Hippocampal volume changes across developmental periods in female migraineurs
Brain-related plasticity can occur at a significant rate varying on the developmental period. Adolescence in particular has been identified as a period of growth and change across the structure and function of the nervous system. Notably, research has identified migraines as common in both pediatric...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-08-01
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| Series: | Neurobiology of Pain |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452073X23000247 |
| _version_ | 1797405354478272512 |
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| author | Sophie L. Wilcox Sarah Nelson Allison Ludwick Andrew M. Youssef Alyssa Lebel Lino Beccera Rami Burstein David Borsook |
| author_facet | Sophie L. Wilcox Sarah Nelson Allison Ludwick Andrew M. Youssef Alyssa Lebel Lino Beccera Rami Burstein David Borsook |
| author_sort | Sophie L. Wilcox |
| collection | DOAJ |
| description | Brain-related plasticity can occur at a significant rate varying on the developmental period. Adolescence in particular has been identified as a period of growth and change across the structure and function of the nervous system. Notably, research has identified migraines as common in both pediatric and adult populations, but evidence suggests that the phenotype for migraines may differ in these cohorts due to the unique needs of each developmental period. Accordingly, primary aims of this study were to define hippocampal structure in females (7–27 years of age) with and without migraine, and to determine whether this differs across developmental stages (i.e., childhood, adolescence, and young adulthood). Hippocampal volume was quantified based on high-resolution structural MRI using FMRIB's Integrated Registration and Segmentation Tool. Results indicated that migraine and age may have an interactional relationship with hippocampal volume, such that, while hippocampal volumes were lower in female migraineurs (compared to age-matched controls) during childhood and adolescence, this contrast differed during young adulthood whereby hippocampal volumes were higher in migraineurs (compared to age-matched controls). Subsequent vertex analysis localized this interaction effect in hippocampal volume to displacement of the anterior hippocampus. The transition of hippocampal volume during adolescent development in migraineurs suggests that hippocampal plasticity may dynamically reflect components of migraine that change over the lifespan, exerting possible altered responsivity to stress related to migraine attacks thus having physiological expression and psychosocial impact. |
| first_indexed | 2024-03-09T03:08:45Z |
| format | Article |
| id | doaj.art-2375f901bcfd473c8561ea8b3b4abd6f |
| institution | Directory Open Access Journal |
| issn | 2452-073X |
| language | English |
| last_indexed | 2024-03-09T03:08:45Z |
| publishDate | 2023-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Neurobiology of Pain |
| spelling | doaj.art-2375f901bcfd473c8561ea8b3b4abd6f2023-12-04T05:23:44ZengElsevierNeurobiology of Pain2452-073X2023-08-0114100137Hippocampal volume changes across developmental periods in female migraineursSophie L. Wilcox0Sarah Nelson1Allison Ludwick2Andrew M. Youssef3Alyssa Lebel4Lino Beccera5Rami Burstein6David Borsook7Center for Pain and the Brain, Harvard Medical School, Boston, MA, USADepartment of Psychiatry, Boston Children’s Hospital, Harvard Medical School, Boston, MA, USA; Corresponding author.Center for Pain and the Brain, Harvard Medical School, Boston, MA, USADepartment of Anatomy and Histology, The University of Sydney, Sydney, NSW, AustraliaCenter for Pain and the Brain, Harvard Medical School, Boston, MA, USA; Pediatric Headache Program, Boston Children's Hospital, Waltham, MA, USACenter for Pain and the Brain, Harvard Medical School, Boston, MA, USA; Invicro, Boston, MA, USAAnesthesia and Critical Care, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USADepartment of Psychiatry and Department of Radiology, Massachusetts General Hospital, Boston, MA, USABrain-related plasticity can occur at a significant rate varying on the developmental period. Adolescence in particular has been identified as a period of growth and change across the structure and function of the nervous system. Notably, research has identified migraines as common in both pediatric and adult populations, but evidence suggests that the phenotype for migraines may differ in these cohorts due to the unique needs of each developmental period. Accordingly, primary aims of this study were to define hippocampal structure in females (7–27 years of age) with and without migraine, and to determine whether this differs across developmental stages (i.e., childhood, adolescence, and young adulthood). Hippocampal volume was quantified based on high-resolution structural MRI using FMRIB's Integrated Registration and Segmentation Tool. Results indicated that migraine and age may have an interactional relationship with hippocampal volume, such that, while hippocampal volumes were lower in female migraineurs (compared to age-matched controls) during childhood and adolescence, this contrast differed during young adulthood whereby hippocampal volumes were higher in migraineurs (compared to age-matched controls). Subsequent vertex analysis localized this interaction effect in hippocampal volume to displacement of the anterior hippocampus. The transition of hippocampal volume during adolescent development in migraineurs suggests that hippocampal plasticity may dynamically reflect components of migraine that change over the lifespan, exerting possible altered responsivity to stress related to migraine attacks thus having physiological expression and psychosocial impact.http://www.sciencedirect.com/science/article/pii/S2452073X23000247HeadacheMigraineBrainDevelopmentStress |
| spellingShingle | Sophie L. Wilcox Sarah Nelson Allison Ludwick Andrew M. Youssef Alyssa Lebel Lino Beccera Rami Burstein David Borsook Hippocampal volume changes across developmental periods in female migraineurs Neurobiology of Pain Headache Migraine Brain Development Stress |
| title | Hippocampal volume changes across developmental periods in female migraineurs |
| title_full | Hippocampal volume changes across developmental periods in female migraineurs |
| title_fullStr | Hippocampal volume changes across developmental periods in female migraineurs |
| title_full_unstemmed | Hippocampal volume changes across developmental periods in female migraineurs |
| title_short | Hippocampal volume changes across developmental periods in female migraineurs |
| title_sort | hippocampal volume changes across developmental periods in female migraineurs |
| topic | Headache Migraine Brain Development Stress |
| url | http://www.sciencedirect.com/science/article/pii/S2452073X23000247 |
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