluating indeterminate nodules. Methods: The PubMed, EMBASE, and Web of Science databases were searched from 1st January 1970 to 1st March 2023. The studies were reviewed and the data was extracted by two separate reviewers. A Bayesian bivariate model was utilized to quantitatively synthesize the diagnostic accuracy and yield of the studies in R. Results: A total of seven studies, involving indeterminate thyroid nodules undergoing SWE were included, and the overall malignancy rate was 34.1% (307/900). The summarized estimates of sensitivity and specificity were 0.792 (95% credible interval [CI], 0.727–0.850) and 0.845 (95% CI, 0.797–0.887), respectively. The summarized estimate for the diagnostic odds ratio (DOR) was 17.8 (95% CI, 14.0–22.6). Summarized receiver operating characteristic (SROC) plots indicated a trade-off between sensitivity and specificity, and the estimate of AUC was 0.866 (95% CI, 0.834–0.895). The summary estimates for positive and negative likelihood ratios were 4.67 (95% CI, 3.98–5.85) and 0.26 (95% CI, 0.23–0.28), respectively. Conclusions: The overall accuracy of SWE remains satisfactory in indeterminate thyroid nodules. However, it should be noted that the available data are still extremely limited, and more studies or guidelines are required to provide further insights.http://www.sciencedirect.com/science/article/pii/S2405844023078623Thyroid noduleElasticity imaging techniquesCytological techniquesMeta-analysis |
| spellingShingle | Yuxuan Qiu Zhichao Xing Qianru Yang Yan Luo Buyun Ma Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis Heliyon Thyroid nodule Elasticity imaging techniques Cytological techniques Meta-analysis |
| title | Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis |
| title_full | Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis |
| title_fullStr | Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis |
| title_full_unstemmed | Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis |
| title_short | Diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology: A systematic review and meta-analysis |
| title_sort | diagnostic performance of shear wave elastography in thyroid nodules with indeterminate cytology a systematic review and meta analysis |
| topic | Thyroid nodule Elasticity imaging techniques Cytological techniques Meta-analysis |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023078623 |
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