Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor?
Abstract Background Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screening might later develop signs of androgen excess. The aim of this study...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2018-01-01
|
| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13052-018-0444-6 |
| _version_ | 1818596806565560320 |
|---|---|
| author | Paolo Cavarzere Margherita Mauro Monica Vincenzi Silvana Lauriola Francesca Teofoli Rossella Gaudino Diego Alberto Ramaroli Rocco Micciolo Marta Camilot Franco Antoniazzi |
| author_facet | Paolo Cavarzere Margherita Mauro Monica Vincenzi Silvana Lauriola Francesca Teofoli Rossella Gaudino Diego Alberto Ramaroli Rocco Micciolo Marta Camilot Franco Antoniazzi |
| author_sort | Paolo Cavarzere |
| collection | DOAJ |
| description | Abstract Background Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screening might later develop signs of androgen excess. The aim of this study is to verify whether a slightly elevated 17-OHP at newborn screening is a predictive factor for premature pubarche. Methods We evaluated all infants born between 2001 and 2014 with premature pubarche. In case of increased bone age, they were submitted to functional tests to find out the cause of their symptoms. Their 17-OHP values at newborn screening for CAH were reconsidered. Results We identified 330 patients (269 females, 61 males) with premature pubarche. All these children had a normal 17-OHP at newborn screening with the exception of a child, born preterm and not affected by CAH. Conclusions An elevated 17-OHP at newborn screening is not a predictive factor for premature pubarche. A likely cause of increased 17-OHP level at screening is an immaturity of adrenal gland or a neonatal stress. Therefore a strict follow up of these neonates during childhood is not necessary. |
| first_indexed | 2024-12-16T11:37:46Z |
| format | Article |
| id | doaj.art-2376c08fd05c4c77a0dfe1d79c577e52 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-16T11:37:46Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-2376c08fd05c4c77a0dfe1d79c577e522022-12-21T22:33:01ZengBMCItalian Journal of Pediatrics1824-72882018-01-014411610.1186/s13052-018-0444-6Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor?Paolo Cavarzere0Margherita Mauro1Monica Vincenzi2Silvana Lauriola3Francesca Teofoli4Rossella Gaudino5Diego Alberto Ramaroli6Rocco Micciolo7Marta Camilot8Franco Antoniazzi9Pediatric Division, Department of Pediatrics, University Hospital of VeronaPediatric Division, Department of Pediatrics, University Hospital of VeronaPediatric Division, Department of Pediatrics, University Hospital of VeronaDepartment of Pediatrics, Neonatal Intensive Care Unit, University Hospital of VeronaPediatric Division, Department of Pediatrics, University Hospital of VeronaPediatric Division, Department of Pediatrics, University Hospital of VeronaPediatric Division, Department of Pediatrics, University Hospital of VeronaDepartment of Psychology and Cognitive Sciences, University of TrentoPediatric Division, Department of Pediatrics, University Hospital of VeronaPediatric Division, Department of Pediatrics, University Hospital of VeronaAbstract Background Neonatal screening for 21 hydroxylase deficiency is designed to detect classical form of congenital adrenal hyperplasia (CAH). It is still unclear whether newborns who result false positives at neonatal screening might later develop signs of androgen excess. The aim of this study is to verify whether a slightly elevated 17-OHP at newborn screening is a predictive factor for premature pubarche. Methods We evaluated all infants born between 2001 and 2014 with premature pubarche. In case of increased bone age, they were submitted to functional tests to find out the cause of their symptoms. Their 17-OHP values at newborn screening for CAH were reconsidered. Results We identified 330 patients (269 females, 61 males) with premature pubarche. All these children had a normal 17-OHP at newborn screening with the exception of a child, born preterm and not affected by CAH. Conclusions An elevated 17-OHP at newborn screening is not a predictive factor for premature pubarche. A likely cause of increased 17-OHP level at screening is an immaturity of adrenal gland or a neonatal stress. Therefore a strict follow up of these neonates during childhood is not necessary.http://link.springer.com/article/10.1186/s13052-018-0444-6Premature pubarche17-OhpNewborn screeningCongenital adrenal hyperplasia |
| spellingShingle | Paolo Cavarzere Margherita Mauro Monica Vincenzi Silvana Lauriola Francesca Teofoli Rossella Gaudino Diego Alberto Ramaroli Rocco Micciolo Marta Camilot Franco Antoniazzi Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor? Italian Journal of Pediatrics Premature pubarche 17-Ohp Newborn screening Congenital adrenal hyperplasia |
| title | Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor? |
| title_full | Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor? |
| title_fullStr | Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor? |
| title_full_unstemmed | Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor? |
| title_short | Children with premature pubarche: is an alterated neonatal 17-Ohp screening test a predictive factor? |
| title_sort | children with premature pubarche is an alterated neonatal 17 ohp screening test a predictive factor |
| topic | Premature pubarche 17-Ohp Newborn screening Congenital adrenal hyperplasia |
| url | http://link.springer.com/article/10.1186/s13052-018-0444-6 |
| work_keys_str_mv | AT paolocavarzere childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT margheritamauro childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT monicavincenzi childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT silvanalauriola childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT francescateofoli childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT rossellagaudino childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT diegoalbertoramaroli childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT roccomicciolo childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT martacamilot childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor AT francoantoniazzi childrenwithprematurepubarcheisanalteratedneonatal17ohpscreeningtestapredictivefactor |