Electroacupuncture intervention of visceral hypersensitivity is involved in PAR-2-activation and CGRP-release in the spinal cord

Electroacupuncture intervention of visceral hypersensitivity is involved in PAR-2-activation and CGRP-release in the spinal cord

Abstract Electroacupuncture (EA) relieves visceral hypersensitivity (VH) with underlying inflammatory bowel diseases. However, the mechanism by which EA treats ileitis-induced VH is not clearly known. To assess the effects of EA on ileitis-induced VH and confirm whether EA attenuates VH through spin...

Full description

Bibliographic Details
Main Authors:	Manoj K. Shah, Yi Ding, Juan Wan, Habibullah Janyaro, Adnan Hassan Tahir, Vitaly Vodyanoy, Ming-Xing Ding
Format:	Article
Language:	English
Published:	Nature Portfolio 2020-07-01
Series:	Scientific Reports
Online Access:	https://doi.org/10.1038/s41598-020-67702-2

Similar Items

Electroacupuncture Attenuates Visceral Hypersensitivity by Inhibiting JAK2/STAT3 Signaling Pathway in the Descending Pain Modulation System
by: Juan Wan, et al.
Published: (2017-11-01)

Visceral hypersensitivity is provoked by 2,4,6-trinitrobenzene sulfonic acid-induced ileitis in rats
by: Manoj Kumar Shah, et al.
Published: (2016-07-01)

Electroacupuncture Relieves Visceral Hypersensitivity via Balancing PAR2 and PAR4 in the Descending Pain Modulatory System of Goats
by: Panpan Guo, et al.
Published: (2023-06-01)

Peripheral and Spinal Mechanisms Involved in Electro-Acupuncture Therapy for Visceral Hypersensitivity
by: Adnan Hassan Tahir, et al.
Published: (2021-09-01)

Visceral pain triggered by traction on the ileocecal ligament with ileitis
by: Janyaro H, et al.
Published: (2016-09-01)

CGRP accelerates the pathogenesis of neurological heterotopic ossification following spinal cord injury
by: Xiguang Sang, et al.
Published: (2019-12-01)

Hypersensitivity Induced by Activation of Spinal Cord PAR2 Receptors Is Partially Mediated by TRPV1 Receptors.
by: Petra Mrozkova, et al.
Published: (2016-01-01)

Electroacupuncture for Spinal Cord Injury: A Scientific Study of Traditional Medicine
by: Liquan Wu
Published: (2022-09-01)

Small-Conductance Ca2+-Activated K+ Channel 2 in the Dorsal Horn of Spinal Cord Participates in Visceral Hypersensitivity in Rats
by: Yu Song, et al.
Published: (2018-08-01)

Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity
by: Chen Y, et al.
Published: (2021-02-01)

Electroacupuncture Attenuates Post-Inflammatory IBS-Associated Visceral and Somatic Hypersensitivity and Correlates With the Regulatory Mechanism of Epac1–Piezo2 Axis
by: Jing Guo, et al.
Published: (2022-07-01)

Comprehensive phenotyping of cutaneous afferents reveals early-onset alterations in nociceptor response properties, release of CGRP, and hindpaw edema following spinal cord injury
by: Olivia C. Eller, et al.
Published: (2022-08-01)

Transcription Profiling of a Revealed the Potential Molecular Mechanism of Governor Vessel Electroacupuncture for Spinal Cord Injury in Rats
by: Xingru Xiao, et al.
Published: (2022-09-01)

Electroacupuncture at ST36 Relieves Visceral Hypersensitivity via the NGF/TrkA/TRPV1 Peripheral Afferent Pathway in a Rodent Model of Post-Inflammation Rectal Hypersensitivity [Erratum]
by: Chen Y, et al.
Published: (2021-02-01)

Electroacupuncture promotes the recovery of motor neuron function in the anterior horn of the injured spinal cord
by: Jian-hui Yang, et al.
Published: (2015-01-01)

Electroacupuncture modulates the intestinal microecology to improve intestinal motility in spinal cord injury rats
by: Jie Cheng, et al.
Published: (2022-03-01)

CGRP Administration Into the Cerebellum Evokes Light Aversion, Tactile Hypersensitivity, and Nociceptive Squint in Mice
by: Mengya Wang, et al.
Published: (2022-04-01)

