Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels

Disordered GPR43/NLRP3 expression in peripheral leukocytes of patients with atrial fibrillation is associated with intestinal short chain fatty acids levels

Abstract Background Atrial fibrillation (AF) is associated with circulating inflammation. Short-chain fatty acids (SCFAs) derived from gut microbiota (GM) regulate leukocyte function and inhibit the release of inflammatory cytokines, which are partly mediated by the G-protein-coupled receptor 43 (GP...

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Bibliographic Details
Main Authors: Chen Fang, Kun Zuo, Zheng Liu, Li Xu, Xinchun Yang
Format: Article
Language:English
Published: BMC 2024-04-01
Series:European Journal of Medical Research
Subjects:
Atrial fibrillation
Peripheral leukocytes
GPR43
NLRP3
SCFAs
Online Access:https://doi.org/10.1186/s40001-024-01825-4

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