Juvenile idiopathic arthritis – classification and methods of treatment
Introduction Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of unknown etiology that affect children. According to the definition of JIA, the disease begins before the age of 16 and lasts more than 6 weeks. The International League of Associations for Rheumatology...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Kazimierz Wielki University
2023-04-01
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| Series: | Journal of Education, Health and Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/JEHS/article/view/43209 |
| _version_ | 1797846271329828864 |
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| author | Weronika Pawłocik Laura Wojtala Weronika Pawlak Julia Szymańska Agnieszka Możdżyńska Lena Musiał Ewa Grabowska Kamil Kapłon Katarzyna Pacek Izabela Kamińska |
| author_facet | Weronika Pawłocik Laura Wojtala Weronika Pawlak Julia Szymańska Agnieszka Możdżyńska Lena Musiał Ewa Grabowska Kamil Kapłon Katarzyna Pacek Izabela Kamińska |
| author_sort | Weronika Pawłocik |
| collection | DOAJ |
| description |
Introduction Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of unknown etiology that affect children. According to the definition of JIA, the disease begins before the age of 16 and lasts more than 6 weeks. The International League of Associations for Rheumatology (ILAR) has divided juvenile idiopathic arthritis into seven categories: systemic, oligoarticular, polyarticular RF (-), polyarticular RF (+), psoriatic, enthesitis-related and undifferentiated arthritis. Purpose The aim of this review is to present the classification, etiopathogenesis, diagnosis, treatment and complications of juvenile idiopathic arthritis. Methods Literature searches in PubMed, Google Scholarship, and open source books were used to gather information. Results Complex interactions between cells of the immune system are responsible for the pathophysiology of JIA and indicate the need to divide the disease into clinical subtypes, the heterogeneity of which requires different therapeutic actions. There are many groups of drugs with different mechanisms of action used in the treatment of JIA, including: T lymphocyte inhibitors, anti-TNFα, JAK inhibitors, IL-1 and IL-6 blockers. Despite the great progress and the commitment of scientists, there is still no treatment strategy to completely stop the development of the disease. Conclusions Scientific research conducted around the world has led to the recognition of numerous pathways leading to the formation of the inflammatory process and the symptoms of JIA. Knowledge of these mechanisms allows scientists to conduct research on further drugs, the aim of which is to find a treatment strategy that prevents permanent joint damage, improves treatment results, and enables sustainable remission. It is necessary to expand knowledge about the pathways responsible for the formation of the inflammatory process, the interruption of which would allow complete inhibition of the development of the disease.
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| first_indexed | 2024-04-09T17:52:15Z |
| format | Article |
| id | doaj.art-237609dc70044b538a23df96b9eb2326 |
| institution | Directory Open Access Journal |
| issn | 2391-8306 |
| language | English |
| last_indexed | 2024-04-09T17:52:15Z |
| publishDate | 2023-04-01 |
| publisher | Kazimierz Wielki University |
| record_format | Article |
| series | Journal of Education, Health and Sport |
| spelling | doaj.art-237609dc70044b538a23df96b9eb23262023-04-15T10:45:20ZengKazimierz Wielki UniversityJournal of Education, Health and Sport2391-83062023-04-0118110.12775/JEHS.2023.18.01.009Juvenile idiopathic arthritis – classification and methods of treatmentWeronika Pawłocik0Laura Wojtala1Weronika Pawlak2Julia Szymańska3Agnieszka Możdżyńska4Lena Musiał5Ewa Grabowska6Kamil Kapłon7Katarzyna Pacek8Izabela Kamińska 9Uniwersytet Medyczny im. Karola Marcinkowskiego w PoznaniuUniwersytecki Szpital Kliniczny w Poznaniu, ul. Przybyszewskiego 49, 60-355 Poznań,Samodzielny Publiczny Zakład Opieki Zdrowotnej Ministerstwa Spraw Wewnętrznych i Administracji w Poznaniu im. prof. Ludwika Bierkowskiego, ul.Dojazd 34, 60-631 PoznańSzpital Miejski im. Franciszka Raszei ul. Mickiewicza 2, 60-834 Poznań,Szpital Średzki Serca Jezusowego Sp. z o.o. ul. Żwirki i Wigury 10, 63-000 Środa WielkopolskaSzpital Średzki Serca Jezusowego Sp. z o.o. ul. Żwirki i Wigury 10, 63-000 Środa WielkopolskaNowodworskie Centrum Medyczne ul. Miodowa 2, 05-100 Nowy Dwór MazowieckiUniwersytecki Szpital Kliniczny w Poznaniu ul. Przybyszewskiego 49, 60-355 PoznańCentralny Szpital Kliniczny MSWiA, ul. Wołoska 137, 02-507 WarszawaSzpital Czerniakowski sp. z o. o., ul. Stępińska 19/25, 00-739 Warszawa Introduction Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease of unknown etiology that affect children. According to the definition of JIA, the disease begins before the age of 16 and lasts more than 6 weeks. The International League of Associations for Rheumatology (ILAR) has divided juvenile idiopathic arthritis into seven categories: systemic, oligoarticular, polyarticular RF (-), polyarticular RF (+), psoriatic, enthesitis-related and undifferentiated arthritis. Purpose The aim of this review is to present the classification, etiopathogenesis, diagnosis, treatment and complications of juvenile idiopathic arthritis. Methods Literature searches in PubMed, Google Scholarship, and open source books were used to gather information. Results Complex interactions between cells of the immune system are responsible for the pathophysiology of JIA and indicate the need to divide the disease into clinical subtypes, the heterogeneity of which requires different therapeutic actions. There are many groups of drugs with different mechanisms of action used in the treatment of JIA, including: T lymphocyte inhibitors, anti-TNFα, JAK inhibitors, IL-1 and IL-6 blockers. Despite the great progress and the commitment of scientists, there is still no treatment strategy to completely stop the development of the disease. Conclusions Scientific research conducted around the world has led to the recognition of numerous pathways leading to the formation of the inflammatory process and the symptoms of JIA. Knowledge of these mechanisms allows scientists to conduct research on further drugs, the aim of which is to find a treatment strategy that prevents permanent joint damage, improves treatment results, and enables sustainable remission. It is necessary to expand knowledge about the pathways responsible for the formation of the inflammatory process, the interruption of which would allow complete inhibition of the development of the disease. https://apcz.umk.pl/JEHS/article/view/43209Juvenile idiopathic arthritisarthritispediatricbiological treatment |
| spellingShingle | Weronika Pawłocik Laura Wojtala Weronika Pawlak Julia Szymańska Agnieszka Możdżyńska Lena Musiał Ewa Grabowska Kamil Kapłon Katarzyna Pacek Izabela Kamińska Juvenile idiopathic arthritis – classification and methods of treatment Journal of Education, Health and Sport Juvenile idiopathic arthritis arthritis pediatric biological treatment |
| title | Juvenile idiopathic arthritis – classification and methods of treatment |
| title_full | Juvenile idiopathic arthritis – classification and methods of treatment |
| title_fullStr | Juvenile idiopathic arthritis – classification and methods of treatment |
| title_full_unstemmed | Juvenile idiopathic arthritis – classification and methods of treatment |
| title_short | Juvenile idiopathic arthritis – classification and methods of treatment |
| title_sort | juvenile idiopathic arthritis classification and methods of treatment |
| topic | Juvenile idiopathic arthritis arthritis pediatric biological treatment |
| url | https://apcz.umk.pl/JEHS/article/view/43209 |
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