Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms
Background: Cancer cases are continuously increasing, while the prevalence rates of physical inactivity are also continuously increasing. Physical inactivity is a causative factor in non-communicable diseases, including cancer. However, the potential beneficial effects of exercise on cancer treatmen...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-10-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/21/5135 |
| _version_ | 1797632120016863232 |
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| author | Maria Spanoudaki Constantinos Giaginis Dimitra Karafyllaki Konstantinos Papadopoulos Evangelos Solovos Georgios Antasouras Georgios Sfikas Athanasios N. Papadopoulos Sousana K. Papadopoulou |
| author_facet | Maria Spanoudaki Constantinos Giaginis Dimitra Karafyllaki Konstantinos Papadopoulos Evangelos Solovos Georgios Antasouras Georgios Sfikas Athanasios N. Papadopoulos Sousana K. Papadopoulou |
| author_sort | Maria Spanoudaki |
| collection | DOAJ |
| description | Background: Cancer cases are continuously increasing, while the prevalence rates of physical inactivity are also continuously increasing. Physical inactivity is a causative factor in non-communicable diseases, including cancer. However, the potential beneficial effects of exercise on cancer treatment have not received much attention so far. The aim of this study was to highlight the relationship between cancer and exercise on a molecular basis. Methods: Comprehensive and in-depth research was conducted in the most accurate scientific databases by using relevant and effective keywords. Results: The mechanisms by which exercise may reduce cancer risk and/or progression may include the metabolic profile of hormones, systemic inflammation reduction, insulin sensitivity increase, antioxidant capacity augmentation, the boost to the immune system, and the direct effect on the tumor. There is currently substantial evidence that the effect of exercise may predict a stronger association with cancer and could supplementarily be embedded in cancer clinical practice to improve disease progression and prognosis. Conclusion: The field of this study requires interconnecting the overall knowledge of exercise physiology with cancer biology and cancer clinical oncology to provide the basis for personalized targeting strategies that can be merged with training as a component of a holistic co-treatment approach to optimize cancer healthcare. |
| first_indexed | 2024-03-11T11:32:23Z |
| format | Article |
| id | doaj.art-237c9e25407e4cb9ace40a5f4526c847 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-11T11:32:23Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-237c9e25407e4cb9ace40a5f4526c8472023-11-10T14:59:59ZengMDPI AGCancers2072-66942023-10-011521513510.3390/cancers15215135Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular MechanismsMaria Spanoudaki0Constantinos Giaginis1Dimitra Karafyllaki2Konstantinos Papadopoulos3Evangelos Solovos4Georgios Antasouras5Georgios Sfikas6Athanasios N. Papadopoulos7Sousana K. Papadopoulou8Department of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, GreeceDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, GreeceDepartment of Nutrition and Dietetics, School of Physical Education, Sport Science and Dietetics, University of Thessaly, 42132 Trikala, Greece424 General Military Hospital of Thessaloniki, 54621 Thessaloniki, Greece424 General Military Hospital of Thessaloniki, 54621 Thessaloniki, GreeceDepartment of Food Science and Nutrition, School of Environment, University of Aegean, 81400 Lemnos, Greece424 General Military Hospital of Thessaloniki, 54621 Thessaloniki, GreeceDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, GreeceDepartment of Nutritional Sciences and Dietetics, School of Health Sciences, International Hellenic University, 57400 Thessaloniki, GreeceBackground: Cancer cases are continuously increasing, while the prevalence rates of physical inactivity are also continuously increasing. Physical inactivity is a causative factor in non-communicable diseases, including cancer. However, the potential beneficial effects of exercise on cancer treatment have not received much attention so far. The aim of this study was to highlight the relationship between cancer and exercise on a molecular basis. Methods: Comprehensive and in-depth research was conducted in the most accurate scientific databases by using relevant and effective keywords. Results: The mechanisms by which exercise may reduce cancer risk and/or progression may include the metabolic profile of hormones, systemic inflammation reduction, insulin sensitivity increase, antioxidant capacity augmentation, the boost to the immune system, and the direct effect on the tumor. There is currently substantial evidence that the effect of exercise may predict a stronger association with cancer and could supplementarily be embedded in cancer clinical practice to improve disease progression and prognosis. Conclusion: The field of this study requires interconnecting the overall knowledge of exercise physiology with cancer biology and cancer clinical oncology to provide the basis for personalized targeting strategies that can be merged with training as a component of a holistic co-treatment approach to optimize cancer healthcare.https://www.mdpi.com/2072-6694/15/21/5135exercisecancermolecular mechanismspreventioninflammationhormones |
| spellingShingle | Maria Spanoudaki Constantinos Giaginis Dimitra Karafyllaki Konstantinos Papadopoulos Evangelos Solovos Georgios Antasouras Georgios Sfikas Athanasios N. Papadopoulos Sousana K. Papadopoulou Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms Cancers exercise cancer molecular mechanisms prevention inflammation hormones |
| title | Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms |
| title_full | Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms |
| title_fullStr | Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms |
| title_full_unstemmed | Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms |
| title_short | Exercise as a Promising Agent against Cancer: Evaluating Its Anti-Cancer Molecular Mechanisms |
| title_sort | exercise as a promising agent against cancer evaluating its anti cancer molecular mechanisms |
| topic | exercise cancer molecular mechanisms prevention inflammation hormones |
| url | https://www.mdpi.com/2072-6694/15/21/5135 |
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