Electroacupuncture Facilitates the Integration of Neural Stem Cell-Derived Neural Network with Transected Rat Spinal Cord
by: Hui Jin, et al.
Published: (2019-02-01)

Spinal PAR2 Activation Contributes to Hypersensitivity Induced by Peripheral Inflammation in Rats
by: Petra Mrozkova, et al.
Published: (2021-01-01)

Spinal cord anesthesia with meperidine in a patient with hypersensitivity to local anesthesia
by: Alexis Ramón Pineda González
Published: (2019-08-01)

The Anti-CGRP Antibody Fremanezumab Lowers CGRP Release from Rat Dura Mater and Meningeal Blood Flow
by: Mária Dux, et al.
Published: (2022-05-01)

Effects of electroacupuncture combined with hydrogel on the formation and changes in the glial scar in rats with spinal cord injury
by: Kaitan Yang, et al.
Published: (2022-04-01)

Combined-Acupoint Electroacupuncture Induces Better Analgesia via Activating the Endocannabinoid System in the Spinal Cord
by: Zhenhua Jiang, et al.
Published: (2022-01-01)

Electroacupuncture Inhibits NLRP3 Activation by Regulating CMPK2 After Spinal Cord Injury
by: Yi Chen, et al.
Published: (2022-03-01)

Calcitonin gene-related peptide (CGRP) and its receptor components in human and rat spinal trigeminal nucleus and spinal cord at C1-level
by: Eftekhari Sajedeh, et al.
Published: (2011-11-01)

Effect of electroacupuncture on the mRNA and protein expression of Rho-A and Rho-associated kinase II in spinal cord injury rats
by: You-jiang Min, et al.
Published: (2017-01-01)

Mesenchymal Stem Cells Combined With Electroacupuncture Treatment Regulate the Subpopulation of Macrophages and Astrocytes to Facilitate Axonal Regeneration in Transected Spinal Cord
by: Rongyi Zhang, et al.
Published: (2023-12-01)

Effects of general anesthetics on visceral pain transmission in the spinal cord
by: Yue Yun, et al.
Published: (2008-10-01)

Electroacupuncture Promoting Axonal Regeneration in Spinal Cord Injury Rats via Suppression of Nogo/NgR and Rho/ROCK Signaling Pathway
by: Xiao WP, et al.
Published: (2019-12-01)

Antinociceptive effects of dexmedetomidine via spinal substance P and CGRP
by: Li Ruiqin, et al.
Published: (2015-01-01)

Current Aspects Regarding the Clinical Relevance of Electroacupuncture in Dogs with Spinal Cord Injury: A Literature Review
by: Madalina Florina Dragomir, et al.
Published: (2021-01-01)

Case report: Ultrasound-guided multi-site electroacupuncture stimulation for a patient with spinal cord injury
by: Xi-Zi Song, et al.
Published: (2022-08-01)

Neuregulin1-ErbB4 Signaling in Spinal Cord Participates in Electroacupuncture Analgesia in Inflammatory Pain
by: Chaofan Wan, et al.
Published: (2021-01-01)

Electroacupuncture improves microcirculation and neuronal morphology in the spinal cord of a rat model of intervertebral disc extrusion
by: Dai-xun Jiang, et al.
Published: (2015-01-01)

Bone Marrow Mesenchymal Stem Cells and Electroacupuncture Downregulate the Inhibitor Molecules and Promote the Axonal Regeneration in the Transected Spinal Cord of Rats
by: Ying Ding, et al.
Published: (2011-05-01)

Neonatal Colonic Inflammation Increases Spinal Transmission and Cystathionine β-Synthetase Expression in Spinal Dorsal Horn of Rats with Visceral Hypersensitivity
by: Liting Zhao, et al.
Published: (2017-10-01)

Effects and mechanisms of auricular electroacupuncture on gastric hypersensitivity in a rodent model of functional dyspepsia.
by: Jingzhu Zhou, et al.
Published: (2017-01-01)

Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production
by: Julien Pujo, et al.
Published: (2023-12-01)

Inhibition of chemokine CX3CL1 in spinal cord mediates the electroacupuncture-induced suppression of inflammatory pain
by: Li Y, et al.
Published: (2019-09-01)

Electroacupuncture in the repair of spinal cord injury: inhibiting the Notch signaling pathway and promoting neural stem cell proliferation
by: Xin Geng, et al.
Published: (2015-01-01)