Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis
Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-08-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/9/2768 |
| _version_ | 1797555441769644032 |
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| author | Shanny Sade Tamar Wainstock Eyal Sheiner Gali Pariente |
| author_facet | Shanny Sade Tamar Wainstock Eyal Sheiner Gali Pariente |
| author_sort | Shanny Sade |
| collection | DOAJ |
| description | Objective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without tuberculosis were assessed. The study groups were followed until 18 years of age tracking infectious-related morbidity and infectious-related hospitalizations and then compared. For perinatal outcome, generalized estimation equation models were used. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term infectious morbidity. A Cox proportional hazards model was conducted to control for confounders. Results: During the study period, 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries, and very low birth weight. However, offspring born to mothers with tuberculosis did not demonstrate higher rates of infectious-related morbidity. Maternal tuberculosis was not noted as an independent risk factor for long-term infectious morbidity of the offspring. Conclusion: In our study, maternal tuberculosis was found to be independently associated with adverse perinatal outcomes. However, higher risk for long-term infectious morbidity of the offspring was not demonstrated. Careful surveillance of these women is required. |
| first_indexed | 2024-03-10T16:47:31Z |
| format | Article |
| id | doaj.art-2381d561762140d48b5e487f3dd0b07b |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T16:47:31Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-2381d561762140d48b5e487f3dd0b07b2023-11-20T11:26:57ZengMDPI AGJournal of Clinical Medicine2077-03832020-08-0199276810.3390/jcm9092768Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known TuberculosisShanny Sade0Tamar Wainstock1Eyal Sheiner2Gali Pariente3Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8457108, IsraelDepartment of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8457108, IsraelDepartment of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8457108, IsraelDepartment of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer-Sheva 8457108, IsraelObjective: To evaluate the perinatal outcome of women with tuberculosis and to assess a possible association between maternal tuberculosis and long-term infectious morbidity of the offspring. Study design: Perinatal outcome and long-term infectious morbidity of offspring of mothers with and without tuberculosis were assessed. The study groups were followed until 18 years of age tracking infectious-related morbidity and infectious-related hospitalizations and then compared. For perinatal outcome, generalized estimation equation models were used. A Kaplan-Meier survival curve was used to compare cumulative incidence of long-term infectious morbidity. A Cox proportional hazards model was conducted to control for confounders. Results: During the study period, 243,682 deliveries were included, of which 46 (0.018%) occurred in women with tuberculosis. Maternal tuberculosis was found to be independently associated with placental abruption, cesarean deliveries, and very low birth weight. However, offspring born to mothers with tuberculosis did not demonstrate higher rates of infectious-related morbidity. Maternal tuberculosis was not noted as an independent risk factor for long-term infectious morbidity of the offspring. Conclusion: In our study, maternal tuberculosis was found to be independently associated with adverse perinatal outcomes. However, higher risk for long-term infectious morbidity of the offspring was not demonstrated. Careful surveillance of these women is required.https://www.mdpi.com/2077-0383/9/9/2768cesarean deliveryinfectious morbidityperinatal outcomeplacental abruptiontuberculosisvery low birth weight |
| spellingShingle | Shanny Sade Tamar Wainstock Eyal Sheiner Gali Pariente Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis Journal of Clinical Medicine cesarean delivery infectious morbidity perinatal outcome placental abruption tuberculosis very low birth weight |
| title | Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis |
| title_full | Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis |
| title_fullStr | Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis |
| title_full_unstemmed | Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis |
| title_short | Perinatal Outcome and Long-Term Infectious Morbidity of Offspring Born to Women with Known Tuberculosis |
| title_sort | perinatal outcome and long term infectious morbidity of offspring born to women with known tuberculosis |
| topic | cesarean delivery infectious morbidity perinatal outcome placental abruption tuberculosis very low birth weight |
| url | https://www.mdpi.com/2077-0383/9/9/2768 |
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