Synchrony of the first division as an index of the blastocyst formation rate during embryonic development
Abstract Purpose To devise an uninvasive selection system for human embryos with high developmental potential after a single oocyte retrieval cycle by comparing the in vitro and in vivo effectiveness of first division synchrony against subsequent embryonic developmental stages. Methods The effects o...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Reproductive Medicine and Biology |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/rmb2.12070 |
| _version_ | 1818127650771697664 |
|---|---|
| author | Yamato Mizobe Makoto Tokunaga Naoto Oya Reiko Iwakiri Naomi Yoshida Yumi Sato Nanase Onoue Yuji Ezono |
| author_facet | Yamato Mizobe Makoto Tokunaga Naoto Oya Reiko Iwakiri Naomi Yoshida Yumi Sato Nanase Onoue Yuji Ezono |
| author_sort | Yamato Mizobe |
| collection | DOAJ |
| description | Abstract Purpose To devise an uninvasive selection system for human embryos with high developmental potential after a single oocyte retrieval cycle by comparing the in vitro and in vivo effectiveness of first division synchrony against subsequent embryonic developmental stages. Methods The effects of using assisted reproductive technology on 948 embryos that were produced in 137 cycles were examined by dividing the embryos into “early cleavage” (first division within 25.90 hours) and “late cleavage” (first division at or after 25.90 hours) groups and comparing the blastocysts and good‐quality blastocyst formation rates between the two groups. These two groups were each divided further into “high synchrony” (first division synchrony within 3.96 hours) and “low synchrony” (first division synchrony at or after 3.96 hours) groups. The blastocysts, good‐quality blastocyst formation rates, and pregnancy rates were compared among these four groups. Results Both the blastocysts and good‐quality blastocyst formation rates were significantly higher in the early‐cleavage groups than in the late‐cleavage groups. The blastocyst formation rate of the latter was also significantly increased in the high‐synchrony, compared with the low‐synchrony, group. Conclusion First division synchrony in a single oocyte retrieval cycle could be a useful assessment of the blastocyst formation rate that enables the selection of viable embryos at an early stage of culture. |
| first_indexed | 2024-12-11T07:20:44Z |
| format | Article |
| id | doaj.art-23761534aea8481b83a1e4ef7fa0893d |
| institution | Directory Open Access Journal |
| issn | 1445-5781 1447-0578 |
| language | English |
| last_indexed | 2024-12-11T07:20:44Z |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Reproductive Medicine and Biology |
| spelling | doaj.art-23761534aea8481b83a1e4ef7fa0893d2022-12-22T01:16:05ZengWileyReproductive Medicine and Biology1445-57811447-05782018-01-01171647010.1002/rmb2.12070Synchrony of the first division as an index of the blastocyst formation rate during embryonic developmentYamato Mizobe0Makoto Tokunaga1Naoto Oya2Reiko Iwakiri3Naomi Yoshida4Yumi Sato5Nanase Onoue6Yuji Ezono7Aiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAiiku Ladies Clinic Kagoshima JapanAbstract Purpose To devise an uninvasive selection system for human embryos with high developmental potential after a single oocyte retrieval cycle by comparing the in vitro and in vivo effectiveness of first division synchrony against subsequent embryonic developmental stages. Methods The effects of using assisted reproductive technology on 948 embryos that were produced in 137 cycles were examined by dividing the embryos into “early cleavage” (first division within 25.90 hours) and “late cleavage” (first division at or after 25.90 hours) groups and comparing the blastocysts and good‐quality blastocyst formation rates between the two groups. These two groups were each divided further into “high synchrony” (first division synchrony within 3.96 hours) and “low synchrony” (first division synchrony at or after 3.96 hours) groups. The blastocysts, good‐quality blastocyst formation rates, and pregnancy rates were compared among these four groups. Results Both the blastocysts and good‐quality blastocyst formation rates were significantly higher in the early‐cleavage groups than in the late‐cleavage groups. The blastocyst formation rate of the latter was also significantly increased in the high‐synchrony, compared with the low‐synchrony, group. Conclusion First division synchrony in a single oocyte retrieval cycle could be a useful assessment of the blastocyst formation rate that enables the selection of viable embryos at an early stage of culture.https://doi.org/10.1002/rmb2.12070blastocystembryofirst divisionsynchronytime‐lapse incubator |
| spellingShingle | Yamato Mizobe Makoto Tokunaga Naoto Oya Reiko Iwakiri Naomi Yoshida Yumi Sato Nanase Onoue Yuji Ezono Synchrony of the first division as an index of the blastocyst formation rate during embryonic development Reproductive Medicine and Biology blastocyst embryo first division synchrony time‐lapse incubator |
| title | Synchrony of the first division as an index of the blastocyst formation rate during embryonic development |
| title_full | Synchrony of the first division as an index of the blastocyst formation rate during embryonic development |
| title_fullStr | Synchrony of the first division as an index of the blastocyst formation rate during embryonic development |
| title_full_unstemmed | Synchrony of the first division as an index of the blastocyst formation rate during embryonic development |
| title_short | Synchrony of the first division as an index of the blastocyst formation rate during embryonic development |
| title_sort | synchrony of the first division as an index of the blastocyst formation rate during embryonic development |
| topic | blastocyst embryo first division synchrony time‐lapse incubator |
| url | https://doi.org/10.1002/rmb2.12070 |
| work_keys_str_mv | AT yamatomizobe synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT makototokunaga synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT naotooya synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT reikoiwakiri synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT naomiyoshida synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT yumisato synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT nanaseonoue synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment AT yujiezono synchronyofthefirstdivisionasanindexoftheblastocystformationrateduringembryonicdevelopment |