The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers
Herpes labialis is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums, or the skin around the mouth. Although there is no successful treatment available, the local use of compounds with effective an...
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2017-03-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/596 |
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| author | Tagreed S. Altaei Intesar T. Numan Saad A.Hussain Nazar G. Al-Talabani |
| author_facet | Tagreed S. Altaei Intesar T. Numan Saad A.Hussain Nazar G. Al-Talabani |
| author_sort | Tagreed S. Altaei |
| collection | DOAJ |
| description | Herpes labialis is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums, or the skin around the mouth. Although there is no successful treatment available, the local use of compounds with effective anti-inflammatory and cytoprotective effects may be of value in this respect. This project was designed to evaluate clinically the local use of silymarin, a group of flavonoids with powerful antioxidant, anti-inflammatory and cytoprotective activity, in the treatment of herpes simplex ulcer. Fifty three patients with herpes labialis ulcers (HLU) were enrolled in this randomized, single blinded, placebo controlled clinical study, and they were allocated into 4 groups, treated with 1%, 3% and 5% silymarin paste and placebo formula respectively. Patient's responses to treatment were followed by clinical evaluation of healing time, size of the ulcers and pain sensation, in addition to evaluating biochemical and immunological markers of the oxidative stress and inflammatory response. HLU patients showed dose dependent improvement in the healing time, pain score and size of ulcer as a result of treatment with various concentrations (1%, 3% and 5%) of silymarin paste, associated with improvement in the oxidative stress state and immunological parameters. In conclusion, silymarin can be used locally as paste formula for the treatment of HLU, an effect which may be attributed to its antioxidant, anti-inflammatory and cytoprotective properties.
Keywords: Herpes labialis, ulcers, silymarin |
| first_indexed | 2024-12-18T23:08:00Z |
| format | Article |
| id | doaj.art-2376789f6e244f79a7ef98a77d49cb0c |
| institution | Directory Open Access Journal |
| issn | 2521-3512 1683-3597 |
| language | English |
| last_indexed | 2024-12-18T23:08:00Z |
| publishDate | 2017-03-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj.art-2376789f6e244f79a7ef98a77d49cb0c2022-12-21T20:48:25ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972017-03-0116110.31351/vol16iss1pp39-46The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis UlcersTagreed S. AltaeiIntesar T. NumanSaad A.HussainNazar G. Al-TalabaniHerpes labialis is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums, or the skin around the mouth. Although there is no successful treatment available, the local use of compounds with effective anti-inflammatory and cytoprotective effects may be of value in this respect. This project was designed to evaluate clinically the local use of silymarin, a group of flavonoids with powerful antioxidant, anti-inflammatory and cytoprotective activity, in the treatment of herpes simplex ulcer. Fifty three patients with herpes labialis ulcers (HLU) were enrolled in this randomized, single blinded, placebo controlled clinical study, and they were allocated into 4 groups, treated with 1%, 3% and 5% silymarin paste and placebo formula respectively. Patient's responses to treatment were followed by clinical evaluation of healing time, size of the ulcers and pain sensation, in addition to evaluating biochemical and immunological markers of the oxidative stress and inflammatory response. HLU patients showed dose dependent improvement in the healing time, pain score and size of ulcer as a result of treatment with various concentrations (1%, 3% and 5%) of silymarin paste, associated with improvement in the oxidative stress state and immunological parameters. In conclusion, silymarin can be used locally as paste formula for the treatment of HLU, an effect which may be attributed to its antioxidant, anti-inflammatory and cytoprotective properties. Keywords: Herpes labialis, ulcers, silymarinhttps://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/596 |
| spellingShingle | Tagreed S. Altaei Intesar T. Numan Saad A.Hussain Nazar G. Al-Talabani The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers Iraqi Journal of Pharmaceutical Sciences |
| title | The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers |
| title_full | The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers |
| title_fullStr | The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers |
| title_full_unstemmed | The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers |
| title_short | The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers |
| title_sort | efficacy of topically applied silymarin in the treatment of herpes labialis ulcers |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/596 |
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